(Press-News.org) A recent review is transforming the landscape of craniomaxillofacial bone regeneration with the introduction of personalized bioceramic grafts. This pioneering research explores the fabrication and clinical potential of synthetic grafts created through additive manufacturing (AM), addressing key limitations of traditional autogenous grafts. By focusing on 3D-printed bioceramics tailored to meet individual patient needs, the study marks a significant advancement in both precision medicine and patient-specific care, offering new hope for those requiring bone reconstruction.
Craniofacial bone defects, resulting from trauma, congenital conditions, or surgical interventions, represent a major challenge in reconstructive surgery. While autogenous grafts are a common solution, they are often constrained by donor site morbidity and limited availability. These drawbacks have sparked a drive to develop synthetic grafts that closely mimic the complex structure and function of natural bone. The rise of advanced bioceramic materials, combined with additive manufacturing (AM) technologies, offers a promising alternative that could revolutionize regenerative medicine and improve patient outcomes.
In a recent collaboration between researchers from the University of Michigan and São Paulo State University, a review (DOI: 10.1038/s41368-024-00327-7) published in the International Journal of Oral Science highlights the potential of AM to produce personalized bioceramic grafts. The article, released on October 31, 2024, delves into the clinical applications of these advanced materials, focusing on their role in enhancing craniomaxillofacial bone regeneration.
This detailed review examines the innovative development of 3D-printed bioceramic grafts and scaffolds for personalized bone reconstruction. It explores the critical role of ceramic-based biomaterials and the influence of graft and scaffold characteristics at both macro and micro levels. The research meticulously outlines the process of engineering customized bioceramic grafts through material extrusion-based 3D printing, supported by in vitro models to assess their effectiveness. Additionally, the study investigates the signaling pathways activated by these bioceramics when in contact with cells, highlighting their potential to foster bone growth. A key aspect of the research is the potential for these synthetic grafts to degrade in parallel with new bone tissue formation, ensuring optimal integration and long-term functionality.
“AM is revolutionizing regenerative medicine,” says lead researcher Dr. Marco C. Bottino. “Our findings demonstrate that 3D-printed bioceramic grafts provide a more precise, effective solution for craniomaxillofacial bone reconstruction. This approach not only reduces surgical site morbidity but also offers improved patient outcomes.”
The future of craniomaxillofacial bone repair looks promising with these personalized bioceramic grafts. Beyond transforming bone reconstruction, this technology has broader implications for regenerative medicine, offering a more effective and customized approach to treating a wide range of bone defects and injuries. The potential applications of this research could reshape the field, providing patients with more precise and efficient treatment options while minimizing complications.
###
References
DOI
10.1038/s41368-024-00327-7
Original Source URL
https://doi.org/10.1038/s41368-024-00327-7
Funding information
This project was supported by funding from the National Institutes of Health (NIH, National Institute of Dental and Craniofacial Research [R01DE031476 to MCB] and by the São Paulo Research Foundation (FAPESP, projects 2022/03811-9 to ABGC; 2021/05259-9 to RLMSO; and 2022/12217-3 to EST).
About International Journal of Oral Science
International Journal of Oral Science (ISSN 1674-2818) was founded in 2009 and aims to publish all aspects of oral science and interdisciplinary fields, including fundamental, applied and clinical research. Covered areas include oral microbiology, oral and maxillofacial oncology, cariology, oral inflammation and infection, dental stem cells and regenerative medicine, craniofacial surgery, dental materials, oral biomechanics, oral, dental and maxillofacial genetic and developmental diseases.
END
Custom-fit bone grafts: the future of craniomaxillofacial surgery
2024-12-31
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
A new ‘molecular lantern’ detects brain metastasis in mice by inserting a probe thinner than a hair into the brain
2024-12-31
Monitoring the changes caused in the brain at the molecular level by cancer and other neurological pathologies in a non-invasive way is one of the great challenges of biomedical research. A new technique, still in the experimental stage, achieves this by introducing light into the brains of mice using a very thin probe. The innovation, which is published today in the journal Nature Methods, is ledby an international team including groups from the Spanish National Research Council (CSIC) and the Spanish National Cancer Research ...
McGill scientist reveals how early life experiences reshape our genes and brain health
2024-12-31
MONTREAL, Quebec, Canada, 31 December 2024 - In a comprehensive Genomic Press Interview, renowned neuroscientist Dr. Michael Meaney reveals pivotal discoveries about the intricate relationship between genes and environment in shaping brain health. As a James McGill Professor Emeritus and former Director of the Translational Neuroscience program at ASTAR Singapore, Dr. Meaney's research has fundamentally altered our understanding of how early-life experiences influence genetic expression and brain development.
"I have always been genuinely fascinated ...
Renowned scientist reveals vital link between inflammation and depression through groundbreaking research
2024-12-31
JERUSALEM, Israel, 31 December 2024 - In a comprehensive Genomic Press Interview, distinguished neuroscientist Professor Raz Yirmiya unveils transformative insights into the relationship between inflammation and depression. As head of the Laboratory for Psychoneuroimmunology at the Hebrew University of Jerusalem, Professor Yirmiya's work has fundamentally changed our understanding of depression's biological underpinnings.
"Most depressed patients do not have any overt inflammatory disease. However, we and others found that exposure to stress, which is the most significant trigger of depression in humans and animals, also ...
Medical researcher explores economic impact of psychedelic therapy implementation
2024-12-31
ATLANTA, Georgia, USA, 31 December 2024 - In a comprehensive Genomic Press Interview, Emory University MD candidate Fayzan Rab shares insights into his pioneering research on the economic and public health implications of psychedelic therapy implementation. Rab's work at the Emory Center for Psychedelics and Spirituality bridges the gap between clinical research and real-world healthcare delivery systems.
"It would be a fool's errand to say that psychedelic therapies alone would change that," says Rab, discussing mental healthcare challenges. "Treating mental illness will require changes within clinical practice but also investments into social safety ...
Improving immunotherapies for kidney cancer
2024-12-30
A Medical University of South Carolina Hollings Cancer Center researcher is exploring new ways to improve treatment options for kidney cancer patients. With funding from a Department of Defense (DOD) Academy of Kidney Cancer Investigators Early Career Scholar Award, Aguirre de Cubas, Ph.D., will investigate how the immune system can be boosted to detect and kill kidney tumors. Congress established the award in 2017 to support research with high potential impact and exceptional scientific merit. De Cubas’ approach focuses on reactivating the immune system to recognize and target cancer cells better, offering new possibilities for improving existing ...
Billing patients for portal messages could decrease message volume and ease physician workload
2024-12-30
Embargoed for release until 5:00 p.m. ET on Monday 30 December 2024
@Annalsofim
Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, ...
Study of Sherpas highlights key role of kidneys in acclimatization to high altitudes
2024-12-30
(Calgary) — A study from a Mount Royal University physiologist and his team demonstrates the key role of the kidneys in acclimatization to high altitude, and illustrates another way that Sherpas are better adapted to high altitude ascent.
Results from the study were recently published in in the prestigious international science journal Proceedings of the National Academy of Sciences.
The paper, “Comparing integrative ventilatory and renal acid-base acclimatization in lowlanders and Tibetan highlanders during ascent to 4,300 m”, describes findings ...
Smartphone app can help reduce opioid use and keep patients in treatment, UT Health San Antonio study shows
2024-12-30
SAN ANTONIO, Dec. 30, 2024 – Patients with opioid use disorder can reduce their days of opioid use and stay in treatment longer when using a smartphone app as supportive therapy in combination with medication, a new study by The University of Texas Health Science Center at San Antonio (UT Health San Antonio) shows.
The cohort study of 600 underserved patients found that those who chose to use the app – which combines contingency management behavioral therapy and recovery support from peers – and alongside medication, reduced their days of opioid use by 35% compared with ...
Improved health care value cannot be achieved by hospital mergers and acquisitions alone
2024-12-30
Key Takeaways
A new study finds little evidence that hospital mergers and acquisitions reduce costs or improve quality of care.
More strategic quality improvement efforts are needed for patients to benefit from health care integration.
CHICAGO (December 30, 2024) — Mergers and acquisitions of U.S. hospitals and health systems rarely improve the quality of care delivered or result in lower health care costs and prices, according to a study published in the Journal of the American College of Surgeons (JACS).
The study, a systematic review of hundreds of published ...
People who are immunocompromised may not produce enough protective antibodies against RSV after vaccination
2024-12-30
FOR IMMEDIATE RELEASE
Johns Hopkins Medicine researchers have shown that people 60 years or older with weakened immunity — primarily organ transplant recipients who take immunosuppressive medications to reduce the risk of rejection and others with immune system disorders — do not respond as strongly to vaccines against the respiratory syncytial virus (RSV) as people in the same age group with normal immune function.
The study, conducted by a research team at the Johns Hopkins Transplant Research Center, was published today in the Journal of the American ...