PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

High-Dose vitamin D3 does not provide benefit for metastatic colorectal cancer

High-Dose vitamin D3 does not provide benefit for metastatic colorectal cancer
2024-09-15
(Press-News.org) RESEARCH SUMMARY

Study Title: SOLARIS (Alliance A021703): A multicenter double-blind phase III randomized clinical trial of vitamin D combined with standard chemotherapy plus bevacizumab in patients with previously untreated metastatic colorectal cancer.

Publication: European Society for Medical Oncology 2024 Abstract LBA26

Dana-Farber Cancer Institute authors: Kimmie Ng, MD, MPH, Nadine McCleary, MD, MPH, Jeffrey A. Meyerhardt, MD, MPH

Summary: A double-blind randomized phase 3 clinical trial led by Dana-Farber Cancer Institute researchers and conducted across several hundred cancer centers in the U.S. tested the addition of high-dose vitamin D3 to standard treatment for patients with untreated metastatic colorectal cancer. More than 450 patients received standard chemotherapy plus bevacizumab and were randomized to high-dose or standard dose vitamin D3. The team observed no additional concerning side-effects or toxicities with the addition of high-dose vitamin D3. However, the addition of high-dose vitamin D3 to standard treatment did not delay the progression of cancer more so than standard-dose vitamin D3, according to the team’s analysis after a median 20-month follow up. A potential benefit for high-dose vitamin D3 was observed for patients with left-sided disease (i.e., primary tumors that arise in the descending colon, sigmoid colon, or rectum) and requires further investigation.

Significance: The SOLARIS trial was inspired by previous research suggesting that higher levels of vitamin D in the blood are associated with improved survival for metastatic colorectal cancer and that the addition of high-dose vitamin D3 to standard therapy could potentially improve progression free survival. The SOLARIS results suggest, however, that high-dose vitamin D3 cannot be recommended as a treatment for patients with untreated metastatic colon cancer.

Funding: National Cancer Institute; Pharmavite

Contact:  Victoria Warren, victoria_warren@dfci.harvard.edu

END

[Attachments] See images for this press release:
High-Dose vitamin D3 does not provide benefit for metastatic colorectal cancer

ELSE PRESS RELEASES FROM THIS DATE:

Long-term metastatic melanoma survival dramatically improves on immunotherapy

Long-term metastatic melanoma survival dramatically improves on immunotherapy
2024-09-15
Long-term data from a landmark international trial show about half of patients with metastatic melanoma treated with a combination of immune checkpoint inhibitors survive cancer-free for 10 years or more, according to a new report from Weill Cornell Medicine and Dana-Farber Cancer Center investigators and their colleagues. The 10-year follow-up study, published Sept. 15 in the New England Journal of Medicine, will bring the phase 3 CheckMate 067 trial to a close. The trial, which followed 945 patients treated at 137 sites in 21 countries, demonstrated that combining ...

Contrail avoidance is less likely to damage climate by mistake than previously thought

2024-09-15
A new study allays fears that rerouting flights to avoid forming climate-warming contrails could result in inadvertently making climate warming worse.  Researchers from Sorbonne Universite and the University of Reading found that for most flights that form contrails in the North Atlantic, the climate benefit of avoiding the contrail outweighs the extra carbon dioxide emitted from flying a different route.   Contrail avoidance requires comparing the climate impacts of carbon dioxide and contrails, called CO2 equivalence. Different methods have been proposed, and the choice of which has been largely political. Scientists feared that some choices ...

Breast cancer research: New studies show how post-treatment lifestyle choices shape long-term outcomes after diagnosis

Breast cancer research: New studies show how post-treatment lifestyle choices shape long-term outcomes after diagnosis
2024-09-15
Young patients can safely breastfeed without increasing the risk of cancer recurrence or new cancer in the opposite breast Telephone-based intervention can successfully prompt patients who are overweight to exercise more, lowering their weight BARCELONA, SPAIN – Three studies led by Dana-Farber Cancer Institute researchers have encouraging implications for patients with breast cancer. Two studies focus on breastfeeding after breast cancer diagnosis and treatment. The studies found it was safe and feasible for young patients carrying specific genetic variations to breastfeed without raising their risk of a cancer recurrence or a cancer in the other breast, and that it was safe ...

New meta-analysis shows that hormone therapy can significantly reduce insulin resistance

2024-09-14
CLEVELAND, Ohio (Sept 10, 2024) –Menopausal women are at greater risk of insulin resistance as a result of declining estrogen levels. Previous studies evaluating the potential benefits of hormone therapy on insulin resistance have produced mixed results. However, a new meta-analysis of 17 different randomized, controlled trials suggests hormone therapy can be beneficial. Results of the meta-analysis will be presented at the 2024 Annual Meeting of The Menopause Society in Chicago September 10-14.   Insulin resistance can occur in men or women, but menopausal women are at ...

Genomics reveals sled dogs’ Siberian lineage

2024-09-14
ITHACA, N.Y. – New research co-led by Cornell University examines thousands of years of Arctic sled dog ancestry and reveals when and how Siberian and Alaskan sled dogs’ DNA mixed. “There was a real concern from Siberian breeders – who were mostly racing their dogs – that they were sending out their dogs’ DNA samples for analysis, more for the context of health traits, and they were getting breed ancestry information back that said their dog was not 100% Siberian husky,” said Heather Huson, a former ...

ESMO: Combination therapy reduced agitated delirium in patients with advanced cancers

2024-09-14
ABSTRACT: 1476O  BARCELONA, Spain ― Treatment with a combination of haloperidol and lorazepam reduced symptoms of agitated delirium, a common end-of-life condition for patients with advanced cancers, compared with haloperidol alone, according to a new study led by researchers at The University of Texas MD Anderson Cancer Center. The findings were presented today at the 2024 European Society for Medical Oncology (ESMO) Congress.   Agitated delirium occurs when a patient’s brain function begins to deteriorate as their cancer advances, resulting in many patients beginning to behave aggressively or abnormally. Although the use of medication ...

SOPHiA GENETICS presents ground-breaking multimodal research on AI-driven patient stratification at ESMO 2024

SOPHiA GENETICS presents ground-breaking multimodal research on AI-driven patient stratification at ESMO 2024
2024-09-14
Boston, MA and Rolle, Switzerland, September 14, 2024 – SOPHiA GENETICS (Nasdaq: SOPH), a cloud-native healthcare technology company and a leader in data-driven medicine, will unveil new research at the European Society for Medical Oncology (ESMO) 2024. The study, conducted in collaboration with AstraZeneca, leverages advanced AI-driven techniques to identify subgroups of stage IV non-small cell lung cancer (NSCLC) patients who could most benefit from the addition of tremelimumab to durvalumab and chemotherapy. The research is a retrospective, multimodal analysis of the POSEIDON Phase 3 clinical trial (NCT03164616). This trial originally demonstrated that the combination of tremelimumab, ...

Mitochondria at the crossroads of cholestatic liver injury: Targeting novel therapeutic avenues

Mitochondria at the crossroads of cholestatic liver injury: Targeting novel therapeutic avenues
2024-09-14
Bile acids are essential signaling molecules derived from cholesterol metabolism in the liver and are crucial for the digestion and absorption of fats. These molecules undergo further modification in the intestines by the gut microbiome. However, disruptions in bile flow, a condition known as cholestasis, can lead to the pathological accumulation of hydrophobic BAs in the liver and bloodstream. This accumulation not only exacerbates liver damage but also induces significant disturbances in cellular processes. The review focuses on recent developments in understanding how BAs contribute to liver injury by affecting mitochondrial function, endoplasmic reticulum ...

Scientists reveal new design for cells turning carbon dioxide into a green fuel

Scientists reveal new design for cells turning carbon dioxide into a green fuel
2024-09-14
Tokyo, Japan – Researchers from Tokyo Metropolitan University have made strides forward in realizing industrial conversion of bicarbonate solution made from captured carbon to a formate solution, a green fuel. Their new electrochemical cell, with a porous membrane layer in between the electrodes, overcomes major issues suffered in reactive carbon capture (RCC) and achieves performances rivaling energy-hungry gas-fed methods. Processes like theirs directly add value to waste streams and are key to realizing net zero emissions.   Carbon capture technology ...

Paying attention to errors can improve fused remote monitoring of lakes, researchers say

2024-09-14
Lakes can tip the scales from healthy to potential environmental hazard quickly when they become eutrophic. In this state, an abundance of nutrients accelerates algae growth, which then crowd the water’s surface and block light from reaching organisms below. Without light, they can’t make oxygen and life in the water begins to die off. Luckily, researchers can monitor inland lakes for eutrophication with remote sensing technologies; however, those technologies could be adjusted to make more accurate assessments, according to researchers based in China. The team published their evaluation of the technologies, as well as recommended paths ...

LAST 30 PRESS RELEASES:

Are lifetimes of big appliances really shrinking?

Pink skies

Monkeys are world’s best yodellers - new research

Key differences between visual- and memory-led Alzheimer’s discovered

% weight loss targets in obesity management – is this the wrong objective?

An app can change how you see yourself at work

NYC speed cameras take six months to change driver behavior, effects vary by neighborhood, new study reveals

New research shows that propaganda is on the rise in China

Even the richest Americans face shorter lifespans than their European counterparts, study finds

Novel genes linked to rare childhood diarrhea

New computer model reveals how Bronze Age Scandinavians could have crossed the sea

Novel point-of-care technology delivers accurate HIV results in minutes

Researchers reveal key brain differences to explain why Ritalin helps improve focus in some more than others

Study finds nearly five-fold increase in hospitalizations for common cause of stroke

Study reveals how alcohol abuse damages cognition

Medicinal cannabis is linked to long-term benefits in health-related quality of life

Microplastics detected in cat placentas and fetuses during early pregnancy

Ancient amphibians as big as alligators died in mass mortality event in Triassic Wyoming

Scientists uncover the first clear evidence of air sacs in the fossilized bones of alvarezsaurian dinosaurs: the "hollow bones" which help modern day birds to fly

Alcohol makes male flies sexy

TB patients globally often incur "catastrophic costs" of up to $11,329 USD, despite many countries offering free treatment, with predominant drivers of cost being hospitalization and loss of income

Study links teen girls’ screen time to sleep disruptions and depression

Scientists unveil starfish-inspired wearable tech for heart monitoring

Footprints reveal prehistoric Scottish lagoons were stomping grounds for giant Jurassic dinosaurs

AI effectively predicts dementia risk in American Indian/Alaska Native elders

First guideline on newborn screening for cystic fibrosis calls for changes in practice to improve outcomes

Existing international law can help secure peace and security in outer space, study shows

Pinning down the process of West Nile virus transmission

UTA-backed research tackles health challenges across ages

In pancreatic cancer, a race against time

[Press-News.org] High-Dose vitamin D3 does not provide benefit for metastatic colorectal cancer