PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Global healthspan-lifespan gaps among 183 WHO member states

JAMA Network Open

2024-12-11
(Press-News.org) About The Study: This study identifies growing healthspan (years lived in good health)-lifespan gaps around the globe, threatening healthy longevity across worldwide populations. Women globally exhibited a larger healthspan-lifespan gap than men. 

Corresponding Author: To contact the corresponding author, Andre Terzic, MD, PhD, email terzic.andre@mayo.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2024.50241)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

#  #  #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.50241?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121124

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END


ELSE PRESS RELEASES FROM THIS DATE:

Stanford scientists transform ubiquitous skin bacterium into a topical vaccine

2024-12-11
Imagine a world in which a vaccine is a cream you rub onto your skin instead of a needle a health care worker pushes into your one of your muscles. Even better, it’s entirely pain-free and not followed by fever, swelling, redness or a sore arm. No standing in a long line to get it. Plus, it’s cheap. Thanks to Stanford University researchers’ domestication of a bacterial species that hangs out on the skin of close to everyone on Earth, that vision could become a reality. “We all hate needles — everybody does,” said Michael Fischbach, PhD, the Liu (Liao) Family Professor and a professor of bioengineering. “I haven’t found a single person ...

Biological diversity is not just the result of genes

Biological diversity is not just the result of genes
2024-12-11
How can we explain the morphological diversity of living organisms?  Although genetics is the answer that typically springs to mind, it is not the only explanation. By combining observations of embryonic development, advanced microscopy, and cutting-edge computer modelling, a multi-disciplinary team from the University of Geneva (UNIGE) demonstrate that the crocodile head scales emerge from the mechanics of growing tissues, rather than molecular genetics. The diversity of these head scales observed in different crocodilian species therefore arises from the evolution of mechanical parameters, such as the growth ...

Analysis reveals an additional mechanism behind statin therapy’s heart-related benefits in people with HIV

2024-12-11
Investigators who previously found that a daily statin pill helps prevent heart attacks and strokes in people with HIV have now discovered a potential mechanism that may help to stabilize plaques and prevent their rupture in blood vessels. The research led by a team from Mass General Brigham is published in JAMA Cardiology. “Individuals with HIV tend to have an excess of noncalcified plaques that are vulnerable to rupture at a younger age, putting them at high risk for strokes, heart attacks, and sudden cardiac death,” said senior author Steven Grinspoon, MD, chief of the Metabolism Unit at Massachusetts General Hospital, a founding member of the Mass General Brigham healthcare ...

Understanding how the immune system switches between rest and action

Understanding how the immune system switches between rest and action
2024-12-11
SAN FRANCISCO—Cells in the immune system don’t always fight; they often rest and wait for threats, like viruses or bacteria. When such threats emerge, the cells activate to defend the body. This delicate balance between rest and activation is crucial to our health—immune cells must be poised for activation to protect against threats, but if they’re overly active, autoimmune diseases can result. But what controls this important balance? In a new study published in Nature, scientists from Gladstone Institutes and UC San Francisco ...

Wiley expands its KnowItAll solutions with new tools for LC-MS analysis, enterprise data management, and additional spectral advances

2024-12-11
HOBOKEN, N.J.—Wiley, one of the world’s largest publishers and a global leader in research and learning, today announced the release of the new version of its KnowItAll software, with numerous advances to accelerate spectral analysis and optimize workflows. KnowItAll 2025, the latest version of Wiley’s comprehensive software suite for spectral analysis and analytical data management, introduces a groundbreaking new tool to automate LC-MS analysis, enhanced data management, and numerous other features to streamline analysis across multiple ...

A new class of antivirals could help prevent future pandemics

2024-12-11
The arrival of Paxlovid in December 2021 marked another turning point in the COVID-19 pandemic—an effective antiviral that has since successfully treated millions. But like many antivirals before it, scientists know that at some point, Paxlovid is likely to lose some efficacy due to drug resistance. Researchers working to stay ahead of such emerging threats have now identified a wholly new way to treat SARS-CoV-2 infections—work that may have even broader implications. In fact, a new study by the Tuschl ...

Nature Biotechnology | Generative chemistry enables Insilico to develop gut-restricted PhD inhibitors promising for intestinal mucosal barrier repair and immunomodulation

Nature Biotechnology | Generative chemistry enables Insilico to develop gut-restricted PhD inhibitors promising for intestinal mucosal barrier repair and immunomodulation
2024-12-11
The study presents the journey of designing and optimizing novel gut-restricted PHD inhibitors using the comprehensive generative chemistry engine Chemistry42. From initiation to preclinical candidate nomination, the program spanned only 12 months, during which approximately 115 molecules were synthesized and screened. Preclinical studies demonstrate ISM5411 to be gut-restricted and PHD-specific, thus reducing cardiovascular and systematical tumorigenic risks. Two Phase 1 clinical trials of ISM5411 for IBD are currently being conducted in parallel in Australia and China, with the last subject out in both ...

2 U-M faculty members elected to National Academy of Inventors

2024-12-11
ANN ARBOR—Two University of Michigan faculty members have been elected to the National Academy of Inventors, the highest professional distinction awarded solely to inventors. Robert Bartlett, professor emeritus of surgery at the Medical School, and Zhen Xu, professor of biomedical engineering at the College of Engineering and professor of radiology and neurosurgery at the Medical School, were elected this month to the academy. Bartlett and Xu were nominated for being innovative researchers with extensive work translating discoveries into ...

Breakthroughs in cell-penetrating monoclonal antibody therapies

Breakthroughs in cell-penetrating monoclonal antibody therapies
2024-12-11
“Monoclonal antibodies (mAb) have emerged as a promising tool in advancing personalized medicine.” BUFFALO, NY – December 11, 2024 – A news feature on the research paper “Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition” by Rackear et al. was published in Oncotarget’s Volume 15 on November 22, 2024, titled “Advancements in cell-penetrating monoclonal antibody treatment.“ This new publication by Sai Pallavi Pradeep and Raman Bahal from the  Department of Pharmaceutical Sciences at the University of Connecticut highlights significant advancements in ...

Accelerated aging in young sickle cell patients linked to elevated T-cell p16INK4a

Accelerated aging in young sickle cell patients linked to elevated T-cell p16INK4a
2024-12-11
“These initial results suggest that individuals with SCD have a significantly higher cellular senescence burden which may contribute to premature aging, physiological decline, and excess morbidities.”  BUFFALO, NY- December 11, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 21 on November 14, 2024, entitled, “Adolescents and young adults with sickle cell disease exhibit accelerated aging with elevated T-cell p16INK4a expression.” Researchers Samuel R. Wilson, Natalia Mitin, ...

LAST 30 PRESS RELEASES:

Researchers enable microorganisms to build molecules with light

Laws to keep guns away from distressed individuals reduce suicides

Study shows how local business benefits from city services

RNA therapy may be a solution for infant hydrocephalus

Global Virus Network statement on Nipah virus outbreak

A new molecular atlas of tau enables precision diagnostics and drug targeting across neurodegenerative diseases

Trends in US live births by race and ethnicity, 2016-2024

Sex and all-cause mortality in the US, 1999 to 2019

Nasal vaccine combats bird flu infection in rodents

Sepsis study IDs simple ways to save lives in Africa

“Go Red. Shop with Heart.” to save women’s lives and support heart health this February

Korea University College of Medicine successfully concludes the 2025 Lee Jong-Wook Fellowship on Infectious Disease Specialists Program

Girls are happiest at school – for good reasons

Researchers from the University of Maryland School of Medicine discover genetic ancestry is a critical component of assessing head and neck cancerous tumors

Can desert sand be used to build houses and roads?

New species of ladybird beetle discovered on Kyushu University campus

Study identifies alternate path for inflammation that could improve RA treatment

MANA scientists enable near-frictionless motion of pico- to nanoliter droplets with liquid-repellent particle coating

Chung-Ang University scientists generate electricity using Tesla turbine-inspired structure

Overcoming the solubility crisis: a solvent-free method to enhance drug bioavailability

Baby dinosaurs a common prey for Late Jurassic predators

Land-intensive carbon removal requires better siting to protect biodiversity

Devastation of island land snails, especially in the Pacific

Microwaves help turn sugar industry waste into high-performance biochar

From craft dust to green gold: Turning palm handicraft waste into high value bio based chemicals

New roadmap shows how to turn farm nitrogen models into real world water quality gains

Heart damage is common after an operation and often goes unnoticed, but patients who see a cardiologist may be less likely to die or suffer heart disease as a result

New tool exposes scale of fake research flooding cancer science

Researchers identify new blood markers that may detect early pancreatic cancer

Scientists uncover why some brain cells resist Alzheimer's disease

[Press-News.org] Global healthspan-lifespan gaps among 183 WHO member states
JAMA Network Open