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New findings may help researchers develop a grapefruit devoid of compounds that affect medication levels

2025-01-08
(Press-News.org) Grapefruit and pummelo contain compounds called furanocoumarins that may affect the blood levels of more than 100 prescription drugs, so that people taking these medications are advised to remove these fruits from their diets. Research published in New Phytologist reveals genetic information about the synthesis of furanocoumarins in different citrus plant tissues and species and provides new insights that could be used to develop grapefruit and pummelo that lack furanocoumarins.

The research indicates that the production of furanocoumarins in citrus fruit is dependent on the integrity of a single gene within a multi-gene cluster that encodes enzymes of the 2-oxoglutarate-dependent dioxygenase family.

“This research helps us to understand why fruit of certain citrus species produce furanocoumarins and demonstrates how breeders and researchers could develop furanocoumarin-free citrus varieties,” said co–corresponding author Yoram Eyal, PhD, of the Volcani Center, in Israel.

URL upon publication: https://onlinelibrary.wiley.com/doi/10.1111/nph.20322

 

Additional Information
NOTE: The information contained in this release is protected by copyright. Please include journal attribution in all coverage. For more information or to obtain a PDF of any study, please contact: Sara Henning-Stout, newsroom@wiley.com.

About the Journal
New Phytologist is an international journal publishing outstanding original research in plant science and its applications. Research falls into five sections: Physiology & Development, Environment, Interaction, Evolution, and Transformative Plant Biotechnology. Topics covered range from intracellular processes through to global environmental change. New Phytologist is owned by the New Phytologist Foundation, a non-profit organization dedicated to the promotion of plant science.

About Wiley      
Wiley is one of the world’s largest publishers and a trusted leader in research and learning. Our industry-leading content, services, platforms, and knowledge networks are tailored to meet the evolving needs of our customers and partners, including researchers, students, instructors, professionals, institutions, and corporations. We empower knowledge-seekers to transform today’s biggest obstacles into tomorrow’s brightest opportunities. For more than two centuries, Wiley has been delivering on its timeless mission to unlock human potential. Visit us at Wiley.com. Follow us on Facebook, X, LinkedIn and Instagram.

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[Press-News.org] New findings may help researchers develop a grapefruit devoid of compounds that affect medication levels