Second primary breast cancer in young breast cancer survivors

JAMA Oncology

2024-04-11

(Press-News.org) About The Study: The results of this study suggest that young breast cancer survivors without a germline pathogenic variant have a low risk of developing a second primary breast cancer in the first 10 years after diagnosis. Findings from germline genetic testing may inform treatment decision-making and follow-up care considerations in this population.

Authors: Kristen D. Brantley, Ph.D., M.P.H., of the Harvard T. H. Chan School of Public Health in Boston, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamaoncol.2024.0286)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2024.0286?guestAccessKey=69248d69-50fe-42e8-9b30-327dba0a1eb6&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=041124

END

ELSE PRESS RELEASES FROM THIS DATE:

Physician empathy and chronic pain outcomes

2024-04-11

About The Study: In this study that included 1,470 adults with chronic low back pain, physician empathy was associated with better outcomes over 12 months. Greater efforts to cultivate and improve physician empathy appear warranted. Authors: John C. Licciardone, D.O., M.S., M.B.A., of the University of North Texas Health Science Center at Fort Worth, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.6026) Editor’s ...

Tropical coral-infecting parasites discovered in cold marine ecosystems

2024-04-11

Parasites thought only to infect tropical coral reefs have been discovered in a large variety of creatures in cold marine ecosystems along the Northeast Pacific, according to new research from University of British Columbia botanists. The finding, published today in Current Biology, greatly expands the range of corallicolids, suggesting the parasites infect a range of organisms related to coral, like sea anemones and other cold-water marine invertebrates, around the world. “This highlights significant blind spots in our strategies designed to sample microbial biodiversity,” says University of British Columbia biodiversity researcher Dr. Patrick Keeling, senior author on the ...

Successful murine model of dermatomyositis reveals underlying immune system involvement

2024-04-11

Researchers from Tokyo Medical and Dental University (TMDU) have developed a murine model for a highly progressive disease called “anti-MDA5 antibody-positive dermatomyositis”, providing insights into underlying biological mechanisms and aiding treatment Tokyo, Japan – Some diseases involve autoimmune reactions, when the body begins to attack its own cells and proteins. The biological mechanisms underlying these diseases are often unknown, making treatment challenging. Now, a group at TMDU has created a murine model for a disease ...

Next-gen lab chip transforms cancer detection: triple-threat cell sorting unveiled

2024-04-11

Researchers have unveiled a microfluidic device that significantly improves the separation of tumor cells and clusters from malignant effusions. This novel technology promises to advance the diagnosis and treatment monitoring of cancer by enabling the high-throughput, continuous-flow ternary separation of single tumor cells, tumor cell clusters, and white blood cells (WBCs) from clinical pleural or abdominal effusions. Understanding the nature of malignant effusions, teeming with tumor cells and clusters, is critical in comprehending the breadth of cancer's impact. The significant role of tumor clusters, with their heightened potential ...

NCCN 2024 Annual Conference shares cancer care updates for practical, immediate use in practice

2024-04-11

PLYMOUTH MEETING, PA [April 11, 2024] — The National Comprehensive Cancer Network® (NCCN®)—an alliance of leading cancer centers—hosted more than 1,700 oncology professionals during the NCCN 2024 Annual Conference on April 5-7. The yearly meeting includes opportunities for care providers to interact with world-renowned specialists on the latest evidence-based expert consensus recommendations for delivering high quality, patient-centered cancer care. Sessions focused on practical applications for improving care at every level, including clinical and administrative ...

Genetic underpinnings of environmental stress identified in model plant

2024-04-11

Plants can be temperamental. Even weeds along the side of highways or pushing their way up in the cracks of concrete sidewalks can get stressed out by dehydration, cold, excess salt and more. Researchers at Hiroshima University have identified 14 genes that thale cress — a plant commonly used in genetic investigations since its genome is well documented — express more when responding to five specific stressors, as well as eight genes that the plant suppresses. They published their results on March 22 in Frontiers in Plant Science. “Abiotic stresses — as opposed to biotic stresses like pests or disease — such as drought, salinity and cold negatively ...

This outdated diabetes drug still has something to offer

2024-04-11

Thiazolidinediones (TZDs) are a class of drug that can be used to treat type 2 diabetes by reversing insulin resistance, one of the main hallmarks of the disease. While TZDs were extremely popular in the 1990’s and early 2000’s, they have fallen out of use among physicians in recent decades because they were discovered to cause unwanted side effects, including weight gain and excess fluid accumulation in body tissues. Now, researchers at University of California San Diego School of Medicine are ...

Developing best practices for human-AI collaboration in engineering design

2024-04-11

As artificial intelligence is inevitably woven into the workplace, teams of humans will increasingly collaborate with robots on complex design problems, such as those in the auto, aviation, and space industries. “Right now, design is mainly done by humans, and it’s based on their expertise and intuitive decision-making, which is learned over time,” says A. Emrah Bayrak, an assistant professor of mechanical engineering and mechanics in Lehigh University’s P.C. Rossin College of Engineering and Applied Science. “Usually, ...

Novel CT exam reduces need for invasive artery treatment

2024-04-11

OAK BROOK, Ill. – A new study showed that a non-invasive imaging test can help identify patients with coronary artery blockage or narrowing who need a revascularization procedure. The findings were published as a Special Report in Radiology: Cardiothoracic Imaging, a journal of the Radiological Society of North America (RSNA). Doctors use coronary CT angiography (CTA) to diagnose narrowed or blocked arteries in the heart. A CTA exam receives a score from mild (0-1) to moderate (2-3) to severe (4-5). Patients ...

ERC Advanced Grant: 2.5 million euros for Tobias Brixner

2024-04-11

Many people are familiar with the principle of electronic excitation from their physics lessons: electrons in atoms or molecules absorb energy, typically from light, and rise to a higher energy level. This can have various consequences – in photovoltaic technology, the phenomenon ensures that electricity can be generated from sunlight. Measuring electronic excitation according to scientific standards and investigating how excited electrons influence each other is a real challenge: “Electronic excitation and the subsequent processes take place extremely quickly, many things happen simultaneously“, explains Tobias Brixner, Chair of Physical Chemistry ...

LAST 30 PRESS RELEASES:

How stepping into nature affects the brain

Study: Cancer’s clues in the bloodstream reveal the role androgen receptor alterations play in metastatic prostate cancer

The Lancet: New weight loss pill leads to greater blood sugar control and weight loss for people with diabetes than current oral GLP-1, phase 3 trial finds