Disproportionality analysis from World Health Organization data on semaglutide, liraglutide, and suicidality

JAMA Network Open

2024-08-20

(Press-News.org) About The Study: In this disproportionality study of an adverse drug reaction database, researchers identified a disproportionality signal of suicidal ideation with semaglutide, but not for liraglutide, particularly among patients with co-reported antidepressant use, a proxy for affective disorders (a notable exclusion criteria of premarketing clinical trials). A detected signal of semaglutide-associated suicidal ideation warrants urgent clarification.

Corresponding Author: To contact the corresponding author, Georgios Schoretsanitis, MD, PhD, email george.schor@gmail.com.

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(doi:10.1001/jamanetworkopen.2024.23385)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Disproportionality analysis from World Health Organization data on semaglutide, liraglutide, and suicidality

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