(Press-News.org)
“Of note, participants with high serum levels of FGF21 more frequently had metabolic complications, such as hypertension, obesity, diabetes, hypercholesterolemia, and hypertriglyceridemia.”
BUFFALO, NY- October 17, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 19 on September 18, 2024, entitled, “Fibroblast growth factor 21 inversely correlates with survival in elderly population – the results of the Polsenior2 study.”
As noted in the abstract, fibroblast growth factor 21 (FGF21) is a liver-secreted hormone involved in regulating lipid, glucose, and energy metabolism. Its serum concentration increases with age and is elevated in various diseases. FGF21 is currently being investigated for its potential as a biomarker and therapeutic target.
In their paper, Polish researchers Gabriela Handzlik, Aleksander J. Owczarek, Andrzej Więcek, Małgorzata Mossakowska, Tomasz Zdrojewski, Anna Chudek, Magdalena Olszanecka-Glinianowicz, and Jerzy Chudek from the Medical University of Silesia in Katowice, the International Institute of Molecular and Cell Biology in Warsaw, and the Medical University of Gdansk aimed to assess the prognostic value of FGF21 in an older, population-based cohort from the PolSenior2 study.
The researchers report that in a sub-analysis of 3,512 individuals aged 60 and older, stratified into tertiles based on FGF21 levels, the survival estimate was worse in participants with middle and high FGF21 levels compared to those in the lowest tertile. These findings were supported by univariable Cox regression analysis, where participants in the middle and high FGF21 tertiles, after adjusting for age, had a 1.43-fold (HR 1.31; 95% CI, 1.05–1.62) and 2.56-fold (HR 1.94; 95% CI, 1.59–2.37) increased risk of mortality, respectively, compared to the lowest tertile. In multivariable Cox regression analysis, the highest FGF21 levels were independently associated with increased mortality (HR 1.53; 95% CI, 1.22–1.92), regardless of co-morbidities and blood parameters.
"These results indicate that higher serum FGF21 concentration is an independent predictor of all-cause mortality in the general population of older adults.”
Continue reading: DOI: https://doi.org/10.18632/aging.206114
Corresponding Author: Gabriela Handzlik - ghandzlik@sum.edu.pl
Keywords: aging, fibroblast growth factor 21, survival, population-based study, longevity
Click here to sign up for free Altmetric alerts about this article.
About Aging:
The journal Aging aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)
Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).
Please visit our website at www.Aging-US.com and connect with us:
Facebook
X
Instagram
YouTube
LinkedIn
Reddit
Pinterest
Spotify, and available wherever you listen to podcasts
Click here to subscribe to Aging publication updates.
For media inquiries, please contact media@impactjournals.com.
Aging (Aging-US) Journal Office
6666 E. Quaker St, Suite 1
Orchard Park, NY 14127
Phone: 1-800-922-0957, option 1
END
Many plankton journey from the cold, dark depths of our oceans to the surface, only to eventually drift down again into the darkness in a perpetual rhythm. Yet, how single-celled phytoplankton, most of which have no appendages to help them swim, make this pilgrimage has remained a mystery. In a paper publishing October 17 in the Cell Press journal Current Biology, researchers describe a species of bioluminescent phytoplankton, called Pyrocystis noctiluca, that balloons to six times their original size of a few hundred microns. This massive inflation allows the plankton to journey up to 200 meters toward the ocean’s surface to capture sunlight, then ...
Glioblastomas are aggressive brain tumors with a median survival time of less than 22 months despite standard therapy including surgery, irradiation, and chemotherapy. It has become clear in recent years that not all cells within the brain tumor have an equal potential to divide and drive tumor growth. As such, a fraction of tumor cells called brain tumor stem cells (BTSCs) are thought to be the primary origin of tumor re-growth after surgery in addition to being resistant to standard treatments including chemotherapy and irradiation. Therefore, targeting BTSCs may be a way to effectively treat glioblastomas.
In an effort to rapidly identify ...
It may soon be possible to determine which patients with a type of liver cancer called hepatocellular carcinoma would benefit from immunotherapy, according to a preclinical study by Weill Cornell Medicine investigators.
The study, published Oct. 17 in Molecular Cell, provides new insights into a pair of proteins, called p62 and NBR1, and their opposing functions in regulating the interferon response in hepatic stellate cells, a critical immune component in the liver’s fight against tumors. The study demonstrates that high levels of the immune-suppressing NBR1 in these specialized cells may identify patients who are unlikely to respond ...
About The Study: This meta-analysis found that an estimated 2.56% of people 40 years or older have glaucoma, slightly more than estimated by previous studies. Black individuals are disproportionately affected. Prevalence estimates at the state and county level can help guide public health planning.
Corresponding Author: To contact the corresponding author, Joshua R. Ehrlich, MD, MPH, email joshre@umich.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamaophthalmol.2024.3884)
Editor’s ...
About The Study: Electric fan use did not lower peak core temperature in older adults exposed to extreme indoor heat. Reductions in end-exposure core temperature and heart rate were observed, but they were small and of questionable clinical importance. Neither exceeded previous suggestions for clinical significance. Consistent with recent modeling, these data do not support fans as an efficacious standalone cooling intervention for older adults in hot indoor environments (>33-35 °C).
Corresponding Author: To contact the corresponding author, Glen P. Kenny, PhD, email gkenny@uottawa.ca.
To ...
About The Study: Individuals receiving methadone had a lower risk of treatment discontinuation compared with those who received buprenorphine/naloxone. The risk of mortality while receiving treatment was similar between medications.
Corresponding Author: To contact the corresponding author, Bohdan Nosyk, PhD, email bnosyk@sfu.ca.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jama.2024.16954)
Editor’s Note: Please see the article for additional information, including ...
Dusty ice exposed at the surface of Mars could provide the conditions necessary for the presence of photosynthetic life, according to a modelling study. The findings, published in Communications Earth & Environment, suggest that ice deposits located in the planet’s mid-latitudes should be a key location in any search for life on Mars.
High levels of harmful ultraviolet radiation from the Sun make current life on the surface of Mars almost certainly impossible. However, a sufficiently thick layer of ice can absorb this radiation and could protect cells living below its surface. Any life in these conditions ...
The Dream Chemistry Award (DCA) is a one-of-a-kind competition dedicated to recognizing young scientists who dream of tackling fundamental problems in chemistry and related disciplines with visionary ideas. Established in 2013 by the Institute of Physical Chemistry of the Polish Academy of Sciences (IChF), the award aims to support emerging talents in realizing their scientific dreams. Since 2017, it has been organized jointly with the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague), with the finals alternating between Prague and Warsaw.
The Dream Chemistry Award empowers those pursuing ...
In the high-stakes world of aviation, a pilot's ability to perform under stress can mean the difference between a safe flight and disaster. Comprehensive and precise training is crucial to equip pilots with the skills needed to handle these challenging situations.
Pilot trainers rely on augmented reality (AR) systems for teaching, by guiding pilots through various scenarios so they learn appropriate actions. But those systems work best when they are tailored to the mental states of the individual subject.
Enter HuBar, a novel visual analytics tool designed to summarize and compare task performance ...
Recently, a Chinese research team reported the discovery of abiotic organic compounds in the oceanic crust of the Southwest Indian Ridge and proposed a molecular mechanism for organic condensation.
This breakthrough followed the team’s discovery of nanoscale abiotic organic matter in mantle rocks from the Yap Trench in 2021. It represents a significant advance in research on deep-sea carbon cycling and the origin of life, shedding light on key pathways for abiotic organic synthesis in nature.
The scientists published their findings in the Proceedings ...
