New study has promising results for anti-aging effects from enzymatically modified isoquercitrin

Ketamine has received a lot of attention as a potential treatment for depression, but few studies have revealed how well it works in real world settings, especially in patients with complex mental health needs.  Now, a new study of data from veterans who had tried many depression treatments but still had severe symptoms suggests a series of intravenous doses of ketamine gave many at least partial relief. For a minority, it led to full remission.  Nearly half of 215 veterans with treatment resistant depression who received ...

Protein molecules lie at the heart of biology. Our typical understanding of proteins states that each type of protein has a specific three-dimensional shape that enables it to perform its function. This dogma is challenged by intrinsically disordered proteins which make up one third of all proteins and have central biological functions even though their shapes are constantly changing. Until now, our understanding of the structural properties of this intriguing class of proteins has been based on studies ...

A team of scientists from the University of Ottawa, and researchers from other universities and research centres around the world, have discovered that 7-dehydrocholesterol (7-DHC) is an endogenous suppressor of ferroptosis, which could have important implications for the treatment of cell death-related diseases. Ferroptosis is a form of cell death that is characterized by the accumulation of lipid peroxides and iron-dependent reactive oxygen species (ROS) in cells. It is a regulated process that is distinct from other forms of cell death, such as apoptosis and necrosis. The researchers identified a pro-ferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) ...

Calling out discriminatory behavior is an effective way for white students to help combat racism against Black and Latino science, technology, engineering and math (STEM) students, according to new research from Rice University. “(Absent) Allyship in STEM: Can Psychological Standing Increase Prejudice Confrontation?” appears in a recent edition of the Journal of Business and Psychology. The research, led by Eden King and Mikki Hebl from Rice, examines whether Black and Latino college students face discrimination when studying STEM and how allies can help combat racist behavior in these situations. “There is already a serious lack of representation ...

Research Highlights: An analysis of cardiac arrest records in a U.S. registry revealed that people with drug overdose cardiac arrests were more likely to be younger, have fewer health conditions and have higher survival rates with better neurologic outcomes compared to people who experience cardiac arrest from other causes. In addition, drug overdose cardiac arrests were less likely to be witnessed and less likely to present with a shockable first monitored heart rhythm, meaning a heart rhythm that is able to respond to a defibrillator. Embargoed until 4 a.m. CT/5 a.m. ET Wednesday, January 31, 2024 DALLAS, Jan. 31, 2024 — An analysis of data for more ...

EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, JANUARY 31, 2024 MINNEAPOLIS – Radon is the second leading cause of lung cancer. Now a new study has found exposure to this invisible, odorless gas is also linked to an increased risk of stroke. The study, which examined exposures in middle age to older female participants, found an increased risk of stroke among those exposed to high and even moderate concentrations of the gas compared to those exposed to the lowest concentrations. The study is published in the January 31, 2024, online issue of Neurology®, ...

EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, JANUARY 31, 2024 MINNEAPOLIS – People with polycystic ovary syndrome may be more likely to have memory and thinking problems in middle age, according to new research published in the January 31, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study does not prove that polycystic ovary syndrome causes cognitive decline. It only shows an association. Polycystic ovary syndrome is a hormonal disorder that is defined by irregular menstruation and elevated levels of a hormone called androgen. Other symptoms may include excess hair growth, acne, infertility and poor metabolic ...

Rochester Institute of Technology scientists will be the lead researchers on a $1.8 million NASA grant to study electromagnetic signals from merging supermassive black holes. RIT’s Manuela Campanelli, Distinguished Professor in the School of Mathematics and Statistics and director of the Center for Computational Relativity and Gravitation, will lead the collaborative project with help from Yosef Zlochower, professor in the School of Mathematics and Statistics. The project will also include researchers from the University of Idaho, Johns Hopkins University, and the Goddard Space Flight Center. The team will combine astrophysical knowledge with state-of-the-art ...

Indiana University researchers in the College of Arts and Sciences in Bloomington have identified a missing link that can help protect the brain from aging. Hui-Chen Lu, professor and director of the Linda and Jack Gill Center for Biomolecular Science at IU, alongside graduate students Sen Yang and Zhen Xian Niou, found that nicotinamide nucleotide adenylyl transferase 2, or NMNAT2, provides energy to axons independent of the mitochondria. It does this by propelling glycolysis, a process in which glucose is broken down to produce energy. This gives axons enough energy to ...

AURORA, Co. (January 31, 2024) - A collaborative cohort of researchers, led by University of Colorado Anschutz Medical Campus professor Angelo D’Alessandro, have identified kynurenine as a critical new biomarker in the quality of stored red blood cells (RBCs), a crucial step in the development of more personalized transfusions. Study results published today in the journal Blood.  The transfusion of RBCs is one of the most common in-hospital medical procedures second only to vaccination. The blood supply is dependent on altruistic blood donors, and donated RBCs are stored ...