Hospital strain during the COVID-19 pandemic and outcomes in older racial and ethnic minority adults

JAMA Network Open

2024-10-15

(Press-News.org) About The Study: In this cross-sectional study, older adults hospitalized with sepsis were more likely to die or experience major morbidity as the hospital COVID-19 burden increased. These increases in adverse outcomes were greater in magnitude among members of minority populations than for white individuals.

Corresponding Author: To contact the corresponding author, Laurent G. Glance, MD, email laurent_glance@urmc.rochester.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2024.38563)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.38563?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=101524

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Scientists unveils key role of “selfish DNA” in early human development

2024-10-15

A critical transition in early human development is regulated not by our own genes, but by DNA elements called transposons that can move around the genome, Sinai Health researchers have found. This remarkable discovery challenges our previous understanding of these elusive DNA segments, shedding new light on the roles they play in human development and disease. “People tend to think of transposons as akin to viruses where they hijack our cells for the sole purpose of propagating themselves,” says study’s senior co-author Dr. Miguel Ramalho-Santos, Senior Investigator at the Lunenfeld-Tanenbaum Research Institute (LTRI), part of Sinai Health, and Professor ...

Bonobos may be more vulnerable than previously thought, suggests genetics study

2024-10-15

Bonobos, endangered great apes that are among our closest relatives, might be more vulnerable than previously understood, finds a genetics study led by a UCL researcher that reveals three distinct populations. The three groups of bonobos have been living separately in different regions in Central Africa for tens of thousands of years, according to the study published in Current Biology by an international research team co-led by UCL, University of Vienna, and Max Planck Institute for Evolutionary Anthropology ...

Scripps Research scientists discover chemical probes for previously “undruggable” cancer target

2024-10-15

LA JOLLA, CA—Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations can enable these types of cancers to grow and proliferate. Today, FOXA1 is notoriously difficult to block with drugs—but that may soon change. Scripps Research scientists have identified a crucial binding site on FOXA1 that could pave the way for future cancer treatments. The team’s findings, which were published in Molecular Cell on October 15, 2024, also mapped out how tiny drug-like chemical compounds—called small molecules—interact with the protein. While ...

Giant Magellan telescope begins primary mirror support system testing

2024-10-15

TUCSON, AZ — October 15, 2024 — The Giant Magellan Telescope today announced the successful installation of one of its completed 8.4-meter-diameter primary mirrors into a support system prototype at the University of Arizona’s Richard F. Caris Mirror Lab. This highly sophisticated system — comparable in size to half a basketball court and containing three times the number of parts of a typical car — is vital to the telescope’s optical performance and precision control. The milestone marks the start of a six-month optical testing phase to demonstrate that the support system can control the mirror as required, validating the revolutionary capabilities ...

Experimental cancer drug eliminates bone metastases caused by breast cancer in lab models

2024-10-15

In a new study led by Johns Hopkins Medicine, the drug RK-33 has demonstrated promise in treating breast cancer that has spread to the bone (breast cancer bone metastasis). RK-33 was previously shown to help treat other types of cancer and viral illnesses. Patients with breast cancer and bone metastasis have limited treatment options and often rely on palliative care to ease difficult symptoms, including frailty and pain. In most cases, breast cancer with bone metastasis is incurable. Now, corresponding author Venu Raman, Ph.D., ...

Political candidates who fight climate change stand to benefit in election

2024-10-15

A majority of Floridians expressed support for political candidates who fight climate change in a new Florida Atlantic University survey. The survey found that nearly 52% of respondents agreed that a candidate with a record of reducing climate impacts was more likely to get their vote. The Invading Sea’s Florida Climate Survey also revealed strong support in the state for increasing renewable energy use and teaching climate science in K-12 classrooms. The survey is the 11th conducted by the FAU Center for Environmental Studies ...

Stand up to Cancer announces new grants supporting pioneering research in six cancer types

2024-10-15

LOS ANGELES – Oct. 15, 2024 – Stand Up To Cancer® (SU2C) today announced grants to several teams of leading cancer investigators in support of cutting-edge research in a variety of cancers including head and neck, pediatric, pancreatic, breast, rectal and gastro-esophageal cancers, as well as research focused on how the microbiome communicates with the immune system. “These new grants emphasize SU2C’s support of collaborative, trailblazing research that pushes the field forward and helps people impacted by some of the most common or difficult-to-treat cancers,” said Julian Adams, Ph.D., president and CEO of SU2C. “With an emphasis on answering ...

Researchers awarded $1.3M to help military Veterans battling Acute Myeloid Leukemia

2024-10-15

CLEVELAND—With a new four-year, $1.3 million grant from the U.S. Department of Veterans Affairs, researchers at Case Western Reserve University are investigating a new approach to treat Acute Myeloid Leukemia (AML) in military Veterans. AML is the most common form of blood cancer in adults, and many patients suffer relapses—especially Veterans, due to exposure to harmful chemicals and radiation during active duty, according to the National Center for Biotechnology Information. There is no effective treatment for AML and, according to the National Institutes of Health, half of treated patients suffer a relapse after therapy—mainly ...

New hub for high-energy astrophysics — CTAO Science Data Management Centre opens at DESY in Zeuthen

2024-10-15

Zeuthen, Germany – On 14 October 2024, the Cherenkov Telescope Array Observatory (CTAO), along with hosting partners and shareholders Deutsches Elektronen-Synchrotron DESY, celebrated the official inauguration of the Science Data Management Centre (SDMC) on the DESY campus in Zeuthen, Germany. The ceremony, chaired by Prof. Christian Stegmann, Head of DESY Zeuthen, was opened by Mario Brandenburg, Parliamentary State Secretary at the German Federal Ministry of Education and Research (BMBF), and Tobias Dünow, State Secretary at ...

JMIR publications CEO and Executive Editor Gunther Eysenbach achieves #1 ranking as most cited researcher in Medical Informatics for fifth consecutive year

2024-10-15

Toronto, ON (October 14, 2024) – JMIR Publications is proud to announce that Gunther Eysenbach, founder, CEO and executive editor, has once again been named the #1 most cited researcher in the subfield of medical informatics by Stanford/Elsevier’s Top 2% Scientists rankings. This marks the fifth consecutive year that Dr Eysenbach has secured this prestigious position, reaffirming his status as a leading authority and driving force in the field. He is also ranked #36 in the Top 100 Scientists in Information & Communication ...

CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury

Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1

Single-cell RNA sequencing reveals Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic ce

Hospital strain during the COVID-19 pandemic and outcomes in older racial and ethnic minority adults

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: