(Press-News.org)
A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, “Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema.”
Smoking is the main risk factor for many lung diseases including chronic obstructive pulmonary disease. Cigarette smoke (CS) contains carcinogenic and reactive oxygen species that favor DNA mutations and perturb the homeostasis and environment of cells. CS induces lung cell senescence resulting in a stable proliferation arrest and a senescence-associated secretory phenotype. It was recently reported that senescent cell accumulation promotes several lung diseases.
In this new study, researchers Alberta Palazzo, Gabriela Makulyte, Delphine Goerhig, Jean-Jacques Médard, Vincent Gros, François Trottein, Serge Adnot, David Vindrieux, Jean-Michel Flaman, and David Bernard from Université de Lyon, Equipe Labellisée la Ligue Contre le Cancer, Université Paris Est Créteil, Hôpital Henri Mondor, and Université Lille performed a chemical screen, using an FDA-approved drug library, to identify compounds selectively promoting the death of CS-induced senescent lung cells.
“Here, our aim was to identify senolytic compounds in the context of CS-induced senescence and to assess whether they improved lung emphysema.”
Aside from the well-known senolytic, ABT-263, the researchers identified other potentially new senescence-eliminating compounds, including a new class of molecules, the dihydropyridine family of calcium voltage-gated channel (CaV) blockers. Among these blockers, Benidipine decreased senescent lung cells and ameliorates lung emphysema in a mouse model. The dihydropyridine family of CaV blockers thus constitutes a new class of senolytics that could improve lung diseases.
“Hence, our work paves the way for further studies on the senolytic activity of CaV blockers in different senescence contexts and age-related diseases.”
Read the full paper: DOI: https://doi.org/10.18632/aging.205259
Corresponding Author: David Bernard
Corresponding Email: david.bernard@lyon.unicancer.fr
Keywords: senolytic, cigarette smoke, lung disease, cellular senescence, calcium channel
Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.https://doi.org/10.18632/aging.205259
About Aging:
Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.
Please visit our website at www.Aging-US.com and connect with us:
SoundCloud
Facebook
X, formerly known as Twitter
Instagram
YouTube
LabTube
LinkedIn
Reddit
Pinterest
Click here to subscribe to Aging publication updates.
For media inquiries, please contact media@impactjournals.com.
Aging (Aging-US) Journal Office
6666 E. Quaker Str., Suite 1B
Orchard Park, NY 14127
Phone: 1-800-922-0957, option 1
###
END
Despite their promise, immunotherapies fail to treat many cancers, including over 80% of some of the most advanced breast cancers. And many of those patients who do respond still experience metastases eventually. New research from Stanford University and the Arc Institute has revealed a better way to predict and improve patient responses.
A team led by Lingyin Li, associate professor of biochemistry at Stanford and Arc Core Investigator, found that a protein called ENPP1 acts as an on/off switch that controls breast cancer’s ability to both resist immunotherapy and metastasize. The study, published on ...
Oak Ridge National Laboratory researchers have identified the most energy-efficient 2024 model year vehicles available in the United States, including electric and hybrids, in the latest edition of the Department of Energy’s Fuel Economy Guide.
The annual online resource compares fuel costs for two-seaters up to large sedans, small and midsize station wagons, minivans, small and standard sport utility vehicles and small and standard pickup trucks. A quick reference top 10 list is searchable for make, model and class, too.
“With the national average of gasoline over $3 per gallon, drivers need to know how much they can save by ...
EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, DECEMBER 20, 2023
MINNEAPOLIS – Signs of injury to the brain’s white matter called white matter hyperintensities, as seen on brain scans, may be tied more strongly to vascular risk factors, brain shrinkage, and other markers of dementia in former tackle football players than in those who did not play football, according to a study published in the December 20, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
“Studies have shown that athletes exposed to repetitive head impacts can have increased white matter hyperintensity burden in their brains,” ...
BINGHAMTON, N.Y. -- A Binghamton University team is one of just 18 nationally that will share in $100 million in U.S. National Science Foundation (NSF) funding from the Technology, Innovation and Partnerships (TIP) Directorate to accelerate the pace and scale of translational research.
The Accelerating Research Translation (ART) program will provide $6 million to Binghamton as a cooperative agreement over four years to source and grow pivotal innovations that, with help from the technology transfer office, can go to market and have a positive impact on society.
“Binghamton is quickly ...
When did archery arise in the Americas? And what were the effects of this technology on society?
These questions have long been debated among anthropologists and archaeologists. But a study led by a University of California, Davis, anthropologist, is shining light on this mystery.
Focusing on the Lake Titicaca Basin in the Andes mountains, anthropologists found through analysis of 1,179 projectile points that the rise of archery technology dates to around 5,000 years ago. Previous research held that archery in the Andes emerged around 3,000 years ago.
The new research indicates that the adoption of bow-and-arrow technology coincided with both the expansion of ...
Ochsner Health Network, LLC (OHN), the Gulf South’s largest physician-led clinically integrated network, is pleased to report its 2022 – 2023 impact resulting from care delivered to nearly a half-million patients living throughout the Gulf South. The network’s all-new digital report boasts more than $56 million in total cost-of-care savings to our community’s most vulnerable populations, with $38 million in rewards to be shared among the network’s providers.
“Our country’s healthcare system must evolve; our communities’ health must improve; and the rising costs of care must be reversed. Proudly, Ochsner Health Network remains ...
A new review paper was published in Oncotarget's Volume 14 on December 12, 2023, entitled, “Current perspectives on the management of refractory or relapsed classic hodgkin lymphoma in Brazil: Balancing efficacy, safety, and tolerability.”
Classic Hodgkin lymphoma (CHL), which accounts for 90–95% of all cases of Hodgkin lymphoma, is the most frequent cancer in adolescents and the most frequent lymphoma in adolescents and young adults. Despite progressive improvements over past decades and the general sensitivity of ...
Young adults who are more familiar with e-cigarette marketing practices are more likely to have attitudes against vaping than those unaware of the industry’s marketing, according to a study led by Drexel University public health researchers published this month in the BMJ journal Tobacco Control. Expanding on ways cigarettes were marketed in the 1970s, such as using models and hosting smoking events, e-cigarette marketing includes more modern tactics, like paying social media influencers to promote vaping. The findings, from researchers at Drexel’s Dornsife School of Public Health and The National Institute ...
A surprising MIT study published in Nature at the end of 2016 helped to spur interest in the possibility that light flickering at the frequency of a particular gamma-band brain rhythm could produce meaningful therapeutic effects for people with Alzheimer’s disease. In a new review paper in the Journal of Internal Medicine, the lab that led those studies takes stock of what a growing number of scientists worldwide have been finding out since then in dozens of clinical and lab benchtop studies.
Brain rhythms (also called brain “waves” or ...
In a new study, viewers of Facebook users’ posts came away with perceptions of the users that differed from the users’ own self-perceptions. Qi Wang and colleagues at Cornell University, New York, US, present these findings in the open-access journal PLOS ONE on December 20, 2023.
Many people post on social media platforms in order to express themselves and connect with others. Prior research has shown that viewers of personal websites, such as blogs or online profiles, form largely accurate perceptions ...
