PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Trial reveals benefits of ‘stepped’ palliative care for patients with advanced lung cancer

Findings suggest that this is an effective and more scalable means to deliver palliative care to improve patients’ quality of life

2024-06-02
(Press-News.org) BOSTON – A new study led by investigators from Mass General Cancer Center, a founding member of the Mass General Brigham healthcare system, reveals the effectiveness of more scalable ways of delivering palliative care to patients with advanced lung cancer. The findings were highlighted at the American Society of Clinical Oncology’s annual meeting and are published in JAMA.

The study, led by Jennifer S. Temel, MD of the Mass General Cancer Center, assessed the effectiveness of stepped palliative care, in which all patients receive palliative care for their condition, but with a minimum of required contact with a specialty-trained clinician. More intensive treatment is reserved for those who do not benefit sufficiently from the less intensive care.

This randomized trial included 507 patients with advanced lung cancer who received either early standard palliative care or stepped palliative care.

Studies show that early palliative care, integrated with oncology care from the time of diagnosis of advanced cancer, improves patient and caregiver outcomes. However, this care model has not been widely implemented for two main reasons: the shortage of palliative care clinicians nationwide and challenges in providing palliative care visits throughout the course of cancer treatment, especially as novel therapeutics prolong survival.

Investigators in this study found that stepped palliative care, with visits occurring only at key points in patients’ cancer trajectories and using a decrease in quality of life to trigger more visits, resulted in fewer palliative care visits without diminishing the benefits for patients’ quality of life.

“To our knowledge, this is the first randomized trial to establish the non-inferiority of a palliative care strategy that’s tailored to a patient’s needs by triggering more intensive palliative care services based on patient-reported quality of life, compared with resource-intensive early palliative care,” said Temel, who co-directs the Cancer Outcomes Research and Education Program and is the clinical director of Thoracic Oncology at Massachusetts General Hospital.

 

Disclosures: Disclosure forms provided by the authors are available with the full text of this article at https://jamanetwork.com

Funding: Research support provided by the National Cancer Institute.

Paper cited: Temel JS et al. “Stepped Palliative Care for Patients with Advanced Lung Cancer: A Multi-site Randomized Clinical Trial.” JAMA DOI: 10.1001/jama.2024.10398

###

About Massachusetts General Hospital

Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The Mass General Research Institute conducts the largest hospital-based research program in the nation, with annual research operations of more than $1 billion and comprises more than 9,500 researchers working across more than 30 institutes, centers and departments. MGH is a founding member of the Mass General Brigham healthcare system.

 

END



ELSE PRESS RELEASES FROM THIS DATE:

Socioeconomic status influences genetic risk for many complex diseases

2024-06-02
Berlin, Germany:  Differences in socioeconomic status (SES) are known to be linked to differences in the risk of developing disease. While people with lower SES are more likely to develop complex diseases such as diabetes and cardiovascular disease, those with a higher SES are at increased risk of developing certain types of cancer. Using biobank and national register data, researchers from Finland have now found that people with lower SES (educational achievement and occupation) have a greater genetic susceptibility to develop many other complex diseases such as rheumatoid arthritis, lung cancer, depression, and alcohol ...

ASCO: New ‘Armored’ CAR produces significant responses in patients whose cancers don't respond to current CAR T cell therapies

2024-06-01
CHICAGO – While CAR T cell therapy has revolutionized treatment for many blood cancers, including non-Hodgkin lymphoma (NHL), many patients who receive CAR T cell therapy do not experience a long-term remission. For those whose cancers return or become resistant after CAR T cell therapy, the prognosis is poor, with few options left. A new “armored” form of CAR T cell therapy, developed by Carl June, MD, the Richard W. Vague Professor in Immunotherapy in the Perelman School of Medicine at the University ...

People with well-controlled, long-duration type 1 diabetes may still face high risk of heart disease

2024-06-01
BOSTON—People who have had type 1 diabetes for more than 50 years without kidney complications may still be at substantial risk for heart disease, despite excellent control of blood pressure, cholesterol and blood sugar levels, according to a study presented Saturday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass. Heart disease is a major cause of death in people with type 1 diabetes, especially in those who develop kidney complications from diabetes. “As people with type 1 diabetes live longer due to improved medical care, a substantial proportion of these patients survive without kidney complications, but are still at high risk for heart ...

GLP-1 medications for type 2 diabetes and obesity may lower risk of acute pancreatitis

2024-06-01
BOSTON—Medications for type 2 diabetes and obesity known as GLP-1 receptor agonists may lower the risk of acute pancreatitis recurrence in people with obesity and those with type 2 diabetes, according to a study presented Saturday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass. Doctors have been cautious about prescribing these medications in patients with a history of pancreatitis due to the potential risk of worsening the condition – a warning that is included in prescribing information, said lead researcher Mahmoud Nassar, M.D., Ph.D., Department of Medicine ...

Anti-obesity medication tirzepatide remains effective even for those with diabetes and other complications

2024-06-01
BOSTON—Having medical conditions linked to obesity does not impact the total weight loss achieved with the anti-obesity medication tirzepatide, according to an industry-supported study being presented Saturday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.  Obesity causes or worsens over 200 diseases. It has been widely believed that when patients suffer multiple medical problems, they are not able to lose as much weight as those without medical issues. The new study, funded by tirzepatide maker Eli Lilly Inc., was designed to see if having more obesity-associated ...

Risk for heart attack and stroke increases in people with obesity for a decade or more

2024-06-01
BOSTON—People under age 50 have a greater risk for heart attack or stroke if they’ve lived with obesity for 10 years, according to industry-sponsored research being presented Saturday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass. “It is well established that people who have excess weight at any point in time have a greater risk of heart attacks and strokes. What was not known was whether it matters for how long someone has been exposed to excess weight,” said Alexander Turchin, M.D., M.S., Director of Quality at the Division of Endocrinology at Brigham & Women’s ...

Asian patients more likely to develop type 2 diabetes 1 year after prediabetes diagnosis compared to white and Black patients

2024-06-01
BOSTON—One year after a prediabetes diagnosis, Asians were more likely to develop diabetes mellitus whereas Black patients were more likely to remain in prediabetes range, highlighting racial disparities in diabetes prevention, according to data presented at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass. “Every year a small proportion of patients with prediabetes will progress to diabetes mellitus with some proportion of patients reverting to normal glucose levels,” said Ewelina Niedzialkowska, M.D., an internal medicine resident at Corewell Health William Beaumont University Hospital, in Royal Oak, Mich. “While diet, lifestyle ...

Synthetic estrogen associated with increased anxiety-like behaviors in a rat model

2024-06-01
BOSTON—The type of estrogen in hormonal birth control may influence anxiety-like behaviors, according to data presented by Abigail Hegwood, M.S., from the Prakapenka Lab at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass. “It is plausible that estrogen type is a key player in mood or cognitive related side effects of hormone-based contraceptive use,” said Alesia Prakapenka, Ph.D., an assistant professor in the Biomedical Sciences program at Midwestern University in Downers Grove, Ill. According to the CDC, 12.6% of women in the United States between the ages of 15 and 49 reported using oral contraceptives from ...

Revolutionizing robotics: A breakthrough in soft actuator technology

Revolutionizing robotics: A breakthrough in soft actuator technology
2024-06-01
In an era where robotics are increasingly becoming a part of everyday life, a significant breakthrough has been made by a team of researchers at Zhe jiang University, China. Their latest creation, a wrist-inspired soft actuator capable of bidirectional torsion, promises to transform the landscape of soft robotics. The innovative design of this actuator, described in detail in the journal Cyborg Bionic Systems, is inspired by the human wrist's ability to perform complex movements. Unlike traditional robotic mechanisms that rely on rigid components, this soft actuator utilizes a magneto-pneumatic hybrid system combined with a Kresling origami structure. This design allows for an astonishing ...

Huazhong University unveils breakthrough in rapid topology identification for complex networks

Huazhong University unveils breakthrough in rapid topology identification for complex networks
2024-06-01
Researchers from Huazhong University of Science and Technology, in collaboration with the Donders Institute for Brain, Cognition and Behavior at Radboud University, have developed a revolutionary method for the rapid identification of network topologies. Their new approach, detailed in a recent publication in Cyborg Bionic Systems, significantly accelerates the process of understanding complex dynamical networks, which are crucial in numerous applications ranging from power grids to transportation systems. The innovative method, named Finite-Time Topology Identification of Delayed Complex Dynamical Networks (FT-TIDCN), leverages finite-time stability ...

LAST 30 PRESS RELEASES:

Scientists discover “bacterial constipation,” a new disease caused by gut-drying bacteria

DGIST identifies “magic blueprint” for converting carbon dioxide into resources through atom-level catalyst design

COVID-19 vaccination during pregnancy may help prevent preeclampsia

Menopausal hormone therapy not linked to increased risk of death

Chronic shortage of family doctors in England, reveals BMJ analysis

Booster jabs reduce the risks of COVID-19 deaths, study finds

Screening increases survival rate for stage IV breast cancer by 60%

ACC announces inaugural fellow for the Thad and Gerry Waites Rural Cardiovascular Research Fellowship

University of Oklahoma researchers develop durable hybrid materials for faster radiation detection

Medicaid disenrollment spikes at age 19, study finds

Turning agricultural waste into advanced materials: Review highlights how torrefaction could power a sustainable carbon future

New study warns emerging pollutants in livestock and aquaculture waste may threaten ecosystems and public health

Integrated rice–aquatic farming systems may hold the key to smarter nitrogen use and lower agricultural emissions

Hope for global banana farming in genetic discovery

Mirror image pheromones help beetles swipe right

Prenatal lead exposure related to worse cognitive function in adults

Research alert: Understanding substance use across the full spectrum of sexual identity

Pekingese, Shih Tzu and Staffordshire Bull Terrier among twelve dog breeds at risk of serious breathing condition

Selected dog breeds with most breathing trouble identified in new study

Interplay of class and gender may influence social judgments differently between cultures

Pollen counts can be predicted by machine learning models using meteorological data with more than 80% accuracy even a week ahead, for both grass and birch tree pollen, which could be key in effective

Rewriting our understanding of early hominin dispersal to Eurasia

Rising simultaneous wildfire risk compromises international firefighting efforts

Honey bee "dance floors" can be accurately located with a new method, mapping where in the hive forager bees perform waggle dances to signal the location of pollen and nectar for their nestmates

Exercise and nutritional drinks can reduce the need for care in dementia

Michelson Medical Research Foundation awards $750,000 to rising immunology leaders

SfN announces Early Career Policy Ambassadors Class of 2026

Spiritual practices strongly associated with reduced risk for hazardous alcohol and drug use

Novel vaccine protects against C. diff disease and recurrence

An “electrical” circadian clock balances growth between shoots and roots

[Press-News.org] Trial reveals benefits of ‘stepped’ palliative care for patients with advanced lung cancer
Findings suggest that this is an effective and more scalable means to deliver palliative care to improve patients’ quality of life