Diabetes medication class tied to lower risk of kidney stones
Mass General Brigham researchers found that among patients with type 2 diabetes, those who began taking SGLT2 inhibitors had lower rates of kidney stones compared to patients who began taking other classes of diabetes medications
2024-01-31
(Press-News.org) Rates of kidney stones are on the rise in the United States and around the world. Type 2 diabetes is associated with increased risk of kidney stones, but some forms of treatment for this condition may also have the benefit of lowering risk of kidney stones. In a study led by investigators from Mass General Brigham, researchers found that there was an association between the use of sodium-glucose contratransporter 2 (SGLT2) inhibitors and a lower risk of developing kidney stones. Their findings are reported in JAMA Internal Medicine.
Researchers from Brigham and Women’s Hospital and Massachusetts General Hospital, founding members of the Mass General Brigham healthcare system, worked together to conduct the analysis. The study included data from three nationwide databases of patients with type 2 diabetes who were seen in routine clinical practice. The team analyzed information from 716,406 adults with type 2 diabetes who had started taking an SGLT2 inhibitor or two other classes of diabetes medications known as GLP1 receptor agonists or dipeptidyl peptidase 4 (DPP4) inhibitors. Patients who began taking SGLT2 inhibitors had a 30 percent lower risk of developing kidney stones than those taking GLP1 agonists and about a 25 percent lower risk than those taking DPP4 inhibitors. The findings were consistent across sex, race/ethnicity, history of chronic kidney disease and obesity.
“Our findings could help inform clinical decision making for patients with diabetes who are at risk for developing kidney stones,” said corresponding author Julie Paik, MD, ScD, MPH, of the Division of Pharmacoepidemiology and Pharmacoeconomics and the Division of Renal (Kidney) Medicine at Brigham and Women’s Hospital.
Authorship: Additional Mass General Brigham authors include Helen Tesfaye (BWH) Gary C. Curhan (BWH), Heidi Zakoul (BWH), Deborah J. Wexler (MGH) and Elisabetta Patorno (BWH).
Disclosures: Curhan reported receiving personal fees as an employee of OM1 Inc, royalties from UpToDate and grants from GlaxoSmithKline outside of the submitted work. Wexler reported receiving personal fees from Novo Nordisk outside of the submitted work. Patorno reported receiving grants to her institution from Boehringer Ingelheim outside of the submitted work.
Funding: This study was funded by the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, the National Institute of Aging (K08AG055670) the Patient-Centered Outcomes Research Institute (DB-2020C2-2036), the US Food and Drug Administration (5U01FD007213), and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR075117).
Paper cited: Paik JM et al. “Sodium-Glucose Cotransporter 2 Inhibitors and Nephrolithiasis Risk in Patients With Type 2 Diabetes” JAMA Internal Medicine DOI: 10.1001/jamainternmed.2023.7660
###
About Mass General Brigham
Mass General Brigham is an integrated academic health care system, uniting great minds to solve the hardest problems in medicine for our communities and the world. Mass General Brigham connects a full continuum of care across a system of academic medical centers, community and specialty hospitals, a health insurance plan, physician networks, community health centers, home care, and long-term care services. Mass General Brigham is a nonprofit organization committed to patient care, research, teaching, and service to the community. In addition, Mass General Brigham is one of the nation’s leading biomedical research organizations with several Harvard Medical School teaching hospitals. For more information, please visit massgeneralbrigham.org.
END
ELSE PRESS RELEASES FROM THIS DATE:
2024-01-31
DURHAM, N.C. – A black sedan cruises silently down a quiet suburban road, driver humming Christmas carols quietly while the car’s autopilot handles the driving. Suddenly, red flashing lights and audible warnings blare to life, snapping the driver from their peaceful reprieve. They look at the dashboard screen and see the outline of a car speeding toward them for a head-on collision, yet the headlights reveal nothing ahead through the windshield.
Despite the incongruity, the car’s autopilot grabs control and swerves into a ditch. Exasperated, the driver looks around the vicinity, ...
2024-01-31
Strong support for Ukraine means there is “little space” for European politicians to exploit pro-Russia foreign policy messages, a new study shows.
Researchers have found widespread backing for Ukraine across the continent, and for policies that help the nation, such as imposing sanctions on Russia.
But public opinion is more mixed on the approach NATO should take and whether Ukraine should become a member.
Experts found European nations can be classified into three distinct groups. Citizens ...
2024-01-31
You might think age-related dementia has been with us all along, stretching back to the ancient world.
But a new analysis of classical Greek and Roman medical texts suggests that severe memory loss — occurring at epidemic levels today — was extremely rare 2,000 to 2,500 years ago, in the time of Aristotle, Galen and Pliny the Elder.
The USC-led research, published in the Journal of Alzheimer’s Disease, bolsters the idea that Alzheimer’s disease and related dementias are diseases of modern environments and lifestyles, with sedentary behavior and exposure to air pollution largely to blame.
“The ancient Greeks had very, very few — but we found them ...
2024-01-31
Does the type of solution used by surgeons to disinfect skin before surgery impact the risk of surgical site infection? According to new research from an international trial jointly led by McMaster University and the University of Maryland School of Medicine – yes, it does.
Researchers of the PREPARE trial, which enrolled nearly 8,500 participants at 25 hospitals in Canada and the United States, found the use of iodine povacrylex in alcohol to disinfect a patient’s skin could prevent surgical site infection in thousands of patients undergoing surgery for a closed ...
2024-01-31
UNIVERSITY PARK, Pa. — Trees are struggling to sequester heat-trapping carbon dioxide (CO2) in warmer, drier climates, meaning that they may no longer serve as a solution for offsetting humanity’s carbon footprint as the planet continues to warm, according to a new study led by Penn State researchers.
“We found that trees in warmer, drier climates are essentially coughing instead of breathing,” said Max Lloyd assistant research professor of geosciences at Penn State and lead author on the study recently published in Proceedings of the National Academy of Sciences. “They are sending CO2 right back into the ...
2024-01-31
From the study:
This research examines the anti-aging potential of the flavonoid derivative of isoquercitrin known as enzymatically modified isoquercitrin (EMIQ).
A 28-day clinical trial with 30 volunteers aged 31–55 years highlighted EMIQ's effectiveness. Participants using EMIQ-containing Essence displayed reduced facial trans-epidermal water loss and skin roughness, alongside improved skin elasticity. This study emphasizes EMIQ's potential as an anti-photoaging ingredient in cosmetics, warranting further research. The findings pave the way for developing innovative skincare products addressing photoaging effects. ...
2024-01-31
Ketamine has received a lot of attention as a potential treatment for depression, but few studies have revealed how well it works in real world settings, especially in patients with complex mental health needs.
Now, a new study of data from veterans who had tried many depression treatments but still had severe symptoms suggests a series of intravenous doses of ketamine gave many at least partial relief. For a minority, it led to full remission.
Nearly half of 215 veterans with treatment resistant depression who received ...
2024-01-31
Protein molecules lie at the heart of biology. Our typical understanding of proteins states that each type of protein has a specific three-dimensional shape that enables it to perform its function. This dogma is challenged by intrinsically disordered proteins which make up one third of all proteins and have central biological functions even though their shapes are constantly changing. Until now, our understanding of the structural properties of this intriguing class of proteins has been based on studies ...
2024-01-31
A team of scientists from the University of Ottawa, and researchers from other universities and research centres around the world, have discovered that 7-dehydrocholesterol (7-DHC) is an endogenous suppressor of ferroptosis, which could have important implications for the treatment of cell death-related diseases.
Ferroptosis is a form of cell death that is characterized by the accumulation of lipid peroxides and iron-dependent reactive oxygen species (ROS) in cells. It is a regulated process that is distinct from other forms of cell death, such as apoptosis and necrosis.
The researchers identified a pro-ferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) ...
2024-01-31
Calling out discriminatory behavior is an effective way for white students to help combat racism against Black and Latino science, technology, engineering and math (STEM) students, according to new research from Rice University.
“(Absent) Allyship in STEM: Can Psychological Standing Increase Prejudice Confrontation?” appears in a recent edition of the Journal of Business and Psychology. The research, led by Eden King and Mikki Hebl from Rice, examines whether Black and Latino college students face discrimination when studying STEM and how allies can help combat racist behavior in these situations.
“There is already a serious lack of representation ...
LAST 30 PRESS RELEASES:
[Press-News.org] Diabetes medication class tied to lower risk of kidney stones
Mass General Brigham researchers found that among patients with type 2 diabetes, those who began taking SGLT2 inhibitors had lower rates of kidney stones compared to patients who began taking other classes of diabetes medications
