(Press-News.org) Cannabis use for medicinal or recreational purposes is now permitted is most states in the U.S. Many of the products sold in dispensaries contain delta-9-tetrahydrocannabinol (better known as “THC”), and are thus classified as Schedule I drugs, making them illegal under federal law.
However, there is a parallel market for products derived from hemp—defined as cannabis containing less that 0.3 percent THC—spurred in part by the passage of the 2018 Farm Bill, which removed hemp-derived cannabinoids from the federal Controlled Substances Act.
A new U-M study published in JAMA Network Open examines past-year use of some of these hemp-derived cannabinoids, including cannabidiol (CBD), Delta 8-THC, cannabigerol (CBG), and cannabinol (CBN).
“While the de-scheduling of hemp products initially opened up the market for CBD products, it also applies to the 100-plus cannabinoids also found in the plant. That means, as with CBD, all of them can follow that same path and be sold in gas stations, as ingredients in cosmetics, as well as in dispensaries—there will likely be substantial proliferation of some of these compounds,” said Kevin Boehnke, Ph.D. of the Chronic Pain and Fatigue Research Center and the Department of Anesthesiology at the University of Michigan Medical School.
Using a census-representative sample of adults from the National Opinion Research Center (NORC) AmeriSpeak panel, Boehnke and his colleagues examined knowledge of and past-year use of the most popular hemp derived cannabinoids.
Overall, 72% participants heard of CBD, while fewer had heard of delta-8-THC (41%), CBG (18%), or CBN (17%). Similarly, 21% reported using CBD in the past year, compared with 12% for delta-8-THC, 5% for CBG, and 4% for CBN. Furthermore, people living in states without legal medical or recreational cannabis laws had higher rates of using delta-8-THC.
“Delta-8-THC purportedly has quite similar effects to delta-9-THC (better known as THC). In other words, there is a loophole where people in states without legal cannabis can get high legally on delta-8-THC. It makes sense then that people who don’t have access to regulated markets would be more likely to use it,” said Boehnke.
However, use of these alternative cannabinoids is concerning, says Boehnke, because these products are largely unregulated and have inadequate safety testing for contaminants like pesticides and solvents. Further, many may not contain the amounts listed on the label.
“Not only are people with medical conditions being sold products with uncertain therapeutic effects, but these products may contain contaminants that are harmful,” said Boehnke. He adds that without a basic framework ensuring adequate laboratory testing for safety, alternative cannabinoid products could be putting people, especially young people, at risk.
Additional authors include Adrianne R. Wilson-Poe PhD, Tristin Smith MPH, Michael R. Elliott PhD, and Daniel J. Kruger PhD.
Paper cited: “Past-year use prevalence of cannabinoids CBD, CBG, CBN, and delta-8-THC in the United States,” JAMA Network Open, http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.47373?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121323
END
Growing use of hemp-derived alternative cannabis products containing CBD, Delta-8-THC, CBG, CBN
A lack of regulation around CBD, Delta-8 and other cannabinoids could open up consumers for harm
2023-12-13
ELSE PRESS RELEASES FROM THIS DATE:
Penn Medicine research shows how stress activates neurons that disrupt sleep
2023-12-13
PHILADELPHIA— New research reveals that neurons in the preoptic hypothalamus—the region of the brain that regulates sleep and body temperature—are rhythmically activated during non-rapid eye movement sleep (NREM). Stress activates these brain cells out of turn, causing “microarousals,” that interrupt sleep cycles and decrease the duration of sleep episodes, according to research from Perelman School of Medicine at the University of Pennsylvania, published today in Current Biology.
While our bodies are at rest when we are asleep, ...
New study sheds light on how the brain learns to seek reward
2023-12-13
By Jake Siegel
Imagine you’re teaching a dog to play fetch. You throw a ball, and your dog sprints after it, picks it up, and runs back. You then reward your panting pup with a treat. But now comes the real trick for your dog: figuring out which part of that sequence earned the treat. Scientists call this the 'credit assignment problem' in the brain. It's a fundamental question about understanding which actions are responsible for the positive outcomes we experience.
Dopamine, a key chemical ...
Salk teams assemble first full epigenomic cell atlas of the mouse brain
2023-12-13
LA JOLLA (December 14, 2023)—Salk Institute researchers, as part of a worldwide initiative to revolutionize scientists’ understanding of the brain, analyzed more than 2 million brain cells from mice to assemble the most complete atlas ever of the mouse brain. Their work, published December 14, 2023 in a special issue of Nature, not only details the thousands of cell types present in the brain but also how those cells connect and the genes and regulatory programs that are active in each cell.
The efforts were coordinated by the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies® Initiative, or the BRAIN Initiative®, ...
Scientists unveil first complete cellular map of adult mouse brain
2023-12-13
By Jake Siegel
Six years and 32 million cells later, scientists have created the first full cellular map of a mammalian brain. In a set of 10 papers in Nature today, a network of researchers unveiled an atlas cataloging the location and type of every cell in the adult mouse brain. Using advanced technologies that profile individual cells, the teams identified over 5,300 cell types – far more than known before – and pinpointed their locations within the brain’s intricate geography. ...
Using next-gen CRISPR tool, Gladstone scientists create unprecedented molecular map of human immune response
2023-12-13
SAN FRANCISCO—December 13, 2023—In a study of historic scale, scientists at Gladstone Institutes have created an intricate map of how the immune system functions, examining the detailed molecular structures governing human T cells using the next-generation CRISPR tool known as base editing.
Their findings, published in Nature, uncover detailed information that could help overcome the limitations of today’s immunotherapies and identify new drug targets for a wide range of diseases, including autoimmune diseases and cancer.
Led by Gladstone Senior Investigator Alex Marson, MD, PhD, the team dove deep into the DNA of T cells, pinpointing ...
Discovery of magnetic liquid crystal
2023-12-13
Liquid crystal is a state of matter that exhibits properties of both liquid and solid. It can flow like a liquid, while its constituent molecules are aligned as in a solid. The liquid crystal is widely used nowadays, for example, as a core element of LCD devices. The magnetic analog of this kind of material is dubbed the “spin-nematic phase”, where spin moments play the role of the molecules. However, it has not yet been directly observed despite its prediction a half-century ago. The main challenge stems ...
A rare enzyme role change with bacterial defense system assembly
2023-12-13
COLUMBUS, Ohio – Scientists have revealed a never-before-seen phenomenon in a protein: Alone, the enzyme processes DNA and RNA but, when bound to another protein as part of a defense system, interacts with a completely different type of compound to help bacteria commit suicide.
The finding came about as the researchers focused on detailing how this defense mechanism works in bacteria that are infected by phages, viruses that invade and make copies of themselves inside bacterial cells. In addition to detailing the proteins’ structures and binding sites, the experiments unearthed ...
Machine learning sees into the future to prevent sight loss in humans
2023-12-13
Researchers from Tokyo Medical and Dental University (TMDU) develop models based on machine learning that predict long-term visual acuity in patients with high myopia, one of the top three causes of irreversible blindness in many regions of the world
Tokyo, Japan – Machine learning has been found to predict well the outcomes of many health conditions. Now, researchers from Japan have found a way to predict whether people with severe shortsightedness will have good or bad vision in the future.
In a study recently published in ...
Scientists unveil complete cell map of a whole mammalian brain
2023-12-13
For the first time ever, an international team of researchers has created a complete cell atlas of a whole mammalian brain. This atlas serves as a map for the mouse brain, describing the type, location, and molecular information of more than 32 million cells and providing information on connectivity between these cells. The mouse is the most commonly used vertebrate experimental model in neuroscience research, and this cellular map paves the way for a greater understanding of the human brain—arguably the most powerful computer in the world. The cell atlas also lays the foundation for the development of a new generation of precision therapeutics for people ...
Cholesterol-lowering therapy may hinder aggressive type of colorectal tumor
2023-12-13
Hard-to-detect colorectal pre-cancerous lesions known as serrated polyps, and the aggressive tumors that develop from them, depend heavily on the ramped-up production of cholesterol, according to a preclinical study from researchers at Weill Cornell Medicine. The finding points to the possibility of using cholesterol-lowering drugs to prevent or treat such tumors.
In the study, published Oct. 13 in Nature Communications, the researchers analyzed mice that develop serrated polyps and tumors, detailing the chain of molecular events in these tissues that leads to increased cholesterol production.
They ...
LAST 30 PRESS RELEASES:
Youngest in class at higher risk of mental health problems
American Heart Association announces new volunteer leaders for 2025-26
Gut microbiota analysis can help catch gestational diabetes
FAU’s Paulina DeVito awarded prestigious NSF Graduate Research Fellowship
Champions for change – Paid time off initiative just made clinical trials participation easier
Fentanyl detection through packaging
Prof. Eran Meshorer elected to EMBO for pioneering work in epigenetics
New 3D glacier visualizations provide insights into a hotter Earth
Creativity across disciplines
Consequences of low Antarctic sea ice
Hear here: How loudness and acoustic cues help us judge where a speaker is facing
A unique method of rare-earth recycling can strengthen the raw material independence of Europe and America
Epilepsy self-management program shows promise to control seizures, improve mood and quality of life
Fat may play an important role in brain metabolism
New study finds no lasting impact of pandemic pet ownership on human well-being
New insights on genetic damage of some chemotherapies could guide future treatments with less harmful side effects
Gut microbes could protect us from toxic ‘forever chemicals’
Novel modelling links sea ice loss to Antarctic ice shelf calving events
Scientists can tell how fast you're aging from a single brain scan
U.S. uterine cancer incidence and mortality rates expected to significantly increase by 2050
Public take the lead in discovery of new exploding star
What are they vaping? Study reveals alarming surge in adolescent vaping of THC, CBD, and synthetic cannabinoids
ECMWF - delivering forecasts over 10 times faster and cutting energy usage by 1000
Brazilian neuroscientist reveals how viral infections transform the brain through microscopic detective work
Turning social fragmentation into action through discovering relatedness
Cheese may really be giving you nightmares, scientists find
Study reveals most common medical emergencies in schools
Breathable yet protective: Next-gen medical textiles with micro/nano networks
Frequency-engineered MXene supercapacitors enable efficient pulse charging in TENG–SC hybrid systems
Developed an AI-based classification system for facial pigmented lesions
[Press-News.org] Growing use of hemp-derived alternative cannabis products containing CBD, Delta-8-THC, CBG, CBNA lack of regulation around CBD, Delta-8 and other cannabinoids could open up consumers for harm