PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Despite use of tecovirimat since the beginning of the 2022 mpox outbreak, few data have been published on its antiviral effect in humans

This study predicts the impact of early tecovirimat administration on the time to viral clearance in patients with mpox infection, using an integrative modeling approach combining pre-clinical and clinical data

Despite use of tecovirimat since the beginning of the 2022 mpox outbreak, few data have been published on its antiviral effect in humans
2023-12-21
(Press-News.org)

Despite use of tecovirimat since the beginning of the 2022 mpox outbreak, few data have been published on its antiviral effect in humans; this study predicts the impact of early tecovirimat administration on the time to viral clearance in patients with mpox infection, using an integrative modeling approach combining pre-clinical and clinical data

#####

In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology:   http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002249

Article Title: Early administration of tecovirimat shortens the time to mpox clearance in a model of human infection

Author Countries: France, Spain, United Kingdom, United States, Papua New Ginea

Funding: BTN received funding from IAME UMR 137, Université Paris Cité, INSERM, F-75018, Paris, France (https://www.iame-research.center/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

END


[Attachments] See images for this press release:
Despite use of tecovirimat since the beginning of the 2022 mpox outbreak, few data have been published on its antiviral effect in humans

ELSE PRESS RELEASES FROM THIS DATE:

How technology and economics can help save endangered species

2023-12-21
COLUMBUS, Ohio – A lot has changed in the world since the Endangered Species Act (ESA) was enacted 50 years ago in December 1973.   Two researchers at The Ohio State University were among a group of experts invited by the journal Science to discuss how the ESA has evolved and what its future might hold.   Tanya Berger-Wolf, faculty director of Ohio State’s Translational Data Analytics Institute, led a group that wrote on “Sustainable, trustworthy, human-technology partnership.”  Amy Ando, professor and chair of the university’s Department of Agricultural, Environmental, and Development Economics, ...

Sniffing women’s tears reduces aggressive behavior in men

Sniffing women’s tears reduces aggressive behavior in men
2023-12-21
New research, publishing December 21st in the open access journal in PLOS Biology, shows that tears from women contain chemicals that block aggression in men. The study led by Shani Agron at the Weizmann Institute of Science, Israel, finds that sniffing tears leads to reduced brain activity related to aggression, which results is less aggressive behavior. Male aggression in rodents is known to be blocked when they smell female tears. This is an example of social chemosignaling, a process that is common in animals but less common—or less understood—in humans. To determine whether tears have the same affect in people, ...

Polar bear fur-inspired fibers offer exceptional thermal insulation, tested in a sweater

2023-12-21
Inspired by the structure of polar bear fur, researchers present a knittable aerogel fiber with exceptional thermal and mechanical properties. The fibers are washable, dyeable, durable, and well-suited to be used in advanced textiles. This allowed the researchers to test them in a sweater that demonstrated impressive thermal insulation, among other features. Aerogels are an ideal material for thermal insulation. They demonstrate high porosity and extremely low thermal conductivity. However, the application of ...

Racial disparities in health motivate more support for social action than other racial disparities

2023-12-21
Racial disparities related to health and physical well-being motivate Americans to take action for social change more than racial disparities related to other factors, like economics, a new study finds. This is because health-related racial inequalities are perceived to be more unjust. The results suggest that framing racial disparities to tap into feelings of moral injustice may motivate policy reform – a finding of potential interest to policymakers, social movements, and citizens seeking to gain support for actions to reduce racial inequality. “…this work can help us understand ...

Octopus DNA reveals West Antarctic Ice Sheet collapse during Last Interglacial

2023-12-21
Genetic analyses of an Antarctic octopus show that the West Antarctic Ice Sheet (WAIS) collapsed during the Last Interglacial ~129,000 to 116,000 years ago when temperatures were only about 1 degree Celsius (°C) warmer than preindustrial levels. The findings suggest that WAIS collapse and resultant sea-level rise could be caused by even the minimal temperature rises projected by the most optimistic climate change mitigation plans. Climate change is driving unprecedented change to Earth’s cryosphere. The West Antarctic Ice Sheet is considered particularly vulnerable to warming ...

Can cryptocurrencies be legal tender? A case study from El Salvador

2023-12-21
In El Salvador, preference for cash and privacy fears deterred the widespread adoption of Bitcoin as an everyday currency, researchers report. The findings suggest that policies incentivizing cryptocurrency adoption as legal tender will likely fail unless populations are financially literate and already trust digital currencies. The introduction of digital currencies is one of the most important developments in monetary economics in the last decade. Unlike traditional digital currencies, which rely on central authorities such as governments or banks governed by regulations ...

Researchers map how measles virus spreads in human brain

2023-12-21
ROCHESTER, Minn. — Mayo Clinic researchers mapped how the measles virus mutated and spread in the brain of a person who succumbed to a rare, lethal brain disease. New cases of this disease, which is a complication of the measles virus, may occur as measles reemerges among the unvaccinated, say researchers. Using the latest tools in genetic sequencing, researchers at Mayo Clinic reconstructed how a collective of viral genomes colonized a human brain. The virus acquired distinct mutations that drove the spread of the virus from the frontal cortex outward. "Our study provides compelling data that ...

Organic compounds in asteroids formed in colder regions of space: study

2023-12-21
Analysis of organic compounds – called polycyclic aromatic hydrocarbons (PAHs) – extracted from the Ryugu asteroid and Murchison meteorite has found that certain PAHs likely formed in the cold areas of space between stars rather than in hot regions near stars as was previously thought. The findings open new possibilities for studying life beyond Earth and the chemistry of objects in space. The only Australian members of an international research team, scientists from Curtin’s WA-Organic ...

Advanced computational tool for understanding quantum materials

Advanced computational tool for understanding quantum materials
2023-12-21
Researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME), Argonne National Laboratory, and the University of Modena and Reggio Emilia have developed a new computational tool to describe how the atoms within quantum materials behave when they absorb and emit light. The tool will be released as part of the open-source software package WEST, developed within the Midwest Integrated Center for Computational Materials (MICCoM) by a team led by Prof. Marco ...

Role of enzyme SMYD3 clarified in prostate cancer progression

2023-12-21
Prostate cancer is the most common cancer in men other than skin cancer, and more than 288,000 new cases are diagnosed every year, according to the American Cancer Society. The disease’s fatality rate has decreased by more than half since the 1990s, but there is still room for progress—especially in treating or preventing advanced, metastatic disease, which is much more likely to be fatal. A new paper published in Science Advances clarifies how an enzyme called SMYD3 may be involved in prostate ...

LAST 30 PRESS RELEASES:

Quantum ‘alchemy’ made feasible with excitons

‘Revoice’ device gives stroke patients their voice back

USF-led study: AI helps reveal global surge in floating algae

New method predicts asthma attacks up to five years in advance

Researchers publish first ever structural engineering manual for bamboo

National poll: Less than half of parents say swearing is never OK for kids

Decades of suffering: Long-term mental health outcomes of Kurdish chemical gas attacks

Interactional dynamics of self-assessment and advice in peer reflection on microteaching

When aging affects the young: Revealing the weight of caregiving on teenagers

Can Canada’s health systems handle increased demand during FIFA World Cup?

Autistic and non-autistic faces may “speak a different language” when expressing emotion

No clear evidence that cannabis-based medicines relieve chronic nerve pain

Pioneering second-order nonlinear vibrational nanoscopy for interfacial molecular systems beyond the diffraction limit

Bottleneck in hydrogen distribution jeopardises billions in clean energy

Lung cancer death rates among women in Europe are finally levelling off

Scientists trace microplastics in fertilizer from fields to the beach

The Lancet Obstetrics, Gynecology, & Women’s Health: Taking paracetamol during pregnancy does not increase risk of autism, ADHD or intellectual disabilities, confirms new gold-standard evidence review

Taking paracetamol during pregnancy does not increase risk of autism, ADHD or intellectual disabilities

Harm reduction vending machines in New York State expand access to overdose treatment and drug test strips, UB studies confirm

University of Phoenix releases white paper on Credit for Prior Learning as a catalyst for internal mobility and retention

Canada losing track of salmon health as climate and industrial threats mount

Molecular sieve-confined Pt-FeOx catalysts achieve highly efficient reversible hydrogen cycle of methylcyclohexane-toluene

Investment in farm productivity tools key to reducing greenhouse gas

New review highlights electrochemical pathways to recover uranium from wastewater and seawater

Hidden pollutants in shale gas development raise environmental concerns, new review finds

Discarded cigarette butts transformed into high performance energy storage materials

Researchers highlight role of alternative RNA splicing in schizophrenia

NTU Singapore scientists find new way to disarm antibiotic-resistant bacteria and restore healing in chronic wounds

Research suggests nationwide racial bias in media reporting on gun violence

Revealing the cell’s nanocourier at work

[Press-News.org] Despite use of tecovirimat since the beginning of the 2022 mpox outbreak, few data have been published on its antiviral effect in humans
This study predicts the impact of early tecovirimat administration on the time to viral clearance in patients with mpox infection, using an integrative modeling approach combining pre-clinical and clinical data