(Press-News.org) About The Study: Among families from North America with germline CDH1 P/LP variants, the cumulative risk of gastric cancer was 7% to 10%, which was lower than previously described, and the cumulative risk of breast cancer among female carriers was 37%, which was similar to prior estimates. These findings inform current management of individuals with germline CDH1 variants.
Quote from corresponding author Jeremy L. Davis, M.D.:
“We showed that the lifetime risk of cancer, specifically stomach cancer, in people born with CDH1 gene mutations is lower than we previously thought. This is very important to patients because for over 20 years we have recommended prophylactic stomach removal to eliminate the risk of hereditary gastric cancer. Complete stomach removal is a major operation, and life without a stomach has significant, long-lasting consequences.
“We believe these results will help many people save their stomachs. It is important to note that this research was made possible by a commitment to studying a rare disease and by sharing data across institutions.”
Contact information for Jeremy L. Davis, M.D.: email jeremy.davis@nih.gov.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jama.2024.10852)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Media advisory: This study is being presented at the International Gastric Cancer Linkage Consortium.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.10852?guestAccessKey=9c9de2ae-3560-45c3-a7af-85de311bebc2&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=061424
END
Germline CDH1 variants and lifetime cancer risk
JAMA
2024-06-14
ELSE PRESS RELEASES FROM THIS DATE:
Dapagliflozin for critically ill patients with acute organ dysfunction
2024-06-14
About The Study: The addition of dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, to standard care for critically ill patients and acute organ dysfunction did not improve clinical outcomes; however, confidence intervals were wide and could not exclude relevant benefits or harms for dapagliflozin.
Corresponding Author: To contact the corresponding author, Fernando G. Zampieri, M.D., Ph.D., email fernando.zampieri@einstein.br.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jama.2024.10510)
Editor’s ...
RECLARIT: Self-management in practice
2024-06-14
Disease activity, structural damage, and progression all impact the lives of people with rheumatoid arthritis (RA), and can cause psychosocial distress. While inhibition of inflammation and structural changes have improved significantly following advances in pharmacological treatment in recent dates, the observed impact of these disease-modifying antirheumatic drugs (DMARD) on key psychosocial outcomes is limited.3 An important feature within the EULAR recommendations on self-management in people with inflammatory arthritis is that digital healthcare is tagged as being essential in supporting and optimising self-management2. . Thus healthcare professionals need to be aware ...
Survey now open: EULAR invites patients across Europe to participate in groundbreaking study on rheumatic and musculoskeletal diseases
2024-06-14
People living with RMDs can now fill out the survey online, sharing their experiences to help build a comprehensive understanding of their disease's impact. The data collected will be invaluable for researchers, healthcare professionals, and patients themselves, providing insights into the burden of RMDs and identifying areas for improvement in care.
EULAR is committed to inclusivity and accessibility; the survey will soon be available in multiple European languages in addition to English. This ensures that a diverse range of patients can contribute their perspectives, enhancing the richness and applicability of the data.
Participants will answer a baseline survey ...
EULAR launches the EULAR Network of Trial Centres (ENTRI), a unique initiative transforming the way clinical trials are delivered
2024-06-14
ENTRI aims to:
Create a network of clinical trial centres, accessible to all investigators and sponsors from both public and private sectors.
Build capacity and training in clinical trials and experimental medicine studies.
Provide RMD-related clinical trials toolkits underpinned by best practice.
By facilitating the delivery of incisive research trial studies, ENTRI helps generate the evidence required to implement changes in clinical practice that are meaningful and beneficial to patients. ENTRI members will be invited to participate in cutting-edge projects sponsored by both public and private sectors. Facilitating faster translation of results into ...
Could interferon signature aid in the diagnosis and stratification of pediatric Sjögren’s?
2024-06-14
Sjögren’s disease is rare in children, and presenting symptoms differ from those seen in adults. For example, paediatric patients present less often with sicca complaints, and more frequently with parotid gland swelling and fever.1 This new work aimed to identify potentially dysregulated molecular pathways in children with Sjögren’s disease by comparing the transcriptome of peripheral blood cells between 18 patients and 23 controls – using differential gene expression and pathway analysis. In addition to whole transcriptome analysis of blood samples, expression of interferon-stimulated genes (ISG) was measured in paired ...
Putting rheumatic and musculoskeletal diseases (RMDs) at the forefront of the next European Union healthcare agenda
2024-06-14
Why are RMDs an issue for Europe?
RMDs, often dubbed 'the invisible diseases', affect approximately 120 million Europeans, constituting one in five individuals across the continent. Despite their prevalence, there remains a significant lack of awareness among policymakers and the general public, leading to their frequent neglect in political and financial agendas. However, the impact of RMDs is far-reaching, contributing to physical disability, chronic health conditions, and substantial economic burdens, amounting to an estimated 240 billion Euros annually.
Furthermore, RMDs not only pose a direct threat to individual health but also contribute to the ...
Tackling issues in childhood arthritis
2024-06-14
Community awareness that children and young people get arthritis is low.1 This is associated with delays in diagnosis, worse clinical outcomes, and adverse societal factors such as stigma and isolation. Raising awareness of childhood arthritis is crucial in combatting these issues to improve the lives of those living with JIA. An abstract plenary session at the 2024 EULAR congress shared work from Juvenile Arthritis Research – a patient organisation in the UK that is involved in a variety of projects to raise awareness and support JIA patients and their families. These include a variety ...
Predictors for organ damage
2024-06-14
cSLE is a rare multisystem disorder with significant associated morbidity, but evidence-based guidelines are sparse, and as such management is often based on clinical expertise.2 The EULAR/ACR-2019 criteria have shown sensitivity in cSLE patients, which could allow earlier recognition of patients with single or major organ involvement,3 but identifying specific predictors in this vulnerable group is vital for preventing long-lasting damage.
The new work, presented at the 2024 EULAR congress, aimed ...
Osteoarthritis: associations and comorbidities
2024-06-14
In the 2023 update of their recommendations for osteoarthritis management, EULAR – The European Alliance of Associations for Rheumatology – recognise osteoarthritis as a severe disease, and one with important implications for both the individual and society.3 However, most people with osteoarthritis do not receive optimal management,4,5 and this represents an important unmet need – especially when considering additional systemic comorbidities. To explore this further, ComOA6 has combined case-control and cohort studies for over 3 million people in primary care in the UK, Netherlands, Sweden, and Spain. The analyses – shared at ...
High-precision measurements challenge our understanding of Cepheids
2024-06-14
“Classical Cepheids” are a type of pulsating star that rhythmically brightens and dims over time. These pulsations help astronomers measure vast distances across space, which makes Cepheids crucial “standard candles” that help us understand the size and scale of our universe.
Despite their importance, studying Cepheids is challenging. Their pulsations and potential interactions with companion stars create complex patterns that are difficult to measure accurately. Different instruments and methods used over the years have led to inconsistent data, ...
LAST 30 PRESS RELEASES:
Duckweed offers promise and caution as nature-based solution for rice paddy pollution
Medical evidence crucial in holding polluters accountable for harming health
Climate change and conflict pose a serious health threat, warn experts
Curb sales of SUVs to reduce harms to health and the environment, say experts
Greenness linked to fewer hospital stays for mental health conditions
Experts warn of wider health impact of tropical cyclones in a warming climate
Transforming UK eye health research by linking national data resources
First global survey highlights challenges faced by young women with advanced breast cancer
Advanced breast cancer patients living longer thanks to improvements in treatment and care
Landmark Global Decade Report reveals breakthroughs in advanced breast cancer but exposes a widening global equity gap
Island reptiles face extinction before they are even studied, warns global review
Universe's expansion 'is now slowing, not speeding up'
Nation topped goal of ‘one million more’ STEM graduates over the past decade
AI can speed antibody design to thwart novel viruses: study
The world’s highest honor in computational physics awarded to Stefano Baroni
Radiotherapy after mastectomy can be avoided, study finds
Donor kidneys perform better after machine perfusion
More than a hangover: Heavy drinking linked to earlier, more severe stroke
Heavy alcohol use linked to risk of brain bleed earlier in life
Study links heart attacks and late-onset epilepsy in older adults
Urban fungi show signs of thermal adaptation
How to identify and prevent fraudulent participants in health research
Parents' attachment style may be linked with risk of parental burnout, especially when associated with difficulty in understanding and identifying their emotions
Abnormal repetitive behaviors in mice are associated with oxidative stress
Double disadvantage hurts more than twice as much
Paradox of rotating turbulence finally tamed with world-class ‘hurricane-in-a-lab’
Brain pathway may fuel both aggression, self-harm
Study: Macrophage “bodyguard” disruptors could change breast cancer treatment by helping to overcome endocrine resistance
New study reveals southern ocean’s winter CO₂ outgassing underestimated by 40%
U of A-led team discovers large ritual constructions by early Mesoamericans
[Press-News.org] Germline CDH1 variants and lifetime cancer riskJAMA