(Press-News.org) HOUSTON ― A specific combination of targeted therapy and immunotherapy may better help patients with non-small cell lung cancer (NSCLC) overcome inherent immune resistance and reinvigorate anti-tumor activity, according to a new study led by a researcher from The University of Texas MD Anderson Cancer Center.
Results from the Phase II umbrella HUDSON study, published today in Nature Medicine, demonstrated that the anti PD-L1 antibody, durvalumab, coupled with the ATR inhibitor, ceralasertib, provided the greatest clinical benefit of four combinations evaluated.
This pair had an objective response rate (ORR) of 13.9% compared to just 2.6% with the other tested combinations. Median progression-free survival (PFS) was 5.8 months versus 2.7 months for other combinations, while median overall survival (OS) was 17.4 months versus 9.4 months. In patients with ATM alterations, which should sensitize tumors to ATR inhibitors, the ORR increased to 26.1%. Durvalumab-ceralasertib had a manageable safety profile.
"Patients with advanced non-small cell lung cancer face significant challenges when standard-of-care treatments fail," said corresponding author John Heymach, M.D., Ph.D., chair of Thoracic/Head & Neck Medical Oncology. "For these individuals, options become limited, emphasizing the urgent need for innovative approaches. Our study represents a promising advancement in addressing this unmet need and holds the potential to offer more effective therapeutic strategies to improve outcomes for this population."
This study enrolled 268 patients with advanced NSCLC who progressed following standard-of-care therapy. The median age of participants was 63-64 years; 58% were male.
Patients on the trial received one of four targeted therapies in combination with durvalumab: ceralasertib (ATR kinase inhibitor), olaparib (PARP inhibitor), danvatirsen (STAT3 antisense oligonucleotide) or oleclumab (anti-CD73 monoclonal antibody).
Tumor molecular characteristics were analyzed before treatment, and patients were categorized into biomarker-matched or -unmatched treatment cohorts based on ATM alterations, homologous recombination repair defects, STK11/LKB1 alterations, or high CD73 expression.
Based on the results, durvalumab plus ceralasertib is now being tested in a randomized Phase III trial for patients with immunotherapy-refractory NSCLC.
This trial was supported by AstraZeneca. A full list of authors and their disclosures can be found with the full paper here.
Read this press release in the MD Anderson Newsroom.
END
Biomarker-directed combination effective in immunotherapy-resistant lung cancer
Phase II trial finds durvalumab plus ceralasertib boosted immune response and improved outcomes in patients with lung cancer
2024-02-13
ELSE PRESS RELEASES FROM THIS DATE:
Plant-based diet tied to improved sexual health in men treated for prostate cancer
2024-02-13
A diet that limits meat and dairy but is rich in fruits, vegetables, grains, and nuts is linked to less erectile dysfunction, urinary incontinence, and other common side effects seen in prostate cancer patients, a new study shows.
Led by researchers at NYU Grossman School of Medicine and Harvard T.H. Chan School of Public Health, the analysis of more than 3,500 men with prostate cancer explored whether eating a more plant-based diet was associated with quality-of-life issues that often arise after treatment. Sorting patients into five groups (quintiles) based on the proportion of plant versus animal foods the men said they eat, the authors found ...
Quality of care for patients who call 911 varies greatly across the United States, study finds
2024-02-13
Emergency medical service (EMS) systems are not consistently providing optimal care based on new national standards of quality to patients who call 911, according to a new study from the Icahn School of Medicine of Mount Sinai.
The study demonstrates that EMS performance on key clinical and patient safety measures varies widely across urban and rural communities. The findings, published in the peer-reviewed Prehospital Emergency Care, identify opportunities that could lead to improved care during 911 responses and improved outcomes for patients across the United States.
“EMS systems in the United States have traditionally relied ...
CRISPR-copies: New tool accelerates and optimizes genome editing
2024-02-13
CRISPR/Cas systems have undergone tremendous advancement in the past decade. These precise genome editing tools have applications ranging from transgenic crop development to gene therapy and beyond. And with their recent development of CRISPR-COPIES, researchers at the Center for Advanced Bioenergy and Bioproducts Innovation (CABBI) are further improving CRISPR’s versatility and ease of use.
“CRISPR-COPIES is a tool that can quickly identify appropriate chromosomal integration sites for genetic engineering in any organism,” said Huimin Zhao, CABBI Conversion Theme Leader ...
Teenagers need better reproductive health education to tackle parenthood fears
2024-02-13
Nearly half of teenagers are worried about having children and many lack knowledge about their reproductive health, find two new studies by UCL researchers.
The studies, published in Human Fertility and Health Education Journal, used survey results from 931 students in England aged 16 to 18, collected between May 2021 and July 2022.
The Human Fertility paper found that a majority of students (64%) still wanted to have children in the future – with nearly half (49%) desiring to have two children.
However, 45% of all participants said that they had concerns about future ...
Data-driven app results in 25% fewer emergency hospital admissions from care homes
2024-02-13
The use of a digital remote monitoring technology in care homes has been found to reduce hospital A&E attendances by 11% and emergency admissions by 25% in a new study from the Health Data Research UK (HDR UK) Better Care programme, published today in Age and Ageing - the official journal of the British Geriatrics Society.
There are over 400,000 people living in care homes across the UK, many of whom will be living with complex medical needs that put them at greater risk of needing emergency healthcare, especially during the winter months.
Through the HDR UK Better Care programme, a collaboration between the universities ...
In rural states, gardening and foraging helped prevent hunger during COVID: Study
2024-02-13
New research on rural New Englanders shows that gardening, hunting, fishing and other HWFP activities are important tools for maintaining food security through extreme events, such as pandemics or climate change events.
University of Vermont and University of Maine researchers found that both food insecurity and home and wild food production (HWFP) – gardening, hunting, fishing, foraging, and having “backyard” poultry or livestock – increased significantly during the COVID-19 pandemic, and those who undertook HWFP activities exhibited improved food security 9-12 months later.
The paper, published in Scientific Reports, surveyed ...
New study finds roughly 1 in 10 pregnant people will develop long COVID
2024-02-13
UNDER EMBARGO UNTIL: Feb. 12, 2024 5:45 p.m. Eastern Standard Time
Media Contacts: Karen Addis, APR, karen@addispr.com, +1 (301) 787-2394; Kerri Wade, MPA, kwade@smfm.org, +1 ...
Differential expression of Mad2 gene in human esophageal cancer
2024-02-12
“[...] people of the northeastern region [of India] consume betel quid, consisting of raw areca nut [...]. People often swallow the entire betel-quid after chewing, which is believed to contribute to the development of oral, esophageal, and gastric cancers.”
BUFFALO, NY- February 12, 2024 – A new research paper was published in Oncotarget's Volume 15 on February 5, 2024, entitled, “Differential expression of Mad2 gene is consequential to the patterns of histone H3 post-translational modifications in its promoter region in human esophageal ...
RIT's Center for Detectors to work on two NASA projects
2024-02-12
Rochester Institute of Technology’s Center for Detectors has been chosen by NASA for two research programs: Early Stage Innovations (ESI) and Strategic Astrophysics Technology (SAT), with the hope of helping future spacecraft find new discoveries in the vast universe.
Under the leadership of Center for Detectors Director Don Figer, the team will be advancing and characterizing single-photon sensing complementary metal-oxide semiconductor (CMOS) image sensors to determine if they can survive the harsh radiation environments in NASA missions. The intent is to fly these types of detectors on future missions to find life on Jupiter’s ...
Archaeologists discover oldest known bead in the Americas
2024-02-12
University of Wyoming archaeology Professor Todd Surovell and his team of collaborators have discovered a tube-shaped bead made of bone that is about 12,940 years old.
The bead, found at the La Prele Mammoth site in Converse County, is the oldest known bead in the Americas.
Surovell’s research was published in the peer-reviewed journal Scientific Reports; the paper is titled “Use of hare bone for the manufacture of a Clovis bead.” Members of the research team included people from UW, the Office of the Wyoming State Archaeologist, the University of Manchester, Weber ...
LAST 30 PRESS RELEASES:
Carbon capture, utilization, and storage: A comprehensive review of CCUS-EOR
New high-temperature stable dispersed particle gel for enhanced profile control in CCUS applications
State gun laws and firearm-related homicides and suicides
Use of tobacco and cannabis following state-level cannabis legalization
Long-term obesity and biological aging in young adults
Eindhoven University of Technology and JMIR Publications announce unlimited open access publishing agreement
Orphan nuclear receptors in metabolic dysfunction-associated steatotic liver disease development
A technological breakthrough for ultra-fast and greener AI
Pusan National University researchers identify key barriers hindering data-driven smart manufacturing adoption
Inking heterometallic nanosheets: A scalable breakthrough for coating, electronics, and electrocatalyst applications
Adults with autism show similar brain mapping of body parts as typically developing adults
Uncovering behavioral clues to childhood maltreatment
Premenstrual symptoms linked to increased risk of cardiovascular disease
Newly discovered remains of ancient river landscapes control ice flow in East Antarctica
Newly discovered interstellar object 'may be oldest comet ever seen'
Animal-inspired AI robot learns to navigate unfamiliar terrain
Underserved youth less likely to visit emergency department for concussion in Ontario, study finds
‘Molecular shield’ placed in the nose may soon treat common hay fever trigger
Beetles under climate stress lay larger male eggs: Wolbachia infection drives adaptive reproduction strategy in response to rising temperature and CO₂
Groundbreaking quantum study puts wave-particle duality to work
Weekly injection could be life changing for Parkinson’s patients
Toxic metals linked to impaired growth in infants in Guatemala
Being consistently physically active in adulthood linked to 30–40% lower risk of death
Nerve pain drug gabapentin linked to increased dementia, cognitive impairment risks
Children’s social care involvement common to nearly third of UK mums who died during perinatal period
‘Support, not judgement’: Study explores links between children’s social care involvement and maternal deaths
Ethnic minority and poorer children more likely to die in intensive care
Major progress in fertility preservation after treatment for cancer of the lymphatic system
Fewer complications after additional ultrasound in pregnant women who feel less fetal movement
Environmental impact of common pesticides seriously underestimated
[Press-News.org] Biomarker-directed combination effective in immunotherapy-resistant lung cancerPhase II trial finds durvalumab plus ceralasertib boosted immune response and improved outcomes in patients with lung cancer