(Press-News.org) A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 21, entitled, “1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5’-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway.”
5’-Adenosine monophosphate-activated protein kinase (AMPK) is a metabolic sensor that serves as a cellular housekeeper; it also controls energy homeostasis and stress resistance. Thus, correct regulation of this factor can enhance health and survival. AMPK signaling may have a critical role in aging-associated brain diseases. Some in vitro studies have shown that 1,5-anhydro-D-fructose (1,5-AF) induces AMPK activation.
In this new study, researchers Kiyoshi Kikuchi, Shotaro Otsuka, Seiya Takada, Kazuki Nakanishi, Kentaro Setoyama, Harutoshi Sakakima, Eiichiro Tanaka, and Ikuro Maruyama from Kagoshima University investigated the effects of 1,5-AF on the AMPK/PGC-1α/BDNF pathway in multiple animal models of human aging-associated brain diseases.
“In the present study, we experimentally evaluated the effects of 1,5-AF on aging-associated brain diseases in vivo using an animal model of acute ischemic stroke (AIS), stroke-prone spontaneously hypertensive rats (SHRSPs), and the spontaneous senescence-accelerated mouse-prone 8 (SAMP8) model.”
In the AIS model, intraperitoneal injection of 1,5-AF reduced cerebral infarct volume, neurological deficits, and mortality. In SHRSPs, oral administration of 1,5-AF reduced blood pressure and prolonged survival. In the SAMP8 model, oral administration of 1,5-AF alleviated aging-related decline in motor cognitive function. Although aging reduced the expression levels of peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) and brain-derived neurotrophic factor (BDNF), the researchers found that 1,5-AF activated AMPK, which led to upregulation of the PGC-1α/BDNF pathway.
“Our results suggest that 1,5-AF can induce endogenous neurovascular protection, potentially preventing aging-associated brain diseases. Clinical studies are needed to determine whether 1,5-AF can prevent aging-associated brain diseases.”
Read the full study: DOI: https://doi.org/10.18632/aging.205228
Corresponding Authors: Kiyoshi Kikuchi, Ikuro Maruyama
Corresponding Emails: kikuchi_kiyoshi@kurume-u.ac.jp, maruyama-i@eva.hi-ho.ne.jp
Keywords: AMP-activated protein kinases, brain-derived neurotrophic factor, peroxisome proliferator-activated receptors, blood pressure, aging
Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.https://doi.org/10.18632/aging.205228
About Aging:
Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.
Please visit our website at www.Aging-US.com and connect with us:
SoundCloud
Facebook
X, formerly known as Twitter
Instagram
YouTube
LabTube
LinkedIn
Reddit
Pinterest
Click here to subscribe to Aging publication updates.
For media inquiries, please contact media@impactjournals.com.
Aging (Aging-US) Journal Office
6666 E. Quaker Str., Suite 1B
Orchard Park, NY 14127
Phone: 1-800-922-0957, option 1
###
END
“The Achilles’ heel of CRISPR application is the delivery of sgRNA/Cas9 to the desired tissues.”
BUFFALO, NY- November 28, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on November 27, 2023, entitled, “The double-edge sword of CRISPR application for in vivo studies.”
In this new paper, researcher Martin K. Thomsen from Aarhus University begins his editorial by discussing a hallmark paper that was published a decade ago by Platt et al. on the in vivo ...
Our ability to pay attention to tasks—a key component of our everyday lives—is heavily influenced by factors like motivation, arousal and alertness. Maintaining focus can be especially challenging when the task is boring or repetitive.
“In many activities, it is difficult to maintain a high level of focus over time. Our research asks why this is the case,” said Matthew K. Robison, assistant professor of psychology at The University of Texas at Arlington.
He and colleagues at the University ...
Katherine Rich, MD MPH, resident in the MGH Department of Medicine, is the first author of a recently published paper in JAMA Network Open, “Projected Life Expectancy Gains from Improvements in HIV Care in Black and White Men Who Have Sex With Men.” Aima Ahonkhai, MD MPH and Emily Hyle, MD MSc, physician investigators in the Division of Infectious Diseases at Massachusetts General Hospital, are co-senior authors.
What Question Were You Investigating?
Substantial inequities persist across the HIV care continuum in the US; Black people with HIV bear a disproportionate disease burden due, ...
MIAMI, FLORIDA (Nov. 28, 2023) – Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have found that country of birth – not just geographic region – is a key risk factor for gastric intestinal metaplasia, a precursor lesion of stomach cancer.
Although stomach cancer, often called gastric cancer, is relatively rare in the United States, it is much more common and deadly among Hispanics, non-Hispanic Black people, Asian Americans and Pacific Islanders than among the white population.
Sylvester and the University of Miami Health System serve a widely diverse racial and ethnic population, including ...
Virtual, augmented and other extended reality technologies present the possibility to transform health care, education, entertainment, communication and more.
And that transformation is close.
Headsets and haptic gloves could connect doctors and patients thousands of miles apart in a virtual hospital. Sensors could monitor someone's health or help teachers know if their students are paying attention. Scanners could allow objects from a person's home to appear in their favorite video game. Glasses could help people with visual impairments navigate the world around them. Extended ...
A five-year, $2 million grant to study the pharmacological effects of the areca nut, commonly known as the betel nut, was awarded to a UTHealth Houston researcher by the National Institute on Drug Abuse, part of the National Institutes of Health (NIH).
The study, led by Alan Myers, PharmD, PhD, associate professor of pharmacology with UTHealth Houston School of Dentistry, will investigate how chemicals in the areca nut are metabolized in the body’s organs, particularly in the liver, and how that process is disrupted by alcohol or menthol.
“On the global level, areca nut chewing has been around since antiquity, but still poses a major public health ...
Optimal windows exist for action and perception during the 0.8 seconds of a heartbeat, according to research published November 28th in the open access journal PLOS Biology. The sequence of contraction and relaxation is linked to changes in the motor system and its ability to respond to stimulation, and this could have implications for treatments for depression and stroke that excite nerve cells.
The ways in which we perceive and engage with the world are influenced by internal bodily processes such as heartbeats, respiration and digestion. Cardiac activity can influence auditory and ...
A new catalog produced by a French-led international team of astronomers shows that NASA’s Fermi Gamma-ray Space Telescope has discovered 294 gamma-ray-emitting pulsars, while another 34 suspects await confirmation. This is 27 times the number known before the mission launched in 2008.
“Pulsars touch on a wide range of astrophysics research, from cosmic rays and stellar evolution to the search for gravitational waves and dark matter,” said study coordinator David Smith, research director at the Bordeaux Astrophysics Laboratory in Gironde, France, which is part of CNRS (the ...
FINDINGS
Researchers at the UCLA Jonsson Comprehensive Cancer Center have found certain immune cells can still fight cancer even when the cancer cells lack an important protein that the immune system relies on to help track down cancer cells.
The team discovered the absence of the crucial protein B2M seems to activate an alternative immune response involving natural killer (NK) cells and CD4+ T cells in both animal studies and patient tumor biopsies, indicating a potential backup mechanism in the immune system to recognize and attack cancer cells.
BACKGROUND
Immunotherapies, such as immune ...
Providence, R.I. – From the ability to conduct clinical visits online to utilizing artificial intelligence to effectively diagnose patients, technology has changed how all doctors practice medicine. One published paper in the November/December issue of Annals of Family Medicine explains how AI-driven technology presents new opportunities for more effective patient care while a second paper describes the interplay between fulfillment of basic psychological needs at work and technology use in maintaining clinician well-being.
In ...
