(Press-News.org) About The Study: In this study, women with hepatocellular carcinoma were less likely to receive a deceased-donor liver transplant and more likely to die while wait-listed than men with hepatocellular carcinoma; these differences were largely (but not entirely) explained by sex-based differences in candidate size. For candidates listed with exception scores, additional changes to allocation policy are needed to resolve the sex disparity, including solutions to improve access to size-matched donor livers for smaller candidates.
Corresponding Author: To contact the corresponding author, Heidi Yeh, MD, email hyeh@mgh.harvard.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamasurg.2024.3498)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/jamasurg.2024.3498?guestAccessKey=df6f6278-2b77-43b1-ab49-8e5dfe7a73d0&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=090424
END
Sex and size disparities in access to liver transplant for patients with hepatocellular carcinoma
JAMA Surgery
2024-09-04
ELSE PRESS RELEASES FROM THIS DATE:
The world's first nuclear clock
2024-09-04
For many years, scientists all around the world have been working towards this goal, now suddenly things are happening very fast: it was only in April that a team led by Prof Thorsten Schumm (TU Wien, Vienna) announced a major success. For the first time, an atomic nucleus had been switched from one state to another using a laser – an effect that can be used for high-precision measurements. Now, just a few weeks later, this thorium transition was successfully applied in practice: TU Wien and JILA/NIST (USA) succeeded in combining a high-precision optical atomic clock with ...
H5 influenza vaccines: what needs to be done to reduce the risk of a pandemic
2024-09-04
WASHINGTON — As the global threat of H5N1 influenza looms with outbreaks across species and continents including the U.S., three international vaccine and public health experts say it is time to fully resource and support a robust strategy to address this and future potential pandemic influenza threats, including to consider voluntary vaccination for those now at exposure risk.
“At this critical juncture, decisions about vaccine development, stockpiling, and deployment will shape our ability to respond to immediate and future pandemic risks,” write Jesse Goodman, MD, PhD; Rick A. Bright, PhD; and Nicole Lurie, MD, ...
Epigenetic changes reprogram astrocytes into brain stem cells
2024-09-04
Resting brain stem cells hardly differ from normal astrocytes, which support the nerve cells in the brain. How can almost identical cells perform such different functions? The key lies in the methylation of their genetic material, which endowes these special astrocytes with stem cell properties. Scientists from the German Cancer Research Center (DKFZ) and Heidelberg University have published their findings in the journal Nature. In mice, the researchers showed that experimentally induced lack of blood ...
Sex hormones modulate the immune system to influence disease risk differently
2024-09-04
Researchers have uncovered how hormones profoundly affect our immune systems, explaining why men and women are affected by diseases differently.
Scientists from the Karolinska Institutet in Sweden and Imperial College London have shown for the first time which aspects of our immune systems are regulated by sex hormones, and the impacts this has on disease risk and health outcomes in males and females.
It is well established that diseases can affect men and women differently, due to subtle differences ...
Researchers identify mechanism underlying allergic itching, and show it can be blocked
2024-09-04
Why do some people feel itchy after a mosquito bite or exposure to an allergen like dust or pollen, while others do not? A new study has pinpointed the reason for these differences, finding the pathway by which immune and nerve cells interact and lead to itching. The researchers, led by allergy and immunology specialists at Massachusetts General Hospital, a founding member of the Mass General Brigham healthcare system, then blocked this pathway in preclinical studies, suggesting a new treatment approach for allergies. The findings are published in Nature.
“Our research provides ...
Brain scanning approach shows wiring of depression
2024-09-04
By repeatedly scanning the brains of a small group of patients for a year and a half, Weill Cornell Medicine researchers have identified a distinct pattern of neuronal interactions that appears to predispose some people to developing depression.
Published Sept. 4 in Nature, the work highlights the potential of a new “deep scanning” approach to help predict a person’s susceptibility to depression and other neuropsychiatric conditions and may guide the development of novel treatments.
Neuroscientists have long relied on functional magnetic resonance imaging (fMRI) to identify patterns of activity ...
Heart drug improved exercise tolerance in clinical trial of patients with hypertrophic obstructive cardiomyopathy
2024-09-04
Exercise intolerance is often severe among patients with cardiovascular disease and can impose significant limitations on their physical abilities and quality of life. Medications known as cardiac myosin inhibitors (CMIs) are being developed to help patients with hypertrophic obstructive cardiomyopathy (HOCM), a disease in which the heart muscle becomes thickened leading to reduced blood flow out of the heart. In a new analysis led by researchers from Mass General Brigham, investigators probed multiple exercise response ...
Menstrual cycle influences the spread of mutant cells in mammary tissue
2024-09-04
Leuven/Amsterdam/Cambridge, 5 September– A team of researchers at the VIB-KU Leuven Center for Cancer Biology, the Netherlands Cancer Institute and Oncode Institute and the University of Cambridge have discovered that a defensive mechanism connected to the menstrual cycle plays a role in spreading mutant cells within mammary tissue. A new study published in Nature describes how the growth and subsequent removal of extra milk ducts in breast tissue during the menstrual cycle can contribute to the spread of mutant cells leading to large mutant fields prone to develop tumors.
Although tissue in healthy individuals may look completely normal, ...
Study shows how oceans are key to addressing global challenges
2024-09-04
New research shows how oceans can be used to help address major challenges such as the shortage of antimicrobial medicines, solutions for plastic pollution and novel enzymes for genome editing.
In the past 20 years, scientists have greatly increased the number of microbial genomes they have collected from the ocean. However, using this information for biotechnology and medicine has been difficult.
For this new study, led by BGI Research in China in collaboration with the Shandong University, Xiamen University, ...
Immune cells prevent lung healing after viral infection
2024-09-04
Investigators involved in a multicenter study co-led by Cedars-Sinai discovered a pathway by which immune cells prevent the lungs’ protective barrier from healing after viral infections like COVID-19. The findings, published in Nature may lead to new therapeutic treatment options.
The COVID-19 pandemic revealed how viral infections can cause long-lasting effects—a condition called long COVID. Also known as post-acute sequelae of SARS-CoV-2, long COVID has left a devastating trail of people who continue to live with ...
LAST 30 PRESS RELEASES:
Megalodon’s body size and form uncover why certain aquatic vertebrates can achieve gigantism
A longer, sleeker super predator: Megalodon’s true form
Walking, moving more may lower risk of cardiovascular death for women with cancer history
Intracortical neural interfaces: Advancing technologies for freely moving animals
Post-LLM era: New horizons for AI with knowledge, collaboration, and co-evolution
“Sloshing” from celestial collisions solves mystery of how galactic clusters stay hot
Children poisoned by the synthetic opioid, fentanyl, has risen in the U.S. – eight years of national data shows
USC researchers observe mice may have a form of first aid
VUMC to develop AI technology for therapeutic antibody discovery
Unlocking the hidden proteome: The role of coding circular RNA in cancer
Advancing lung cancer treatment: Understanding the differences between LUAD and LUSC
Study reveals widening heart disease disparities in the US
The role of ubiquitination in cancer stem cell regulation
New insights into LSD1: a key regulator in disease pathogenesis
Vanderbilt lung transplant establishes new record
Revolutionizing cancer treatment: targeting EZH2 for a new era of precision medicine
Metasurface technology offers a compact way to generate multiphoton entanglement
Effort seeks to increase cancer-gene testing in primary care
Acoustofluidics-based method facilitates intracellular nanoparticle delivery
Sulfur bacteria team up to break down organic substances in the seabed
Stretching spider silk makes it stronger
Earth's orbital rhythms link timing of giant eruptions and climate change
Ammonia build-up kills liver cells but can be prevented using existing drug
New technical guidelines pave the way for widespread adoption of methane-reducing feed additives in dairy and livestock
Eradivir announces Phase 2 human challenge study of EV25 in healthy adults infected with influenza
New study finds that tooth size in Otaria byronia reflects historical shifts in population abundance
nTIDE March 2025 Jobs Report: Employment rate for people with disabilities holds steady at new plateau, despite February dip
Breakthrough cardiac regeneration research offers hope for the treatment of ischemic heart failure
Fluoride in drinking water is associated with impaired childhood cognition
New composite structure boosts polypropylene’s low-temperature toughness
[Press-News.org] Sex and size disparities in access to liver transplant for patients with hepatocellular carcinomaJAMA Surgery