PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Wyss Institute’s iNodes team receives ARPA-H Sprint for Women’s Health award to advance the first implantable immune organs to treat ovarian cancer

iNodes is a new treatment paradigm in personalized immunotherapy with the potential to prolong the lives of many patients with advanced ovarian cancer

Wyss Institute’s iNodes team receives ARPA-H Sprint for Women’s Health award to advance the first implantable immune organs to treat ovarian cancer
2024-11-12
(Press-News.org)

By Benjamin Boettner

 

(BOSTON) — Ovarian cancer is more deadly than any other type of female reproductive organ cancer. It is estimated that in 2024, in the U.S. alone, more than 12,000 women will die from the disease because available therapies are not effective. To help overcome this striking deficit in women’s health, ARPA-H has selected a team at the Wyss Institute at Harvard University as an awardee of its Sprint for Women’s Health effort to develop “iNodes” – implantable lymphoid organs containing patients’ immune cells – as an entirely novel form of personalized immunotherapy to treat ovarian cancer.

 

The dismal outcomes of ovarian cancer are due to the fact that it is typically diagnosed at later stages of the disease: most early ovarian tumors are difficult or impossible to feel in pelvic exams and symptoms can also be caused by less serious conditions, including heartburn, indigestion, and constipation. At the time of diagnosis, about 80% of ovarian cancer patients have developed metastatic disease, and half of these women won’t survive the next five years. 

 

iNodes are based on the important finding that the fortunate minority of ovarian cancer patients who survive the disease frequently develop lymph node-like structures known as “lymphoid organs” in their tumors. Functioning as newly formed immune command centers, these lymphoid organs reprogram the immune system to attack the tumor and retain a long-term immune memory of the tumor in case of its reoccurrence. 

 

“To enable the treatment of ovarian cancer even at more advanced stages, we have developed implantable formulations of human lymphoid organs that could be injected at the operating table right after tumors are removed or directly inside the tumor if it cannot be removed. iNodes can then turn immunologically ‘cold tumors’ into ‘hot tumors’ by kick-starting an active anti-tumor response that sustains the fight against primary or metastatic tumors,” said Wyss Institute Senior Scientist Girija Goyal, Ph.D., who is the Principal Investigator on the iNodes project. “We are extremely excited about the ARPA-H support as it will tremendously accelerate our technology validation and translation into clinical stages and address a significant unmet need for women with ovarian cancer who lack effective treatments.”

 

Women’s health receives nine times less funding and thus suffers from a lower rate of innovation than health issues that affect men or children. Ovarian cancer in particular only receives 1% of the global investment into solid tumor R&D. ARPA-H launched the Sprint for Women’s Health to address critical unmet challenges in women’s health, champion transformative innovations, and tackle health conditions that uniquely or disproportionately affect women. The iNodes concept is supported through the Sprint’s “spark” track, which specifically focuses on early-stage research.

 

iNodes beginnings

Goyal and a team including Wyss Founding Director Donald Ingber, M.D., Ph.D., Lucas Barck, Pranav Prabhala and Sudip Paudel, Ph.D. embarked on the newly minted iNodes project in 2023. Before that the researchers had already supported their early idea to devise a method to create lymphoid organs in vitro by combining biomaterials with immune cells as a 1st year Validation Project. They demonstrated that the immune structures could activate lymphocytes and eliminate immunologically active human lung cancer cells in laboratory assays. Their findings brought Goyal and the team to the key question of whether they could create injectable lymphoid organs or nodes (iNodes) for therapeutic purposes. They successfully secured Validation Project funding for a 2nd year for this therapeutic pivot, and demonstrated that injecting human immune cells mixed with extracellular matrix proteins directly into human tumor masses in mice caused lymphoid organs to form within the tumors. 

 

“Goyal's iNode concept emerged out of her earlier work developing a Lymph Node Chip as part of our long-standing human Organ-on-a-Chip development effort. Driven by the urgent need for new therapies to treat cancers specifically affecting women, she quickly focused the team on ovarian cancer. The ARPA-H Sprint for Women’s Health came at exactly the right time and seemed a wonderful fit for advancing a new type of personalized immunotherapy for this devastating disease,” said Ingber, who is also the Judah Folkman Professor of Vascular Biology at HMS and Boston Children’s Hospital, and the Hansjörg Wyss Professor of Biologically Inspired Engineering at Harvard School of Engineering and Applied Sciences.

 

iNodes for patients

In the ARPA-H-awarded project, the team will de-risk iNodes for ovarian cancer by testing their ability to shrink tumor masses in mice carrying human ovarian tumors, and combining them with other forms of immunotherapy, including immune checkpoint therapies that by themselves have not yet shown the desired efficacy in patients with ovarian cancer but could synergize with iNodes to enhance their effects.

 

“We envision that patients with ovarian cancer could be asked to bank their immune cells ahead of surgeries through simple procedures that are available at most medical centers. iNodes can be created in a short time and injected at tumor sites where they develop into lymphoid organs in a matter of days or a few weeks, instead of the years that natural lymphoid organs can take to develop. This would enable the immune system to be instantly activated against tumors or residual tumor cells to fight recurrence,” said Goyal. 

 

Goyal is joined on the iNodes team by Sudip Paudel, Ph.D., a Postdoctoral Fellow involved in de-risking and further validating the technology; Research Technician Abdul Isaacs; Gretchen Fougere, Ph.D., the Wyss Institute’s Business Director – Healthcare, who focuses on Women’s Health; as well as Samuel Inverso, Ph.D., the Institute’s Director of Business Development – Partnerships.

 

“We believe the iNodes project has the potential to produce an effective and relatively inexpensive solution in the fight against ovarian cancer that could face far fewer hurdles than the complex manufacturing of other personalized cell therapies. It also is a shining example of how we are extending the reach of the burgeoning Women’s Health Catalyst here at the Wyss Institute,” said Ingber.

 

Media contact

 

Benjamin Boettner, Ph.D., Wyss Institute, Benjamin.Boettner@wyss.harvard.edu

 

###

 

The Wyss Institute for Biologically Inspired Engineering at Harvard University (www.wyss.harvard.edu) is a research and development engine for disruptive innovation powered by biologically-inspired engineering with visionary people at its heart. Our mission is to transform healthcare and the environment by developing ground-breaking technologies that emulate the way Nature builds and accelerate their translation into commercial products through formation of startups and corporate partnerships to bring about positive near-term impact in the world. We accomplish this by breaking down the traditional silos of academia and barriers with industry, enabling our world-leading faculty to collaborate creatively across our focus areas of diagnostics, therapeutics, medtech, and sustainability. Our consortium partners encompass the leading academic institutions and hospitals in the Boston area and throughout the world, including Harvard’s Schools of Medicine, Engineering, Arts & Sciences and Design, Beth Israel Deaconess Medical Center, Brigham and Women’s Hospital, Boston Children’s Hospital, Dana–Farber Cancer Institute, Massachusetts General Hospital, the University of Massachusetts Medical School, Spaulding Rehabilitation Hospital, Boston University, Tufts University, Charité – Universitätsmedizin Berlin, University of Zürich, and Massachusetts Institute of Technology.

 

END


[Attachments] See images for this press release:
Wyss Institute’s iNodes team receives ARPA-H Sprint for Women’s Health award to advance the first implantable immune organs to treat ovarian cancer Wyss Institute’s iNodes team receives ARPA-H Sprint for Women’s Health award to advance the first implantable immune organs to treat ovarian cancer 2

ELSE PRESS RELEASES FROM THIS DATE:

Goblet cells could be the guardians of the gut

Goblet cells could be the guardians of the gut
2024-11-12
In a recent study, researchers at the University of California, San Diego, have provided new insights into the central role of goblet cells—specialized cells that line the gut—in maintaining a healthy and balanced immune environment within the gastrointestinal (GI) tract. Led by Dr Fernanda Raya Tonetti, with Dr. Cristina Llorente directing the project and making significant contributions, the study underscores the critical roles of these cells, which act not only as a physical barrier but also ...

Romania’s science journalists join forces on new reporting handbook 

Romania’s science journalists join forces on new reporting handbook 
2024-11-12
The Balkan Network of Science Journalists and the European Federation for Science Journalism are launching a new science journalism guide, this time in Romanian.  From the Field: A Science Journalist's Handbook is the result of a collective effort by more than 20 Romanian journalists and content creators who dedicated their time and expertise to build a 138-page document designed to help journalists navigate the complex world of science reporting. The guide was coordinated by science ...

SwRI-led team proposes new solar composition ratios that could reconcile longstanding questions

SwRI-led team proposes new solar composition ratios that could reconcile longstanding questions
2024-11-12
SAN ANTONIO — November 12, 2024 — A Southwest Research Institute-led team combined compositional data of primitive bodies like Kuiper Belt objects, asteroids and comets with new solar data sets to develop a revised solar composition that potentially reconciles spectroscopy and helioseismology measurements for the first time. Helioseismology probes the Sun’s interior by analyzing the waves that travel through it, while spectroscopy reveals the surface composition based on the spectral signature produced by each chemical element.   A paper about this research, which ...

Sodium butyrate inhibits necroptosis by regulating MLKL via E2F1 in intestinal epithelial cells of liver cirrhosis

Sodium butyrate inhibits necroptosis by regulating MLKL via E2F1 in intestinal epithelial cells of liver cirrhosis
2024-11-12
Background and Aims Necroptosis is critical for regulating intestinal epithelial cells (IECs). Butyric acid (BA), produced during intestinal microbial metabolism, protects the intestinal epithelial barrier. However, whether necroptosis occurs in IECs during liver cirrhosis and whether sodium butyrate (NaB) can regulate necroptosis have not yet been reported. In this study, we aimed to investigate whether IECs undergo necroptosis in cirrhosis and whether NaB can regulate necroptosis and the related regulatory mechanisms. Methods Serum levels of RIPK3, MLKL, and Zonulin, as well as fecal BA levels, were measured and correlated in 48 patients with liver cirrhosis ...

In greening Arctic, caribou and muskoxen play key role

In greening Arctic, caribou and muskoxen play key role
2024-11-12
The story of Arctic greening has overlooked some main characters. At center stage are climate change and warming temperatures. Meanwhile, large grazing wildlife, such as caribou and muskoxen, also play a key role in the timing and abundance of Arctic plants, according to a study from the University of California, Davis. The study, published today in the journal PNAS Nexus, highlights the importance of large herbivores to the Arctic ecosystem, linking grazing with plant phenology and abundance in the Arctic tundra. Phenology is the study of the timing and cyclical patterns in nature, such as when birds migrate, or when a plant first sprouts or blooms. ...

New study confirms whole pork carcass products as high-quality protein sources across diverse cultures and preparations

New study confirms whole pork carcass products as high-quality protein sources across diverse cultures and preparations
2024-11-12
A recent study led by researchers from the University of Illinois, including Dr. Hans Stein, confirms that a wide range of pork cuts, Italian hams, and sausages offer excellent protein quality. The study, published in JSFA Reports,1 utilized the Digestible Indispensable Amino Acid Score (DIAAS) method to measure protein quality, finding that all tested pork products, except one, achieved a DIAAS greater than 100, qualifying them as "excellent" protein sources for children, adolescents, and adults.  The researchers ...

Astronomers’ theory of how galaxies formed may be upended

Astronomers’ theory of how galaxies formed may be upended
2024-11-12
CLEVELAND—The standard model for how galaxies formed in the early universe predicted that the James Webb Space Telescope (JWST) would see dim signals from small, primitive galaxies. But data are not confirming the popular hypothesis that invisible dark matter helped the earliest stars and galaxies clump together. Instead, the oldest galaxies are large and bright, in agreement with an alternate theory of gravity, according to new research from Case Western Reserve University published Tuesday November 12 in The Astrophysical Journal. The results challenge astronomers’ understanding of the early universe. “What the theory of dark matter predicted is not what we ...

Vitamin D supplements may lower blood pressure in older people with obesity

2024-11-12
WASHINGTON—Vitamin D supplements may lower blood pressure in older people with obesity and taking more than the Institutes of Medicine’s (IOM) recommended daily dose does not provide additional health benefits, according to new research published in the Journal of the Endocrine Society. The IOM recommends 600 International Units (IU) per day. Vitamin D deficiency is common worldwide and has been associated with heart disease, immunological diseases, infections and cancer. Studies have linked vitamin D deficiency to a higher risk of hypertension, but evidence for the beneficial effect of vitamin D supplementation on blood pressure outcomes ...

Climate change threatens rare temperate rainforests

2024-11-12
Up to two thirds of the world’s temperate rainforests could fall victim to climate change by the year 2100 according to a new study by researchers at the University of Leeds. In the first ever worldwide assessment of the impacts of global overheating on these rare ecosystems, scientists used maps of tree cover, forest condition, and climate data to assess how much of the world’s temperate rainforests have already been impacted by human activity and how climate change would push some regions to the brink. The results of their study which are published today (Tuesday 12 November) ...

The American Pediatric Society announces its new members for 2025

2024-11-12
The American Pediatric Society (APS) is pleased to announce ninety-eight new members. Founded in 1888, the APS is North America's first and most prestigious academic pediatric organization.  APS members are recognized child health leaders of extraordinary achievement who work together to shape the future of academic pediatrics. Current members nominate new members by recognizing individuals who have distinguished themselves as child health leaders, teachers, scholars, policymakers, and clinicians. “The Council of the APS is excited to welcome this large group of child health leaders ...

LAST 30 PRESS RELEASES:

UTokyo and NARO develop new vertical seed distribution trait for soybean breeding

Research into UK’s use of plastic packaging finds households ‘wishcycle’ rather than recycle – risking vast contamination

Vaccine shows promise against aggressive breast cancer

Adverse events affect over 1 in 3 surgery patients, US study finds

Outsourcing adult social care has contributed to England’s care crisis, argue experts

The Lancet: Over 800 million adults living with diabetes, more than half not receiving treatment, global study suggests

New therapeutic approach for severe COVID-19: faster recovery and reduction in mortality

Plugged wells and reduced injection lower induced earthquake rates in Oklahoma

Yin selected as a 2024 American Society of Agronomy Fellow

Long Covid could cost the economy billions every year

Bluetooth technology unlocks urban animal secrets

This nifty AI tool helps neurosurgeons find sneaky cancer cells

Treatment advances, predictive biomarkers stand to improve bladder cancer care

NYC's ride-hailing fee failed to ease Manhattan traffic, new NYU Tandon study reveals

Meteorite contains evidence of liquid water on Mars 742 million years ago

Self-reported screening helped reduce distressing symptoms for pediatric patients with cancer

Which risk factors are linked to having a severe stroke?

Opening borders for workers: Abe’s profound influence on Japan’s immigration regime

How skills from hospitality and tourism can propel careers beyond the industry

Research shows managers of firms handling recalls should review media scrutiny before deciding whether to lobby

New model system for the development of potential active substances used in condensate modifying drugs

How to reduce social media stress by leaning in instead of logging off

Pioneering research shows sea life will struggle to survive future global warming

In 10 seconds, an AI model detects cancerous brain tumor often missed during surgery 

Burden of RSV–associated hospitalizations in US adults, October 2016 to September 2023

Repurposing semaglutide and liraglutide for alcohol use disorder

IPK-led research team provides insights into the pangenome of barley

New route to fluorochemicals: fluorspar activated in water under mild conditions

Microbial load can influence disease associations

Three galactic “red monsters” in the early Universe

[Press-News.org] Wyss Institute’s iNodes team receives ARPA-H Sprint for Women’s Health award to advance the first implantable immune organs to treat ovarian cancer
iNodes is a new treatment paradigm in personalized immunotherapy with the potential to prolong the lives of many patients with advanced ovarian cancer