Disproportionality analysis from World Health Organization data on semaglutide, liraglutide, and suicidality

JAMA Network Open

2024-08-20

(Press-News.org) About The Study: In this disproportionality study of an adverse drug reaction database, researchers identified a disproportionality signal of suicidal ideation with semaglutide, but not for liraglutide, particularly among patients with co-reported antidepressant use, a proxy for affective disorders (a notable exclusion criteria of premarketing clinical trials). A detected signal of semaglutide-associated suicidal ideation warrants urgent clarification.

Corresponding Author: To contact the corresponding author, Georgios Schoretsanitis, MD, PhD, email george.schor@gmail.com.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2024.23385)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.23385?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=082024

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Individual- and community-level risk factors of cancer-related financial hardship among cancer survivors

2024-08-20

About The Study: In this cross-sectional study, approximately 50% of cancer survivors experienced cancer-related financial hardship, with a disproportionate number of survivors who were younger, were Medicare or Medicaid beneficiaries, were socioeconomically disadvantaged, and had advanced disease. Social vulnerability was independently associated with increasing levels of financial hardship, emphasizing the central role one’s community may play in cancer survivorship and the compounding financial detriments of residing in a socially vulnerable community. Corresponding ...

Can naloxone improve survival rates of patients with cardiac arrest?

2024-08-20

Patients who overdose on opioids and have a pulse are often given naloxone (Narcan) by first responders, a common life-saving measure. However, emergency medical service (EMS) agencies have different protocols for administering naloxone, so there is little evidence to support its use in patients without a pulse who experienced opioid-associated out of hospital cardiac arrest (OHCA). A recent study by UC Davis Health researchers set out to assess the effects of giving naloxone administration by paramedics to patients with OHCA. The study, published in Jama Network Open, ...

Cognitive behavioral therapy app improves anxiety in young adults

2024-08-20

Researchers at Weill Cornell Medicine and NewYork-Presbyterian found that a self-guided cognitive behavioral therapy (CBT) app, called Maya, significantly reduced anxiety in young adults struggling with mental health challenges. The decrease in anxiety symptoms was clinically and statistically significant at six weeks and continued at the 12-week follow-up period with improvement levels similar to anxiety medication studies. The study, published Aug. 20 in JAMA Network Open, looked at how young adults ages ...

ASBMB honors 10 scientists for scientific and community contributions

2024-08-20

The American Society for Biochemistry and Molecular Biology announced today the winners of its annual awards. Colleagues and other leaders in the field nominated the winners for making significant contributions to biochemistry and molecular biology as well as to the training and support of emerging scientists. The recipients will give talks about their work at the society’s 2025 annual meeting slated for April 12–15 in Chicago. In addition to cash prizes ranging from $2,000 to $35,000, each awardee will receive a plaque and transportation expenses to the annual meeting. Learn more about the ASBMB awards. Herbert Tabor ...

Using low-cost videoscopes to obtain accurate video “oral selfies” as screening for hpv-associated oropharyngeal cancer: a new screening technology?

2024-08-20

The rise in the incidence of oropharyngeal squamous cell carcinomas (OPSCCs) linked to human papillomavirus (HPV)-16 infection has become notable, surpassing cervical high-risk HPV infections by 2019. HPV-associated OPSCCs present a better prognosis compared to traditional oropharyngeal malignancies, largely due to lower correlations with chronic tobacco and alcohol use. Despite the sexually transmitted nature of HPV-associated OPSCCs, data on sexual behaviors is sparse in cancer registries, complicating correlation studies. Notably, high-risk factors in men include recent ...

PolyU scientists harness quantum microprocessor chips for revolutionary molecular spectroscopy simulation

2024-08-20

Quantum simulation enables scientists to simulate and study complex systems that are challenging or even impossible using classical computers across various fields, including financial modelling, cybersecurity, pharmaceutical discoveries, AI and machine learning. For instance, exploring molecular vibronic spectra is critical in understanding the molecular properties in molecular design and analysis. However, it remains a long-standing computationally difficult problem that cannot be efficiently solved using traditional super-computers. Researchers are diligently working on quantum computers and algorithms to ...

Black Americans at greater Alzheimer’s risk and treatment burden, less awareness of disease and symptoms

2024-08-20

INDIANAPOLIS – A new study examining older Black Americans’ perceptions of Alzheimer’s disease has found a lack of awareness of the devastating condition. The authors propose strategies for supporting brain health in this population. Absence of awareness of Alzheimer's disease may undermine Black Americans’ ability to identify potential risk of the disease and its impact on their community, said Johanne Eliacin, PhD, Regenstrief Institute, U.S. Department of Veterans Affairs and the Indiana University School of Medicine research scientist and study leader. ...

AI can help rule out abnormal pathology on chest x-rays

2024-08-20

OAK BROOK, Ill. – A commercial artificial intelligence (AI) tool used off-label was effective at excluding pathology and had equal or lower rates of critical misses on chest X-ray than radiologists, according to a study published today in Radiology, a journal of the Radiological Society of North America (RSNA). Recent developments in AI have sparked a growing interest in computer-assisted diagnosis, partly motivated by the increasing workload faced by radiology departments, the global shortage of radiologists and the potential for burnout in the field. Radiology practices have a high volume of unremarkable ...

Recent developments of vaccines as a precision medicine approach to cancer immunotherapy

2024-08-20

The field of precision medicine, especially in the context of cancer immunotherapy, has seen significant advancements in recent years. Precision medicine tailors treatment to the unique genetic and molecular profile of each patient, moving away from conventional one-size-fits-all approaches. This personalized strategy aims to minimize side effects and maximize therapeutic efficacy. A key component of this approach is the use of immune checkpoint inhibitors (ICIs), monoclonal antibodies that target immunosuppressive molecules such as PD-1, PD-L1, and CTLA-4. These ICIs have demonstrated considerable ...

Enhancing brain-computer interface performance through tactile and motor imagery: A revolutionary EEG study

2024-08-20

In a groundbreaking study recently published, researchers from Zhejiang University have unveiled significant findings that could enhance brain-computer interface (BCI) technologies, marking a crucial step towards more intuitive neuroprosthetic control and advanced rehabilitation therapies. The study, titled "Neural Correlates of Motor/Tactile Imagery and Tactile Sensation in a BCI paradigm: A High-Density EEG Source Imaging Study," employed high-density electroencephalogram (EEG) recordings to delve into the neural dynamics of motor and ...

Disproportionality analysis from World Health Organization data on semaglutide, liraglutide, and suicidality

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: