Development and validation of a tool to predict onset of mild cognitive impairment and Alzheimer dementia

JAMA Network Open

2025-01-08

(Press-News.org) About The Study: In this prognostic study, with the use of a statistical modeling approach, the Florey Dementia Index was developed and validated to predict the onset age of mild cognitive impairment and Alzheimer dementia. This tool may be useful in organizing health care for older adults with cognitive decline or dementia and in the future may help prioritize patients for the use of disease-modifying monoclonal antibody drugs.

Corresponding Authors: To contact the corresponding authors, email Yijun Pan, PhD (yijun.pan@unimelb.edu.au) and Liang Jin, PhD (liang.jin@unimelb.edu.au).

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2024.53756)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.53756?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=010825

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

New AI predicts inner workings of cells

2025-01-08

NEW YORK, NY (Jan. 8, 2025)--Using a new artificial intelligence method, researchers at Columbia University Vagelos College of Physicians and Surgeons can accurately predict the activity of genes within any human cell, essentially revealing the cell’s inner mechanisms. The system, described in the current issue of Nature, could transform the way scientists work to understand everything from cancer to genetic diseases. “Predictive generalizable computational models allow to uncover biological ...

Scientists uncover key step in how diazotrophs “fix” nitrogen

2025-01-08

Nitrogen is an essential component in the production of amino acids and nucleic acids — both necessary for cell growth and function. Although the atmosphere is composed of nearly 80% nitrogen, this nitrogen is in the form of dinitrogen (N2), which cannot be processed by most organisms. Atmospheric nitrogen must first be converted, or “fixed,” into a form that can be used by plants, often as ammonia. There are only two ways of fixing nitrogen, one industrial and one biological. To better understand a key component of the biological process, University of California San Diego Professor of Chemistry and Biochemistry Akif Tezcan and Assistant Professor of Chemistry ...

The hidden mechanics of earthquake ignition

2025-01-08

A new study has unravelled the hidden mechanics of how earthquakes ignite, shedding light on the mysterious transition from quiet, creeping motion to the violent ruptures that shake the Earth. Using cutting-edge experiments and innovative models, the research reveals that slow, silent stress release is a prelude and a necessary trigger for seismic activity. By incorporating the overlooked role of fault geometry, the study challenges long-held beliefs and offers a fresh perspective on how and when earthquakes begin. These findings not only deepen our understanding of nature’s ...

Scientists leverage artificial intelligence to fast-track methane mitigation strategies in animal agriculture

2025-01-08

BUSHLAND, Texas, Jan. 8, 2025 –A new study from USDA’s Agricultural Research Service (ARS) and Iowa State University (ISU) reveals that generative Artificial Intelligence (AI) can help expedite the search for solutions to reduce enteric methane emissions caused by cows in animal agriculture, which accounts for about 33 percent of U.S. agriculture and 3 percent of total U.S. greenhouse gas emissions. "Developing solutions to address methane emissions from animal agriculture is a critical priority. Our scientists continue to use innovative and data-driven strategies to help ...

Researchers unravel a novel mechanism regulating gene expression in the brain that could guide solutions to circadian and other disorders

2025-01-08

A collaborative effort between Mount Sinai and Memorial Sloan Kettering Cancer Center has shed valuable light on how monoamine neurotransmitters such as serotonin, dopamine, and now histamine help regulate brain physiology and behavior through chemical bonding of these monoamines to histone proteins, the core DNA-packaging proteins of our cells. By uncovering how these histone modifications influence the brain, the team has identified a novel mechanism for controlling circadian gene expression and behavioral rhythms. ...

Discovery of 'Punk' and 'Emo' fossils challenges our understanding of ancient molluscs

2025-01-08

Researchers have unearthed two fossils, named Punk and Emo, revealing that ancient molluscs were more complex and adaptable than previously known. Molluscs are one of life’s most diverse animal groups and analysis of the rare 430 million year old fossils is challenging long-held views on their early origins. The fossils dating from the Silurian period were retrieved from Herefordshire and shed light on the molluscs’ complex evolutionary history and how they moved. The discovery challenges the longstanding ...

Exposure to aircraft noise linked to worse heart function

2025-01-08

People who live close to airports and are exposed to high aircraft noise levels could be at greater risk of poor heart function, increasing the likelihood of heart attacks, life-threatening heart rhythms and strokes, according to a new study led by UCL (University College London) researchers. The study, published in the Journal of the American College of Cardiology (JACC), looked at detailed heart imaging data from 3,635 people who lived close to four major airports in England. Within this group, the research team compared the hearts of those who lived in areas with higher aircraft noise with those who lived in lower aircraft noise areas. They found that those who lived in ...

Deans of the University of Nottingham visited Korea University's College of Medicine

2025-01-08

Deans of the University of Nottingham Visited Korea University's College of Medicine Korea University's College of Medicine Dean, Sung Bom Pyun, and Deans of the University of Nottingham; successfully held a researcher meeting program for 2 days from November 11th to 12th. Fuve representative deans visited the University of Korea: Professor Claire Stewart, the Dean and Head of the School of Medicine at the University of Nottingham; Professor Nigel Mongan, Professor Alan McIntyre, Professor Srinivasan Madhusudan, and Professor Victoria James. They joined the program to conduct a tour and meeting with Korea University's researchers. On ...

New study assesses wildfire risk from standing dead trees in Yellowstone National Park

2025-01-08

Standing dead trees in Yellowstone National Park are growing wildfire hazards, especially near park infrastructure. A new study published in Forest Ecosystems explores how these dead trees contribute to fire risk and threaten roads, buildings, and trails. Dead trees, particularly those that remain standing, are a significant fire hazard. These trees—often caused by pests, diseases, and climate change—create a large amount of dry, combustible material. As temperatures rise and droughts intensify, the risk of wildfires increases, making it essential to understand how dead trees contribute to fire danger. The team used a random forest classification model, a powerful ...

A new approach for improving hot corrosion resistance and anti-oxidation performance in silicide coating on niobium alloys

2025-01-08

The widely used nickel-based superalloys for turbine engine materials showed a limited-service temperature of only 1200℃, and did not exceed 1500℃ even when coated with thermal barrier coatings, which is urgent to develop the advanced thermal protection system for turbine engines with higher thrust-weight ratios. Niobium alloy coated with silicide coating is undoubtedly considered the most efficient method to reach long-term service, since it can form a dense SiO2 layer with self-healing ability at high temperatures. However, the single silicide coating has a strong tendency to crack vertically ...

Development and validation of a tool to predict onset of mild cognitive impairment and Alzheimer dementia

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: