PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Shaping the future of polymer nanocarriers

Recent findings by CiQUS researchers group reveal how secondary structure in helical polymers influences their aggregation and size control. Light-triggered release offers tailored solutions for controlled substance delivery.

Shaping the future of polymer nanocarriers
2024-07-11
(Press-News.org) Scientists have taken a significant step towards the development of tailor-made chiral nanocarriers with controllable release properties. These nanocarriers, inspired by nature's helical molecules like DNA and proteins, hold immense potential for targeted drug delivery and other biomedical applications.

The study, led by Professors Emilio Quiñoá and Félix Freire at the Center for Research in Biological Chemistry and Molecular Materials (CiQUS), highlights the intricate relationship between the structure of helical polymers and their self-assembly into nanospheres. By carefully designing the secondary chain, the researchers were able to modulate the acidity of the polymers, influencing their aggregation patterns and leading to the formation of nanoespheres with varying densities. Intriguingly, the size of these nanoespheres could be precisely controlled by simply adjusting the water-to-solvent ratio during their preparation, eliminating the need for stabilizers. This eco-friendly approach paves the way for sustainable synthesis of these particles.

The researchers further demonstrated the remarkable ability to control the release of encapsulated substances within these nanoespheres using light. A photochemical reaction triggered the degradation of the polymers, releasing their cargo – in this case, tiny metallic and fluorescent particles. The chirality and folding of the helix played a crucial role in this process. Stretched helices exhibited slower photodegradation compared to their more compact counterparts. This opens up exciting possibilities for gradual release of encapsulated substances, a highly desirable feature for controlled drug delivery.

The findings, published in the renowned journal Angewandte Chemie, represent a significant advancement in understanding the governing parameters of helical polymer behavior. By manipulating these parameters, the researchers envision a broad spectrum of applications for these versatile compounds, spanning the fields of biology and materials science. This breakthrough paves the way for the development of next-generation nanocarriers with enhanced control over their properties and functions, offering promising avenues for targeted drug delivery, bioimaging, and nanomaterial design.

END

[Attachments] See images for this press release:
Shaping the future of polymer nanocarriers Shaping the future of polymer nanocarriers 2 Shaping the future of polymer nanocarriers 3

ELSE PRESS RELEASES FROM THIS DATE:

2000th ERC Proof of Concept grant awarded

2024-07-11
The grants – each worth €150,000 – help researchers to bridge the gap between the discoveries stemming from their frontier research and the practical application of the findings, including early phases of their commercialisation.    Nanda Rea’s new project, called DeepSpacePULSE, aims to facilitate deep space exploration. Currently, to find their way, spacecraft and satellites use up a lot of energy exchanging vital navigation information with mission coordinators on Earth. Using ERC Proof of Concept funding, Prof. Nanda Rea ...

Wild plants and crops don’t make great neighbors

Wild plants and crops don’t make great neighbors
2024-07-11
Native plants and non-native crops do not fare well in proximity to one another, attracting pests that spread diseases in both directions, according to two new UC Riverside studies.  “We have changed the landscape, and it’s created opportunities for pathogens to thrive,” said UCR entomologist Kerry Mauck, who co-authored the studies. “We have introduced pathogens that damage native plants, and on the other side of the coin we have endemic pathogens that mutate to infect ...

Movement sensors show promise in identifying horses at injury risk

2024-07-11
PULLMAN, Wash. – A small 3-ounce sensor capable of recording 2,400 data points of movement in just one second being tested and refined by researchers at Washington State University could be key in reducing the number of injuries to racehorses. Led by Dr. Warwick Bayly in WSU’s College of Veterinary Medicine, researchers used the biometric sensors, developed by the company StrideSAFE, to track thoroughbreds as they raced and trained at some of the top racetracks in the country. Using collected data, the team was able to identify miniscule stride changes associated with increased risk ...

Opening the right doors: “jumping gene” control mechanisms revealed

Opening the right doors: “jumping gene” control mechanisms revealed
2024-07-11
International joint research led by Akihisa Osakabe and Yoshimasa Takizawa of the University of Tokyo has clarified the molecular mechanisms in thale cresses (Arabidopsis thaliana) by which the DDM1 (Decreased in DNA Methylation 1) protein prevents the transcription of “jumping genes.” DDM1 makes “jumping genes” more accessible for transcription-suppressing chemical marks to be deposited. Because a variant of this protein exists in humans, the discovery provides insight into genetic conditions caused by such “jumping gene” mutations. The findings ...

Blood fat profiles confirm health benefits of replacing butter with high-quality plant oils

Blood fat profiles confirm health benefits of replacing butter with high-quality plant oils
2024-07-11
Switching from a diet high in saturated animal fats to one rich in plant-based unsaturated fats affects the fat composition in the blood, which in turn influences long-term disease risk. A recent study published in Nature Medicine, conducted by a team of researchers from Chalmers University of Technology, Sweden, the German Institute of Human Nutrition, Germany and several other universities, shows that it is possible to accurately measure diet-related fat changes in the blood and directly link them to the risk of developing cardiovascular disease and type 2 diabetes. “Our study confirms with even more certainty the health benefits of ...

Air pollution harms pollinators more than pests, study finds

2024-07-11
Bees and other beneficial bugs are disproportionately harmed by air pollution compared to crop-destroying pests, a new study published in Nature Communications has found. Researchers from the University of Reading analysed data from 120 scientific papers to understand how 40 types of insects in 19 countries respond to air pollutants like ozone, nitrogen oxides, sulfur dioxide and particulate matter. Pollinators - including bees and some moths and butterflies - experienced a 39% decline in foraging ...

Aperiodic approximants for relating quasicrystals and modulated structures

Aperiodic approximants for relating quasicrystals and modulated structures
2024-07-11
For a long time, scientists associated crystal structures with an ordered arrangement of atoms in a repeating lattice-like pattern, believing it to be the most stable configuration. However, by the 1960s, advancements in crystallography revealed materials that did not fit the traditional model. These structures exhibit a non-periodic or non-repeating pattern and are called aperiodic crystals. There are two types of aperiodic crystals: quasicrystals (QCs), which exhibit ordered but aperiodic arrangements, and incommensurately (IC) modulated structures, where a three-dimensional periodic lattice structure ...

Hydrogen flight looks ready for take-off with new advances

Hydrogen flight looks ready for take-off with new advances
2024-07-11
The possibility of hydrogen-powered flight means greater opportunities for fossil-free travel, and the technological advances to make this happen are moving fast. New studies from Chalmers University of Technology, in Sweden, show that almost all air travel within a 750-mile radius (1200 km) could be made with hydrogen-powered aircraft by 2045, and with a novel heat exchanger currently in development, this range could be even further.    “If everything falls into place, the commercialisation of hydrogen flight can go really fast now. As early as 2028, the first commercial hydrogen flights in Sweden could be in the air," says Tomas Grönstedt, Professor at Chalmers ...

Same workout, different weight loss: Signal molecule versions are key

Same workout, different weight loss: Signal molecule versions are key
2024-07-11
Some people lose weight slower than others after workouts, and a Kobe University research team found a reason. They studied what happens to mice that cannot produce signal molecules that respond specifically to short-term exercise and regulate the body’s energy metabolism. These mice consume less oxygen during workouts, burn less fat and are thus also more susceptible to gaining weight. Since the team found this connection also in humans, the newly gained knowledge of this mechanism might provide a pathway for treating obesity. It is well known that exercise leads to the ...

Trained peers are as effective as clinical social workers in reducing opioid overdose, new trial finds

2024-07-11
In Rhode Island, USA, over one in four emergency department (ED) patients at high risk of overdose has a non-fatal opioid overdose in the 18 months post-discharge.  A parallel, two-arm, randomized controlled trial conducted in Rhode Island of over 600 ED patients at high risk of opioid overdose found that support from a peer recovery support specialist (a trained support worker with lived experience of addiction) was as effective in reducing opioid overdose as support from a licensed clinical social worker.  In other words, interviewing and intervention techniques informed by lived ...

LAST 30 PRESS RELEASES:

Samuel Pepys’ fashion prints reveal his guilty pleasure: Fancy French clothes

New genetic test will eliminate a form of inherited blindness in dogs

Cancer risk: Most Australian welders exposed to high levels of dangerous fumes

Two-in-one mapping of temperature and flow around microscale convective flows

Texas A&M engineers explore intelligence augmentation to improve safety

ORNL economist honored at international hydropower conference

UCLA selected by Centers for Medicare & Medicaid Services to test Medicare dementia care model

Fish adjust reproduction in response to predators

DDX41 and its unique contribution to myeloid leukemogenesis

Digital games on vaping devices could lure more youth to nicotine addiction

Cracking the code of hydrogen embrittlement

Long-term results from Testicular Cancer treatment are positive, study shows

EPA awards UMass Amherst nearly $6.4 million to help shrink the steel industry’s carbon footprint

Valentina Greco takes on new position as President of the ISSCR

Komen supports UVA Engineering researchers targeting ‘triple negative' breast cancer

Panel issues first guidelines to prevent anal cancer in people with HIV

Estimating rainfall intensity using surveillance audio and deep-learning

Targeting factors for chemoprevention and cancer interception to tackle mesothelioma

New snake discovery rewrites history, points to North America’s role in snake evolution

Large and unequal life expectancy declines in India during COVID-19

A study of 156,000 UK residents found that urban residents score the lowest in social and economic satisfaction and well-being

Global study by Hawaiʻi Institute of Marine Biology demonstrates benefit of marine protected areas to recreational fisheries

Researchers clarify how soft materials fail under stress

Revolutionizing the abilities of adaptive radar with AI

Plastic waste can now be converted to electronic devices

Health equity scholar Darrell Hudson named Health Behavior and Health Education chair at the University of Michigan School of Public Health

Research will establish best ‘managed retreat’ practices for communities faced with climate change disaster

Marshall University awarded grant to further fentanyl addiction research

Wash U researchers shine light on amyloid architecture

New dawn for space storm alerts could help shield Earth's tech

[Press-News.org] Shaping the future of polymer nanocarriers
Recent findings by CiQUS researchers group reveal how secondary structure in helical polymers influences their aggregation and size control. Light-triggered release offers tailored solutions for controlled substance delivery.