PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Acellular players in the high cryosphere: diversity, function and activity of the global supraglacial DNA viruses

Acellular players in the high cryosphere: diversity, function and activity of the global supraglacial DNA viruses
2023-12-28
(Press-News.org) Supraglacial environments mainly consist of four main types of habitats for microbes and viruses, including snow, ice, meltwater, and cryoconites (the granular sediment on glacier surfaces). The paper revealed that there were more than 10,000 viral species in global supraglacial environments. This is a 15-fold expansion of DNA viral genomic inventory ever known. These viruses mainly belong to bacteriophages, viruses infecting bacteria. Liu et al., also found the viral communities showed a clear regional and habitat distribution pattern, with polar glacier samples separated from mountain glaciers of the Tibetan Plateau and cryoconites samples separated from snow and ice.

In addition, this work revealed a vigorous viral host interaction in supraglacial environments.

They found that supraglacial viruses could be linked to ~83% of obtained prokaryotic phyla/classes and possessed the genetic potential to promote metabolism and increase cold adaptation, cell mobility, and phenolic carbon use of hosts in hostile environmental conditions using diverse auxiliary metabolic genes. The on-site measurements carried out by Liu et al. showed that the virus production rate could reach 2×108 VLPs g−1 h−1, which is similar to global ocean and freshwater lakes.

Finally, a thorough analysis of viral genomic content revealed that supraglacial DNA viruses as shuttles for Antibiotic resistance genes (ARGs) and virulence factors (VFs). Liu et al. detected 122 (1.1% of total viral species) and 924 unique viral species (8.6% of total viral species) carrying 31 unique ARG types and 1405 VFs coding genes. Hence, supraglacial DNA viruses might serve as mobile genetic elements for ARGs and VFs in glacier ecosystems.

In conclusion, this study provides a systematic view of the diversity and function of mountain and polar supraglacial DNA viruses. It emphasized the importance of viruses in supraglacial biogeochemical cycling and their potential impacts on downstream ecosystem sustainability. This study expands our knowledge of the diversity, function, and adaptability of supraglacial viruses, and provides a basis for future research on the world’s glaciers.

END

[Attachments] See images for this press release:
Acellular players in the high cryosphere: diversity, function and activity of the global supraglacial DNA viruses

ELSE PRESS RELEASES FROM THIS DATE:

A carbon-lite atmosphere could be a sign of water and life on other terrestrial planets, MIT study finds.

2023-12-28
Scientists at MIT, the University of Birmingham, and elsewhere say that astronomers’ best chance of finding liquid water, and even life on other planets, is to look for the absence, rather than the presence, of a chemical feature in their atmospheres.  The researchers propose that if a terrestrial planet has substantially less carbon dioxide in its atmosphere compared to other planets in the same system, it could be a sign of liquid water — and possibly life — on that planet’s surface.  What’s more, this new signature is within the sights of NASA’s James Webb Space Telescope (JWST). While scientists have proposed ...

Insilico announces the expansion of its oncology pipelines and delivers the new generation FGFR2/3 inhibitor

Insilico announces the expansion of its oncology pipelines and delivers the new generation FGFR2/3 inhibitor
2023-12-28
- The nomination of the new generation of FGFR2/3 inhibitor for the treatment of tissue-agnostic solid tumors, bringing the total number of PCCs nominated by Insilico in 2023 to six.  - ISM8001 is an oral, highly selective, covalent inhibitor that demonstrated superior potency in multiple FGFR2/3-driven efficacy models, and also in gatekeeper and molecular brake mutant resistant models.  - The program once again demonstrates Insilico's ability to efficiently generate novel molecules with high quality that are currently available for partnering.   Insilico Medicine ("Insilico"), a generative artificial intelligence (AI)-driven clinical-stage drug discovery ...

Liso-cel is a cost effective second-line treatment for common form of lymphoma

2023-12-28
(WASHINGTON, Dec. 28, 2023) – Lisocabtagene maraleucel (liso-cel), a CAR T-cell therapy, is a cost effective second line treatment for relapsed and refractory (hard to treat) diffuse large B-cell lymphoma (r/r DLBCL), according to a study published today in Blood Advances. The study is the first of its kind to incorporate healthcare expenses, societal productivity losses, and patient quality of life in assessing the drug’s cost-effectiveness. "In our study, we incorporated the often-overlooked societal costs associated with cancer treatment, which are typically neglected in ...

A team from the UPV and CSIC discovers a new method for generating metal nanoparticles for use as catalysts

A team from the UPV and CSIC discovers a new method for generating metal nanoparticles for use as catalysts
2023-12-28
This new method is based on the exsolution process activated by microwave radiation. Exsolution is a method of generating metallic nanoparticles on the surface of ceramic materials. "At elevated temperatures and in a reducing atmosphere (usually hydrogen), metal atoms migrate from the structure of the material to its surface, forming metal nanoparticles anchored to the surface. This anchoring significantly increases the strength and stability of these nanoparticles, which positively impacts the efficiency of these catalysts," explains Beatriz García Baños, a researcher in the Microwave Area of the ITACA Institute at the UPV. In the work now ...

Cancer test shows promise for bringing the benefits of immunotherapy to more patients

2023-12-28
Brigham researchers’ findings from next-generation sequencing suggest that revising current cancer care guidelines could allow approximately 6,000 more patients in the U.S. to benefit from immunotherapy treatment each year Immunotherapy is a highly effective treatment for patients whose cancers harbor mismatch repair deficiency, and a new study identifies more cancer patients who could benefit from this form of therapy. Investigators from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, found that nearly six percent of endometrial cancer patients and one percent of colorectal cancer patients with mismatch repair deficiency were ...

Medicaid coverage of physical, behavioral health together does not improve access, care

2023-12-28
Health care systems in the United States have gradually embraced the concept that mental health should be treated on par with physical health, especially in light of increased rates of anxiety and depression during and after the COVID-19 pandemic. To improve access to mental health treatment, many Medicaid programs have required their managed care organizations to pay for behavioral health and physical health together. That’s in contrast to the traditional approach in which behavioral health, including treatment for substance use disorders, was “carved out” ...

Scientists discover new way to identify liquid water on exoplanets

2023-12-28
Scientists have devised a new way to identify habitable planets and potentially inhabited planets, by comparing the amount of carbon dioxide in their atmosphere, to neighbouring planets. An international team of researchers from the University of Birmingham (UK), the Massachusetts Institute of Technology (MIT) (US) and elsewhere, have shown that if a planet has a reduced amount of CO2 in its atmosphere compared to neighbouring planets, it suggests there is liquid water on that planet’s surface. The drop in CO2 levels implies ...

Developing nanocatalysts to overcome limitations of water electrolysis technology

Developing nanocatalysts to overcome limitations of water electrolysis technology
2023-12-28
Green hydrogen can be produced through water electrolysis technology, which uses renewable energy to split water into hydrogen and oxygen without emitting carbon dioxide. However, the production cost of green hydrogen is currently around $5 per kilogram, which is two to three times higher than gray hydrogen obtained from natural gas. For the practical use of green hydroten, the innovation in water electrolysis technology is required for the realization of hydrogen economy, especially for Korea where the utilization ...

Blood poisoning keeping many people out of work

2023-12-28
A few years ago, the World Health Organization estimated that blood poisoning, or sepsis, is involved in one in five deaths in the world. 11 million people die from sepsis each year, of which nearly 3 million are children. This is also a problem in Norway, with thousands of people affected every year. “Sepsis is a severe immunological overreaction to an infection. It causes the body’s organs to fail,” says Nina Vibeche Skei. She is a doctoral research fellow at the Norwegian University of Science and Technology (NTNU) and a senior anaesthetist ...

Oral peptides: A new era in drug development

Oral peptides: A new era in drug development
2023-12-28
For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat surfaces or require specificity for particular protein homologs. Typically, larger biologics that can target these proteins demand injection, limiting patient convenience and accessibility. In a new study published in Nature Chemical Biology, scientists from the laboratory of Professor Christian Heinis at EPFL have achieved a significant milestone in drug development. Their research ...

LAST 30 PRESS RELEASES:

Public take the lead in discovery of new exploding star

What are they vaping? Study reveals alarming surge in adolescent vaping of THC, CBD, and synthetic cannabinoids

ECMWF - delivering forecasts over 10 times faster and cutting energy usage by 1000

Brazilian neuroscientist reveals how viral infections transform the brain through microscopic detective work

Turning social fragmentation into action through discovering relatedness

Cheese may really be giving you nightmares, scientists find

Study reveals most common medical emergencies in schools

Breathable yet protective: Next-gen medical textiles with micro/nano networks

Frequency-engineered MXene supercapacitors enable efficient pulse charging in TENG–SC hybrid systems

Developed an AI-based classification system for facial pigmented lesions

Achieving 20% efficiency in halogen-free organic solar cells via isomeric additive-mediated sequential processing

New book Terraglossia reclaims language, Country and culture

The most effective diabetes drugs don't reach enough patients yet

Breast cancer risk in younger women may be influenced by hormone therapy

Strategies for staying smoke-free after rehab

Commentary questions the potential benefit of levothyroxine treatment of mild hypothyroidism during pregnancy

Study projects over 14 million preventable deaths by 2030 if USAID defunding continues

New study reveals 33% gap in transplant access for UK’s poorest children

Dysregulated epigenetic memory in early embryos offers new clues to the inheritance of polycystic ovary syndrome (PCOS)

IVF and IUI pregnancy rates remain stable across Europe, despite an increasing uptake of single embryo transfer

It takes a village: Chimpanzee babies do better when their moms have social connections

From lab to market: how renewable polymers could transform medicine

Striking increase in obesity observed among youth between 2011 and 2023

No evidence that medications trigger microscopic colitis in older adults

NYUAD researchers find link between brain growth and mental health disorders

Aging-related inflammation is not universal across human populations, new study finds

University of Oregon to create national children’s mental health center with $11 million federal grant

Rare achievement: UTA undergrad publishes research

Fact or fiction? The ADHD info dilemma

Genetic ancestry linked to risk of severe dengue

[Press-News.org] Acellular players in the high cryosphere: diversity, function and activity of the global supraglacial DNA viruses