The role of three-dimensional power doppler for detecting ovarian cancer in adnexal masses
2024-05-22
(Press-News.org) Background and Aims
Three-dimensional power Doppler (3DPD) ultrasound has been used for assessing adnexal masses, and in this study, we aimed to perform a meta-analysis to evaluate its role in the differential diagnosis of adnexal masses.
Methods
A search for primary studies assessing the diagnostic performance of 3DPD in discriminating benign from malignant masses carried out between January 1990 and May 2023 was performed in Medline (PubMed), Scopus, and Web of Science databases with study quality evaluated using QUADAS-2.
Results
We identified 404 citations. Ultimately, 18 studies comprising 2,975 women were included, and the mean prevalence of malignant lesions was 37%. In most cases, the quality of studies was moderate. Overall, pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of 3DPD vascular tree assessment for studies including any type of mass were 77% (95% confidence interval [CI] = 52%–91%), 80% (95% CI = 37%–97%), 3.9 (95% CI = 0.7–20.9), and 0.29 (95% CI = 0.10–0.81), respectively. Heterogeneity was high for both sensitivity and specificity. Pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of 3DPD vascular tree assessment for studies including only “complex” or “suspicious” adnexal masses were 90% (95% CI = 82%–94%), 88% (95% CI = 74%–95%), 7.3 (95% CI = 3.2–16.4), and 0.12 (95% CI = 0.06–0.22), respectively. Heterogeneity was moderate for both sensitivity and specificity. We could not perform quantitative synthesis for studies estimating 3D vascular indexes.
Conclusions
In conclusion, in this meta-analysis, we have observed that 3DPD using the assessment of the tumor vascular tree featured a good diagnostic performance in discriminating between benign and malignant adnexal masses, and the diagnostic performance is better when this technique is used in “complex” or “suspicious” adnexal masses. Despite this, 3DPD does not add diagnostic information to current 2D ultrasound-based approaches for the differential diagnosis of adnexal masses. However, further major research is needed particularly to determine for which adnexal masses it could be useful and what criteria should be used.
Full text
https://www.xiahepublishing.com/2996-3427/OnA-2023-00034
The study was recently published in the Oncology Advances.
Oncology Advances is dedicated to improving the diagnosis and treatment of human malignancies, advancing the understanding of molecular mechanisms underlying oncogenesis, and promoting translation from bench to bedside of oncological sciences. The aim of Oncology Advances is to publish peer-reviewed, high-quality articles in all aspects of translational and clinical studies on human cancers, as well as cutting-edge preclinical and clinical research of novel cancer therapies.
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[Press-News.org] The role of three-dimensional power doppler for detecting ovarian cancer in adnexal masses
