PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

A third of women experience migraines associated with menstruation, most commonly when premenopausal

2024-04-12
(Press-News.org) WASHINGTON (April 12, 2024) – A third of the nearly 20 million women who participated in a national health survey report migraines during menstruation, and of them, 11.8 million, or 52.5%, were premenopausal. The analysis was conducted by researchers at Georgetown University Medical Center and Pfizer, Inc., which makes a migraine medication. 

Because of  the underuse of medications to help treat or prevent menstrual migraines, investigators wanted to understand how common menstrual migraines were and which groups of women could most benefit from potential therapies. The study will be presented April 16, at the American Academy of Neurology 2024 Annual Meeting in Denver.

“The first step in helping a woman with menstrual migraine is making a diagnosis; the second part is prescribing a treatment; and the third part is finding treatments patients are satisfied with and remain on to reduce disability and improve quality of life,” says the study author, Jessica Ailani, MD, professor of clinical neurology at Georgetown University School of Medicine and director of the MedStar Georgetown Headache Center at Medstar Georgetown University Hospital.

The researchers used the 2021 U.S. National Health and Wellness Survey, conducted by the National Center for Health Statistics, to analyze responses from women who reported their current migraine treatments, frequency and disabilities via the Migraine Disability Assessment Test (MIDAS), a five-question survey. A migraine headache can cause severe throbbing pain or a pulsing sensation, usually on one side of the head. It's often accompanied by nausea, vomiting, and extreme sensitivity to light and sound.

“Discrepancies in the incidence of who gets migraine attacks associated with menses is likely due to premenopausal women having more regular menstrual cycles and thus more menstrual-related migraines,” says Ailani. “Additionally, as women move into their 40's and become peri-menopausal, there tends to be a greater shift through the month in hormone levels also leading to frequent migraine attacks.”

The survey found that for all women during their menstrual periods, migraine attacks occurred as frequently as 4.5 times and that monthly only migraine headaches lasted 8.4 days, on average; 56.2 % of women had moderate-to-severe migraine-specific disabilities that ranked highest on the MIDAS scale.

When looking at treatments women in the survey used to help control their migraine symptoms, 42.4% used over-the-counter medications while 48.6% used prescription medications. Of the 63.9 % of women who used migraine treatments for acute symptoms, the most commonly used were triptans, a class of drugs developed in the 1990s to quiet overactive nerves associated with migraines and cluster headaches.

Sara’s story

Sara, a 38 year old mother of two, says her migraines are predictably and consistently worse during her period.

“It definitely disrupts my ability to go about my normal activities including at work,” Sara says. “I’m pretty lucky that I’m generally responsive to prescription medication, but I often still have to lie down for an hour or so while the medicine kicks in.”

Sara is being treated preventatively for migraines with Botox.  She says over the past couple of months, she’s had a couple of migraines outside of when she gets her period, but that the headaches are definitely worse during menstruation.

“While I had my last period, I had a migraine every day for a week,” Sara says. “It’s starkly different [during menstruation].”

Prevention Possibilities

Non-steroidal anti-inflammatory drugs (NSAIDs), such as naproxen or ibuprofen, are sometimes used as preventive medications for women with regular menstrual periods. In this study, 21.1% of women reported use of any migraine prevention medications or therapies.

“Preventive treatments are used less frequently than acute treatment for migraine,” Alaini said.
“In my opinion, this is because preventive therapy is a long-term commitment by both a woman and her clinician to improving the disease process. Migraine is a life-long brain disease without a cure, and the goal of preventive therapy is to reduce disease burden and improve quality of life.  Unfortunately, newer disease-specific treatments are costly, so generic older treatments are often used and come with greater side effects.”

Next Steps

The researcher’s next steps involve looking at larger databases to see if they can mimic findings on a global scale. They want to determine if women with menstrual-related migraine are frequently turning to non-migraine treatments as was seen in around 53% of their current study group.

“As a headache specialist in the U.S., I know I can do better for women in my clinic, but what can be done for the millions of women who don't get into a headache clinic? That is our true next step,” says Ailani. “If you have migraines related to your menstrual cycle, discuss this with your gynecologist or neurologist. There are treatments that can help and if the first treatment tried does not work, do not give up.”

###

In addition to Ailani, co-authors include Joshua Brown, Motomori Lewis, Aaron Jenkins, Jessica Cirillo, Karin Hygge Blakeman, Jiyue Yang, Lucy Abraham from Pfizer, Inc, New York.

This work was supported by Pfizer.

Ailani reports receiving personal compensation for serving as a consultant for Pfizer. Additional disclosures from her and her co-authors can found be on the AAN website.

END



ELSE PRESS RELEASES FROM THIS DATE:

MD Anderson Research Highlights for April 12, 2024

2024-04-12
HOUSTON ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson offer insights into a combination strategy to improve immunotherapy responses, promising trial results for patients with tumors harboring BRAF mutations, a maintenance strategy for patients with acute myeloid leukemia following chemotherapy, a strategy ...

Soft Robotics appoints new Deputy Editor-in-Chief, Barbara Mazzolai, PhD

Soft Robotics appoints new Deputy Editor-in-Chief, Barbara Mazzolai, PhD
2024-04-12
Mary Ann Liebert, Inc., is pleased that Barbara Mazzolai, PhD, has been appointed the new Deputy Editor-in-Chief of the bimonthly journal Soft Robotics. Dr. Mazzolai joins Barry Trimmer, PhD, as part of the executive editorial team for the journal. Soft Robotics is the leading robotics journal devoted to the emerging technologies and developments of soft and deformable robots.  The journal’s coverage includes flexible electronics, materials science, computer science, and biomechanics. The journal breaks new ground as the first to answer the urgent need for research on robotic technology that can safely ...

Wiley releases Mass Spectra of Designer Drugs 2024 to accelerate forensics analysis of fentanyls, cannabinoids, and more

2024-04-12
Wiley, one of the world’s largest publishers and a global leader in research and learning, today announced the 2024 release of the Mass Spectra of Designer Drugs. This indispensable spectral database serves as a cornerstone for forensic laboratories worldwide, enabling swift identification of illicit substances. Sourced from both legal and underground literature, it provides access to the latest novel psychoactive substances (NPS) like variants of fentanyl, xylazine, various opioids, synthetic cannabinoids, and more. This annually refreshed database provides access to 35,094 mass spectra representing 26,712 unique ...

Freestanding emergency departments are popular, but do they function as intended?

2024-04-12
By Ann Kellett, Texas A&M University School of Public Health Freestanding emergency departments (EDs) — either satellite branches of hospitals or independently operated facilities — have popped up across the country. Texas has the most, with 338 freestanding EDs as of May 2023, and these facilities handle nearly one quarter of all emergency department visits in the state. Now, a new study from the Texas A&M University School of Public Health is the first to compare the characteristics of visits to freestanding EDs with visits to traditional hospital-based ...

University of Cincinnati experts present at national neurology conference

University of Cincinnati experts present at national neurology conference
2024-04-12
University of Cincinnati researchers will present abstracts at the American Academy of Neurology annual meeting 2024, April 13-18 in Denver, Colorado. Two-component treatment leads to improvement for patients Late-onset Pompe disease (LOPD) is a rare, inherited genetic disease caused by the accumulation of glycogen, the body’s stored form of glucose, in muscles and other organs. Left untreated, the muscle weakness it causes can lead to the loss of the ability to walk and breathing impairment. A research team led by UC’s ...

Bonobos are more aggressive than previously thought

Bonobos are more aggressive than previously thought
2024-04-12
Chimpanzees and bonobos are often thought to reflect two different sides of human nature—the conflict-ready chimpanzee versus the peaceful bonobo—but a new study publishing April 12 in the journal Current Biology shows that, within their own communities, male bonobos are more frequently aggressive than male chimpanzees. For both species, more aggressive males had more mating opportunities. “Chimpanzees and bonobos use aggression in different ways for specific reasons,” says anthropologist and lead author Maud Mouginot of Boston University. “The idea is not to invalidate the ...

How seaweed became multicellular

2024-04-12
A deep dive into macroalgae genetics has uncovered the genetic underpinnings that enabled macroalgae, or “seaweed,” to evolve multicellularity. Three lineages of macroalgae developed multicellularity independently and during very different time periods by acquiring genes that enable cell adhesion, extracellular matrix formation, and cell differentiation, researchers report April 12 in the journal Molecular Plant. Surprisingly, many of these multicellular-enabling genes had viral origins. The study, which increased the total number of sequenced macroalgal genomes from 14 to 124, is the first to investigate ...

Melanomas resist drugs by ‘breaking’ genes

Melanomas resist drugs by ‘breaking’ genes
2024-04-12
Melanoma is the deadliest form of skin cancer. With global incidence rates rising, new, more effective treatments are necessary to alleviate the health burden of the disease. Important advances in recent years include doctors using genetic tests to look for specific mutations they can target for more personalised, effective treatment. Around 1 in 2 melanoma patients will have mutations in the BRAF gene. This gene normally makes a protein which helps control cell growth, but mutations can cause the cells to grow and divide uncontrollably instead, happening in many different types of cancer including ...

Africa’s iconic flamingos threatened by rising lake levels, study shows

2024-04-12
It is one of the world’s most spectacular sights – huge flocks or “flamboyances” of flamingos around East Africa’s lakes – as seen in the film Out of Africa or David Attenborough’s A Perfect Planet. But new research led by King’s College London has revealed how the lesser flamingo is at danger of being flushed out of its historic feeding grounds, with serious consequences for the future of the species. For the first time satellite earth observation data has been used to study all the key flamingo feeding lakes in Ethiopia, Kenya and Tanzania over two decades and it identified how rising ...

Vaccination timeliness among US children ages 0-19 months

2024-04-12
About The Study: In this study of National Immunization Survey–Child data, improvements in vaccination timeliness were observed from the 2011 to the 2021 survey. However, widening disparities by socioeconomic indicators signal that increased efforts to facilitate timely vaccination among children in lower-income families are needed.  Authors: Sophia R. Newcomer, Ph.D., M.P.H., of the University of Montana, Missoula, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this ...

LAST 30 PRESS RELEASES:

Scientists uncover a multibillion-year epic written into the chemistry of life

Monitoring diseases through sweat becomes accessible to everyone

Mathematical model driven evolutionary therapy dosing exploiting cancer cell plasticity

Biodiversity in the margins: Merging farmlands affects natural pest control

1 in 8 pregnant people have a disability, but significant gaps exist in the provision of accessible care

Statins associated with decreased risk for CVD and death, even in very old adults

Climate change is moving tree populations away from the soil fungi that sustain them

Secrets of sargassum: Scientists advance knowledge of seaweed causing chaos in the Caribbean and West Africa

Bioinformatics approach could help optimize soldiers’ training for improved readiness and recovery

Earth scientists describe a new kind of volcanic eruption

Warmer wetter climate predicted to bring societal and ecological impact to the Tibetan Plateau

Feeding infants peanut products protects against allergy into adolescence

Who will like beetle skewers? What Europeans think about alternative protein food

ETRI wins ‘iF Design Award’ for mobile collaborative robot

Combating carbon footprint: novel reactor system converts carbon dioxide into usable fuel

Investigating the origin of circatidal rhythms in freshwater snails

Altering cellular interactions around amyloid plaques may offer novel Alzheimer’s treatment strategies

Brain damage reveals part of the brain necessary for helping others

Surprising properties of elastic turbulence discovered

Study assesses cancer-related care at US hospitals predominantly serving minority populations compared with non-minority serving hospitals

First in-human investigator-initiated clinical trial to launch for refractory prostate cancer patients: Novel alpha therapy targets prostate-specific membrane antigen

Will generative AI change the way universities communicate?

Artificial Intelligence could help cure loneliness, says expert

Echidnapus identified from an ‘Age of Monotremes’

Semaglutide may protect kidney function in individuals with overweight or obesity and cardiovascular disease

New technique detects novel biomarkers for kidney diseases with nephrotic syndrome

Political elites take advantage of anti-partisan protests to disrupt politics

Tiny target discovered on RNA to short-circuit inflammation, UC Santa Cruz researchers find

Charge your laptop in a minute? Supercapacitors can help; new research offers clues

Scientists discover CO2 and CO ices in outskirts of solar system

[Press-News.org] A third of women experience migraines associated with menstruation, most commonly when premenopausal