PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Does BMO induced by mechanical stress progress to structural lesions?

Exploring MRI imaging findings in postpartum women

2024-06-14
(Press-News.org) BMO in the sacroiliac joint on MRI is present in up to 84% of people with non-radiographic axSpA – but it is also often seen in a non-inflammatory setting, such as in women after childbirth.1,2 As back pain is common after childbirth, differential diagnosis with axSpA is an important issue in clinical practice.1 In axSpA, active inflammatory lesions are likely to progress to structural lesions over time – particularly fat lesions and erosions. But it is not known whether the same is true for BMO induced by mechanical stress. In June 2024, EULAR – The European Alliance of Associations for Rheumatology – held its annual congress in Vienna, Austria. In a clinical abstract session on imaging aspects of spondyloarthritis, new data were presented on the long-term evolution of postpartum BMO, and the potential development of structural lesions.

 

The researchers used follow-up data from a prospective study examining sacroiliac MRI lesions in healthy women following an uncomplicated vaginal delivery.1 Just over half of the original 35 participants underwent a new MRI of the sacroiliac joint approximately 5 years after initial inclusion. Structural and inflammatory lesions were assessed using a method similar to the Spondyloarthritis Research Consortium of Canada (SPARCC) scoring system. Baseline images were re-evaluated together with the 5-year follow-up data.

 

Overall, low numbers of fat lesions, erosions, and sclerosis were observed at both baseline and in the 5-year MRI images, whereas no ankylosis was accounted for. Fat metaplasia and erosions did not change significantly between baseline and 5-year follow-up. Sclerosis increased in only 3 of the 19 participants, all of whom had BMO after delivery. As expected, there was a significant decrease in BMO from baseline, although 32% of women still had BMO at the 5-year follow-up – half of whom met the ASAS definition of sacroiliitis. Having another delivery during the follow-up period did not seem to affect the presence of BMO at follow-up.

 

These results show that there is no significant development of structural MRI lesions in women 5 years after delivery – but BMO remained prevalent. This supports the hypothesis that transient mechanical stress-induced sacroiliac BMO on MRI does not seem to evolve into structural lesions – at least over the first 5 years.

 

Source

De Meester L, et al. Sacroiliac bone marrow oedema on postpartum MRI does not develop into structural lesions over a 5-year follow-up period. Presented at EULAR 2024; OP0222.

Ann Rheum Dis 2024; DOI: 10.1136/annrheumdis-2024-eular.6091.

 

References

1. Renson T, et al. High prevalence of spondyloarthritis-like MRI lesions in postpartum women: a prospective analysis in relation to maternal, child and birth characteristics. Ann Rheum Dis 2020;79(7):929–34.

 

2. Weber U, et al. Candidate lesion-based criteria for defining a positive sacroiliac joint MRI in two cohorts of patients with axial spondyloarthritis. Ann Rheum Dis 2015;74:1976–82.

 

About EULAR

EULAR is the European umbrella organisation representing scientific societies, health professional associations and organisations for people with rheumatic and musculoskeletal diseases (RMDs). EULAR aims to reduce the impact of RMDs on individuals and society, as well as improve RMD treatments, prevention, and rehabilitation. To this end, EULAR fosters excellence in rheumatology education and research, promotes the translation of research advances into daily care, and advocates for the recognition of the needs of those living with RMDs by EU institutions.

 

Contact

EULAR Communications, communications@eular.org

 

Notes to Editors

EULAR Recommendations

EULAR School of Rheumatology

EULAR Press Releases

 

 

END


ELSE PRESS RELEASES FROM THIS DATE:

Is fish intake linked to JIA?

2024-06-14
In 2019, a Swedish prospective birth cohort study of over 15,000 children showed that consuming fish at least once a week during pregnancy and during the first year of life was associated with up to a 5-fold increased risk of JIA, compared to those with fish consumption less than once a week. This increased risk was primarily attributed to elevated exposure to heavy metals.1 Now, new research shared at the 2024 congress of EULAR – The European Alliance of Associations for Rheumatology – is investigating ...

Unpicking the complexity of systemic sclerosis

2024-06-14
SSc is a connective tissue disease with variable clinical presentation. It may affect the skin, blood vessels, heart, lungs, kidneys, gastrointestinal tract, and musculoskeletal system – and this complexity and diversity makes it challenging to treat.2 This clinical heterogeneity in SSc may be partially explained by SSc-specific antibodies, but a better understanding of additional risk factors and patient stratification is still needed. Three abstracts shared at the 2024 EULAR congress present a selection of new clinical research to enrich knowledge ...

Group tests novel therapeutic strategy to minimize progression of Duchenne muscular dystrophy

2024-06-14
In an animal model of Duchenne muscular dystrophy, Brazilian researchers tested a therapy that combines photobiomodulation using laser light or light-emitting diodes (LEDs) with idebenone, an antioxidant compound investigated for application in neurodegenerative diseases. As reported in an article published in the journal PLOS ONE, the strategy prevented muscle degeneration and improved regenerative capacity in the muscle fibers affected by the disease. Duchenne muscular dystrophy is the most common and most severe form of childhood muscular dystrophy and most often ...

NMDP and CIBMTR share new, promising stem cell transplantation trial data using mismatched, unrelated donors at the 2024 EHA Congress

2024-06-14
MINNEAPOLIS, June 14, 2024 — NMDPSM, a global nonprofit leader in cell therapy, and the CIBMTR® (Center for International Blood and Marrow Transplant Research®) announced interim results from the ACCESS trial as an oral abstract during the European Hematology Association (EHA) Annual Meeting in Madrid, Spain. The study demonstrated that adults with hematologic malignancies who received peripheral blood stem cell (PBSC) transplant from HLA-mismatched unrelated donors (MMUD) followed by post-transplant cyclophosphamide (PTCy) graft-versus-host-disease (GvHD) prophylaxis exhibited a 79% overall survival (OS), the primary ...

Global trial confirms benefit of antacids on bleeding prevention for ventilated patients

Global trial confirms benefit of antacids on bleeding prevention for ventilated patients
2024-06-14
Hamilton, ON (June 14, 2024) – A widely available drug helps prevent upper gastrointestinal bleeding in critically ill adults on a breathing machine, according to the results of a global study and meta-analysis led by researchers at McMaster University. The research, published on June 14, 2024 in The New England Journal of Medicine and NEJM Evidence, investigated the effect of the gastric acid suppressant pantoprazole, which is primarily used to treat heartburn caused by gastroesophageal reflux disease (GERD). Patients ...

Tea crop saviors: Genomic insights into the tea grey geometrid's survival strategy

Tea crop saviors: Genomic insights into the tea grey geometrids survival strategy
2024-06-14
In a breakthrough that could redefine tea crop protection, a new study has shed light on the genetic makeup of the tea grey geometrid, Ectropis grisescens. Through the re-sequencing of 43 genomes, scientists have mapped out the pest's population structure and its remarkable adaptation to tea crops, offering new avenues for managing this agricultural adversary. Amidst the lush tea plantations, a microscopic menace looms—the tea grey geometrid, a pest that can decimate tea yields with its insatiable appetite. The economic and qualitative havoc wreaked by this insect has prompted an urgent call for innovative pest control solutions. However, the genomic secrets ...

Cervical cancer screening rates among rural and urban females

2024-06-14
About The Study: This repeated cross-sectional study found that past-year Papanicolaou testing rates were lower in 2022 than 2019, pointing to a need to increase access to screenings to prevent an uptick in cervical cancer incidence. Rural-vs-urban differences in 2022 indicate a need to specifically target rural females.  Corresponding Author: To contact the corresponding author, Tyrone F. Borders, Ph.D., email ty.borders@uky.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.17094) Editor’s ...

Tiny New Zealand bird delivers a lesson in birdsong evolution

Tiny New Zealand bird delivers a lesson in birdsong evolution
2024-06-14
    Parrots, songbirds, and hummingbirds can learn to make new sounds. No-one knew, but New Zealand’s smallest bird, the rifleman or titipounamu, may have a rudimentary version of the same talent.   University of Auckland research into the bird is part of a rethinking of how and when vocal learning evolved in birds.  Scientists traditionally assumed birds were split into two groups - those which can learn sounds (parrots, songbirds, and hummingbirds) and those which can’t - but the study published in the scientific journal Communications Biology ...

The phase transition of multi-component (TiZrVNb)C ceramics

The phase transition of multi-component (TiZrVNb)C ceramics
2024-06-14
In recent years, high-entropy carbide ceramics have received extensive attention and become another research focus in the high entropy materials field, which are also known as multi-component carbide ceramics. The multi-component carbide ceramics not only inherit the special properties of high-entropy materials brought by complex compositions, but also keep the advantages of transition metal carbide ceramics as a kind of ultra-high temperature ceramics (UHTCs), such as high melting point, high-temperature stability, high Young's modulus, high hardness, and ...

Does endogenous technological change matter in model-based climate change narratives?

2024-06-14
Curbing the confirmed human influence on the climate system and mitigating climate change require profound transformation of global energy system. In this context, modeling technical progress and innovation within Integrated Assessment Models (IAMs) is crucial for providing insights about the consequences of long-term energy system transformation, and capturing the development of several interacting systems and technical evolution process.   A review of Endogenous Technological Change (ETC) written by Hongbo Duan ...

LAST 30 PRESS RELEASES:

Vaccination support program reduces pneumonia-related mortality by 25 percent among the elderly

Over decades, a healthy lifestyle outperforms metformin in preventing onset of Type 2 diabetes

Mental health disorders, malaria, and heart disease most affected by covid pandemic

Green transition will boost UK productivity

Billions voted in 2024, but major new report exposes cracks in global democracy

Researchers find “forever chemicals” impact the developing male brain

Quantum leap in precision sensing across technologies

Upgrading biocrude oil into sustainable aviation fuel using zeolite-supported iron-molybdenum carbide nanocatalysts

For effective science communication, ‘just the facts’ isn’t good enough

RT-EZ: A golden gate assembly toolkit for streamlined genetic engineering of rhodotorula toruloides

Stem Cell Reports announces five new early career editors

Support networks may be the missing link for college students who seek help for excessive drinking

The New England Journal of Medicine shines spotlight on forensic pathology

Scientists discover protein that helps lung cancer spread to the brain

Perceived social status tied to cardiovascular risks in women but not in men

Brain tumor growth patterns may help inform patient care management

This might be America's first campus tree inventory

Emoji use may impact relationship outcomes

Individual merit, not solidarity, prioritized by early childhood education policies

Preclinical study unlocks a mystery of rapid mouth healing

Extraterrestrial habitats: bioplastics for life beyond earth

U.S. military spending reductions could substantially lower energy consumption

Air pollution is linked to adverse birth outcomes in India

Using viral load tests to help predict mpox severity when skin lesions first appear

Engineered cell cross-talk unlocks CAR-T potential against glioblastoma

Regional disparities in US media coverage of archaeology research

Coral larvae travelling further makes populations stronger

First of its kind study for children with arthritis reveals possible new disease targets

Financing innovation: proposal for novel adaptive platform trial fund offers new model for ALS drug development

Disparities in treatment and referral after an opioid overdose among emergency department patients

[Press-News.org] Does BMO induced by mechanical stress progress to structural lesions?
Exploring MRI imaging findings in postpartum women