(Press-News.org) A team of researchers from the Badalona Applied Research Group in Oncology (B·ARGO) and the Urologic Tumours Unit of the Institut Català d'Oncologia (ICO) and the Germans Trias i Pujol Research Institute (IGTP) have found a new therapeutic strategy for patients with a specific subtype of metastatic prostate cancer resistant to standard chemotherapy treatment with docetaxel.
In this study, published in the journal Frontiers in Pharmacology, they propose a new treatment based on a combination of kinase inhibitors in patients who inevitably stop responding to docetaxel. The team found that resistance to this drug is associated with the hyperactivation of the cellular pathways PI3K/AKT and MEK/ERK and have explored the possibility of inhibiting these pathways as a new therapeutic strategy in patients who maintain the function of PTEN, a negative regulatory protein of the PI3K/AKT pathway.
The results of the study have been satisfactory and, for this reason, the team wants to conduct a clinical trial to assess the safety and efficacy of this combination in patients with prostate cancer resistant to docetaxel. Vicenç Ruiz de Porras and Adrià Bernat-Peguera, ICO-IGTP researchers and co-first authors of the study, state that the results of this study "open the door to a new therapeutic strategy for those patients with PTEN wild-type tumors, who have progressed to docetaxel and in whom, unlike PTEN null patients, the efficacy of AKT inhibitors in monotherapy has not been demonstrated."
END
New therapeutic strategy for metastatic prostate cancer patients resistant to standard treatment
A team of researchers has identified a combination of drugs that could change the treatment of patients with prostate cancer resistant to the drug docetaxel
2024-02-02
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
Audiogene, the first clinical trial in France for a gene therapy to treat hearing loss in children
2024-02-02
The aim of this clinical trial, which has just received approval in France, is to assess the safety and efficacy of a new gene therapy drug in children aged between 6 and 31 months with profound hearing loss. Audiogene was developed by a French consortium composed of teams from the Hearing Institute, an Institut Pasteur research center; the ENT Department and Pediatric Audiology Research Center at Necker-Enfants Malades Hospital (AP-HP); Sensorion and Fondation Pour l'Audition. The trial has also been submitted to other European countries and is currently undergoing assessment.
Audiogene is the first clinical trial in France to test a gene therapy drug, SENS-501, ...
Vaccine targeting KRAS in pancreatic and colorectal cancer shows promise
2024-02-02
A new vaccine shows encouraging early results as a potential off-the-shelf treatment for certain patients with pancreatic or colorectal cancer, according to a study co-led by researchers at Memorial Sloan Kettering Cancer Center (MSK). The vaccine targets tumors with mutations (or changes) in the KRAS gene, a driving force in many cancers.
This cancer vaccine is different from another type of pancreatic cancer vaccine, which is custom-made for each patient using messenger RNA (mRNA). Both are therapeutic vaccines given after surgery ...
A physical qubit with built-in error correction
2024-02-02
There has been significant progress in the field of quantum computing. Big global players, such as Google and IBM, are already offering cloud-based quantum computing services. However, quantum computers cannot yet help with problems that occur when standard computers reach the limits of their capacities because the availability of qubits or quantum bits, i.e., the basic units of quantum information, is still insufficient. One of the reasons for this is that bare qubits are not of immediate use for running a quantum algorithm. While the binary bits of customary computers store information in the form of fixed values of either 0 or 1, qubits can represent 0 and ...
Biodegradable sensor monitors levels of pesticides via direct contact with surface of fruit and vegetables
2024-02-02
Researchers at the University of São Paulo (USP) and the Federal University of Viçosa (UFV) in Brazil have developed a sustainable sensor that can be placed directly on the surface of a vegetable or fruit to detect the presence of pesticides. Known for this reason as “plant-wearable”, it is made of cellulose acetate, a material derived from wood pulp.
The device has the potential to help assure food safety in a world that increasingly suffers from a shortage of food and the environmental and health problems caused ...
Paper: Multistate foodborne illness outbreaks impact restaurant stock price, public perception
2024-02-02
CHAMPAIGN, Ill. — As demand for food from restaurants soars in the U.S., so does the importance in understanding the impacts of foodborne illness outbreaks. A new paper co-written by a University of Illinois Urbana-Champaign expert in food marketing and food policy finds that outbreaks spanning multiple states bring swift financial losses, increased media attention and a public-relations hit that makes smaller outbreaks more financially damaging.
In the U.S., more than 60% of foodborne illness outbreaks occur at restaurants, and the vast majority of those outbreaks are confined ...
Identifying genomics markers to predict radiation sensitivity
2024-02-02
As the effectiveness of radiotherapy varies greatly between tumours, finding gene signatures to predict the radiation response could better guide the clinicians to personalize treatment plans. Professor Venkata Manem, affiliated with the Faculty of Medicine at Université Laval and the Centre de recherche CHU de Québec - Université Laval, has made a promising step to advance pre-clinical research in the field of precision radiation oncology.
Currently, doctors use a “one-size-fits-all” paradigm for radiotherapy, with a given dose and frequency ...
Turban style and thickness affects head injury risk in Sikh cyclists
2024-02-02
Sudden impacts or jolts to the head can cause skull fractures and traumatic brain injuries (TBIs). TBIs can cause bleeding, unconsciousness, and potential changes to the brain leading to memory loss, mood and personality changes and lack of concentration - sometimes many years after the initial injury.
However, very little research has been done to ascertain the extent and mechanism by which turbans might mitigate impacts to the head during cycling incidents.
Now, researchers from Imperial and the Sikh Scientists Network have studied the performance of turban styles ...
Scientists successfully simulate protein complex that initiates fertilization
2024-02-02
Who hasn't seen it before: the view through the microscope in which a sperm penetrates an egg cell and fertilises it. This fundamental step in procreation happens dynamically and seemingly without problems. However, if you zoom in on the processes that take place during fertilisation at a molecular level, it becomes highly complex and it is thus not surprising that 15 percent of couples worldwide struggle to conceive. No microscope, however modern, can illuminate the countless interactions between the proteins involved. Therefore, the exact trigger for the fertilisation process and the molecular events that transpire just before the fusion of the sperm and egg have ...
Immune cells lose ‘killer instinct’ in cancerous tumors – but functionality can be re-awakened
2024-02-02
Some immune cells in our bodies see their ‘killer instinct’ restricted after entering solid tumours, according to new research.
In a new paper published in Nature Communications, a team led by researchers from the University of Birmingham and the University of Cambridge found how immune cells called natural killer cells (NK cells) rapidly lose their functionality when entering and residing in tumours.
Using tumour cells grown from mice models, the team established that NK cells adopt a dormant state when entering solid tumours through the loss of production of key effector mechanisms used to promote immune ...
Did climate change trigger pandemics in antiquity?
2024-02-02
For their study in Science Advances, the researchers reconstructed temperatures and precipitation for the period from 200 BC to 600 AD, with a resolution of three years. This means that two data points cover a period of three years – an extremely high resolution for paleoclimate researchers. The period extends from the so-called Roman Climatic Optimum to the Late Antique Little Ice Age. This period also includes three major pandemics known from historians’ records: the Antonine Plague (around 165 to 180 AD), the Cyprian Plague (around 251 to 266) and the Justinian ...
LAST 30 PRESS RELEASES:
ASH 2025: AI uncovers how DNA architecture failures trigger blood cancer
ASH 2025: New study shows that patients can safely receive stem cell transplants from mismatched, unrelated donors
Protective regimen allows successful stem cell transplant even without close genetic match between donor and recipient
Continuous and fixed-duration treatments result in similar outcomes for CLL
Measurable residual disease shows strong potential as an early indicator of survival in patients with acute myeloid leukemia
Chemotherapy and radiation are comparable as pre-transplant conditioning for patients with b-acute lymphoblastic leukemia who have no measurable residual disease
Roughly one-third of families with children being treated for leukemia struggle to pay living expenses
Quality improvement project results in increased screening and treatment for iron deficiency in pregnancy
IV iron improves survival, increases hemoglobin in hospitalized patients with iron-deficiency anemia and an acute infection
Black patients with acute myeloid leukemia are younger at diagnosis and experience poorer survival outcomes than White patients
Emergency departments fall short on delivering timely treatment for sickle cell pain
Study shows no clear evidence of harm from hydroxyurea use during pregnancy
Long-term outlook is positive for most after hematopoietic cell transplant for sickle cell disease
Study offers real-world data on commercial implementation of gene therapies for sickle cell disease and beta thalassemia
Early results suggest exa-cel gene therapy works well in children
NTIDE: Disability employment holds steady after data hiatus
Social lives of viruses affect antiviral resistance
Dose of psilocybin, dash of rabies point to treatment for depression
Helping health care providers navigate social, political, and legal barriers to patient care
Barrow Neurological Institute, University of Calgary study urges “major change” to migraine treatment in Emergency Departments
Using smartphones to improve disaster search and rescue
Robust new photocatalyst paves the way for cleaner hydrogen peroxide production and greener chemical manufacturing
Ultrafast material captures toxic PFAS at record speed and capacity
Plant phenolic acids supercharge old antibiotics against multidrug resistant E. coli
UNC-Chapel Hill study shows AI can dramatically speed up digitizing natural history collections
OYE Therapeutics closes $5M convertible note round, advancing toward clinical development
Membrane ‘neighborhood’ helps transporter protein regulate cell signaling
Naval aviator turned NPS doctoral student earns national recognition for applied quantum research
Astronomers watch stars explode in real time through new images
Carbon-negative building material developed at Worcester Polytechnic Institute published in matter
[Press-News.org] New therapeutic strategy for metastatic prostate cancer patients resistant to standard treatmentA team of researchers has identified a combination of drugs that could change the treatment of patients with prostate cancer resistant to the drug docetaxel