(Press-News.org) According to a recent study published in Chemical Engineering Journal, a collaborative research team led by Professor WANG Hui from High Magnetic Field Laboratory, Hefei Institutes of Science of Chinese Academy of Sciences developed magnetite nanozyme (MNZs) with dual enzymatic activities through structural engineering, and proved its structure-dependent behavior in the process of tumor treatment.
MNZs, as a substitute for natural enzymes, has been widely studied in the field of tumor catalytic therapy. However, the catalytic efficiency of traditional MNZs in tumor microenvironment (TME) is often limited, which is mainly due to the low production rate of hydroxyl radical (·OH).
In this study, the team developed MNZs with dual enzyme activity using solvothermal method.
"We prepared MNZs with three different shapes: flakes, ellipses and spheres," said Prof. WANG hui, "and this allowed us to check out how the shapes affect the treatment and reveal the potential mechanism both in vitro and in vivo."
The novel MNZs exhibit two important functions: They imitate glutathione, which is an antioxidant in cells. This helps to reduce the consumption of harmful hydroxyl radicals; and they act as peroxidases, breaking down hydrogen peroxide and generating highly toxic hydroxyl radicals. This self-cascade reaction disrupts the balance of reactive oxygen species in cells, enhancing the therapeutic effect on tumors.
This progress not only provides a new strategy for tumor catalytic therapy, but also opens up possibilities for the future application of nano-materials in the biomedical field, according to the team.
END
Structural engineering unlocks potent tumor treatment with dual-function magnetite nanozymes
2024-05-29
ELSE PRESS RELEASES FROM THIS DATE:
Polymeric films protect anodes from sulfide solid electrolytes!
2024-05-29
People have various relationships in society including those with family, friends, and coworkers. While these relationships play a significant role in our lives, it's crucial to maintain a healthy distance as being too close can lead to intense emotions or conflicts. Interestingly, a recent study in the field of chemistry demonstrates that maintaining such distance can enhance battery performance in electric vehicles.
In this research, Professor Soojin Park, Dr. Sungjin Cho and Youngjin Song, a PhD student, from the Department of Chemistry at Pohang University of Science and Technology (POSTECH) in collaboration with the team of Professor Sung Gap Im ...
Altering cancer treatment dosing could reduce climate impact, study finds
2024-05-29
May 28, 2024
For more information, contact:
Nicole Fawcett, nfawcett@umich.edu
EMBARGOED for release at 6:30 p.m. ET May 28, 2024
Altering cancer treatment dosing could reduce climate impact, study finds
Model estimates potential to reduce greenhouse gas emissions by delivering treatment every 6 weeks
ANN ARBOR, Michigan — Changing how often a popular cancer therapy is delivered would reduce greenhouse gas emissions and improve environmental impact without decreasing cancer survival, according to a new analysis from researchers at the University of Michigan Health Rogel ...
The secret sex life of coral revealed
2024-05-29
Corals play an essential role in ocean ecosystems, and like many organisms, they are under threat from climate change and other human activities. To better protect coral, it’s first necessary to understand them, in particular their reproductive life cycle, which only happens once a year. For the first time, researchers have produced a model for coral spawning, based on various environmental factors. They achieved this by tapping an often overlooked source of aquatic knowledge, an aquarium.
Given their branching shapes or waving tendrils, you would be ...
New deep learning model is ‘game changer’ for measuring embryo development
2024-05-29
Research led by the University of Plymouth has shown that a new deep learning AI model can identify what happens and when during embryonic development, from video.
Published today (Wednesday 29 May) in the Journal of Experimental Biology, the study highlights how the model, known as Dev-ResNet, can identify the occurrence of key functional developmental events in pond snails, including heart function, crawling, hatching and even death.
A key innovation in this study is the use of a 3D model that uses changes occurring between frames of the video, and enables the AI to learn from these features, as opposed to the more traditional use of still images.
The ...
Smarter foragers do not forage smarter
2024-05-29
Primates, including humans, have larger brains than most other mammals, but why? Scientists searching for the answer have long followed a trail pointing to diet—specifically fruit—as the reason for why primates evolved larger brains. A team from the Max Planck Institute of Animal Behavior and the Smithsonian Institute of Tropical Research tested this idea for the first time—finding that the fruit-diet theory might be out of juice. The researchers used drone imaging, GPS tracking, and fine-scale behavioral analyses to test how four species of fruit-eating mammals solved the same natural foraging puzzle in a Panamanian rainforest. They ...
A unified account of Darwinism’s varieties
2024-05-29
A new paper published in The Quarterly Review of Biology examines the question of what Darwinism is and how its nonscientific uses relate to the scientific theory of evolution.
Charles Darwin published On the Origin of Species in 1859 as a work in biology. However, in the past century and a half, Darwin’s ideas have impacted a broad range of domains and stimulated scientists and scholars to advance "evolutionary approaches" in domains as diverse as economics, engineering, psychology, and history. The ideas have been used (and abused) to undermine religiously inspired ideas about the origin of humans and their status concerning other species, ...
Marketers can manage 'feature creep'
2024-05-29
AUSTIN, Texas — Wifi-enabled washing machines. Voice-controlled microwaves. App-enabled TVs, vacuum cleaners, and even window blinds you can control from the comfort of your couch.
Many of the technological features now included in everyday products are useful and accessible. But research has shown that having too many can overwhelm potential buyers, making them less likely to make a purchase.
In new research, Wayne Hoyer, marketing professor and James L. Bayless/William S. Farrish Fund Chair for Free Enterprise at Texas McCombs, digs into the phenomenon of “feature creep” and its impact on consumer sentiment. ...
Intermittent fasting shows promise in improving gut health, weight management
2024-05-29
A new study by researchers from Arizona State University and their colleagues highlights a dietary strategy for significant health improvement and weight management.
Participants following an intermittent fasting and protein-pacing regimen, which involves evenly spaced protein intake throughout the day, saw better gut health, weight loss and metabolic responses. These benefits were notably greater than those seen with simple calorie restriction.
The findings, reported today in the journal Nature ...
Scientists identify gene that could lead to resilient ‘pixie’ corn
2024-05-29
AMES, Iowa – A widely found gene in plants has been newly identified as a key transporter of a hormone that influences the size of corn. The discovery offers plant breeders a new tool to develop desirable dwarf varieties that could enhance the crop’s resilience and profitability.
A team of scientists led by Iowa State University spent years working to pinpoint the functions of the gene ZmPILS6. Now, they have been able to characterize it as an important driver of plant size and architecture, a carrier for an auxin hormone that helps govern growth in roots below ground and shoots, or stalks, above ground. Their findings were published in the Proceedings ...
Utilizing medical assistants to manage patient portal messages shown to support practice and physician efficiency
2024-05-28
Many primary care clinicians directly receive messages from patients via electronic health records’ portal inboxes. The COVID-19 pandemic saw a rapid uptick in this trend. Data suggests that this additional work is linked to clinician burnout. Penn Family Care, a primary care group at Penn Medicine, instead routed incoming messages to certified medical assistants who had been taught how to distribute each message to the most appropriate physician. There was a 40% decrease in the number of messages going directly to primary care physicians, and both practice and clinician efficiency showed improvement after adopting this team-based care model.
Utilizing Medical Assistants ...