First evidence of olaparib maintenance therapy in patients with newly diagnosed homologous recombination deficient positive/BRCA wild-type ovarian cancer: real-world multicenter study
2025-01-23
(Press-News.org)
Ovarian cancer, a deadly gynecologic malignancy, has seen a significant shift in its treatment paradigm with the introduction of poly (ADP-ribose) polymerase (PARP) inhibitors, which are now standard in the maintenance setting following first-line chemotherapy. This retrospective cohort study investigates the real-world effectiveness and safety of olaparib, a PARP inhibitor, in patients with newly diagnosed advanced-stage, high-grade serous ovarian cancer who are HRD positive but BRCA wild-type, a demographic less extensively explored in previous research. The primary goal was to assess the 1-year progression-free survival (PFS) rate of olaparib maintenance therapy in this specific patient group, offering insights into its potential as a therapeutic option.
Conducted across 11 high-volume tertiary care centers in China, the study included patients who received olaparib as frontline maintenance therapy after achieving a complete or partial response to platinum-based chemotherapy. The analysis focused on the 1-year PFS rate, median PFS, time to first subsequent therapy or death, and treatment-related adverse events. The 1-year PFS rate was 75.2%, with a median PFS of 21.0 months, aligning with previous trials and highlighting olaparib's efficacy in maintaining remission in patients with HRD-positive, BRCA wild-type ovarian cancer. The safety profile of olaparib was consistent with known adverse events, primarily anemia and nausea, with most patients continuing treatment without discontinuation due to these events.
The findings from this study are significant as they provide the first evidence supporting the use of olaparib in patients with newly diagnosed HRD-positive/BRCA wild-type ovarian cancer, a population that has been less studied in the context of PARP inhibitor efficacy. This fills a gap in the research and provides new therapeutic options for clinical treatment. Despite the study's limitations, including its retrospective design, short follow-up period, and small sample size, the results are still enlightening and require further validation through the ongoing phase III MONO-OLA1 study. Overall, this study underscores the importance of PARP inhibitors in the treatment of newly diagnosed ovarian cancer and offers a potential effective treatment option for HRD-positive/BRCA wild-type patients.
DOI: 10.1007/s11684-024-1083-5
END
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
2025-01-23
Camel milk udderly good alterative to traditional dairy
In addition to being hypoallergenic, camel milk could potentially protect the gut from harmful enzymes and create healthier digestion.
New research from Edith Cowan University (ECU) has found that camel milk contained more naturally occurring bioactive peptides when compared to its bovine counterpart.
“This is a good thing. We now know that camel milk has the potential to be hypoallergenic compared to cow’s milk, but also that it has higher potential to yield bioactive peptides which can have antimicrobial ...
2025-01-23
We humans excel at generalization. If you taught a toddler to identify the color red by showing her a red ball, a red truck and a red rose, she will most likely correctly identify the color of a tomato, even if it is the first time she sees one.
An important milestone in learning to generalize is compositionality: the ability to compose and decompose a whole into reusable parts, like the redness of an object. How we get this ability is a key question in developmental neuroscience – and in AI research.
The earliest ...
2025-01-23
Game, set, match: Exploring the experiences of women coaches in tennis
As the Australian Open continues in full swing, a new study can reveal female tennis coaches experience significantly more barriers in their profession – including discrimination and marginalisation – than their male counterparts, with fewer than half seeing themselves continuing as coaches long term.
Led by Dr Jasmine Petersen from Flinders University’s Caring Futures Institute, the study interviewed 243 Australian tennis coaches, a third of which were women, assessing their motivation and barriers towards coaching and the support they received.
“Women coaches continue ...
2025-01-23
There was a 65% increase in the number of children and young people being admitted to general acute medical wards in hospitals in England because of a mental health concern between 2012 and 2022, finds a new study led by UCL researchers.
The study, published in The Lancet Child and Adolescent Health journal and funded by the National Institute for Health and Care Research (NIHR) and the NIHR Great Ormond Street Hospital Biomedical Research Centre (NIHR GOSH BRC), analysed data on all admissions of five- to 18-year-olds to medical wards in England from April 1st 2012 to March 31st 2022.
General acute medical wards are specialised hospital wards designed to provide rapid ...
2025-01-23
A new study published in The BMJ suggests that prehabilitation (also called prehab) may be able to reduce complications and length of hospitalization after surgery, while also improving quality of life and physical recovery. The systematic review and meta-analysis, which is the largest of its kind, examined data from more than 15,000 patients who participated in 186 randomized controlled clinical trials around the world.
The researchers looked at various kinds of prehab, including exercise, nutritional enhancement, psychological support, cognitive ...
2025-01-23
Actively preparing for major surgery by exercising and improving diet (known as “prehabilitation”) is associated with fewer complications, less time in hospital, and improved recovery and quality of life in adults, finds an analysis of clinical trials published by The BMJ today.
The researchers stress that the certainty of evidence for all comparisons was generally low to very low, but they say prehabilitation based on exercise, nutrition, or exercise combined with other components, may be beneficial.
Existing evidence suggests that prehabilitation can improve outcomes after surgery, but there’s a lack of clarity about which components, ...
2025-01-23
Adults with overweight or obesity and type 2 diabetes who are given the sodium glucose cotransporter 2 (SGLT-2) inhibitor drug dapagliflozin alongside moderate calorie restriction achieve much higher rates of remission compared with calorie restriction alone, finds a trial published by The BMJ today.
The researchers say this study provides a practical strategy to achieve remission for patients with early type 2 diabetes.
Type 2 diabetes affects over 400 million adults worldwide. It’s not necessarily a permanent condition and can be reversed by intensive weight management, ...
2025-01-23
Gather around, and let Susan Hough tell you the tale of the Summerville Light.
Legend has it that the strange orb sometimes seen hovering over the railroad tracks in the remote area around Summerville, South Carolina is a lantern borne by a ghost whose husband lost his head in a train accident.
But Hough, a seismologist at the U.S. Geological Survey, wonders if there might be a less ethereal but no less intriguing possibility: is the source of the Summerville Light a phenomenon known as earthquake ...
2025-01-22
(SACRAMENTO) — Nearly a quarter of adults in the U.S. have chronic pain, but a new study from the UC Davis School of Medicine shows a concerning drop in residents applying to pain medicine fellowship programs.
The study was published in PAIN Practice. It found the number of anesthesiology residents applying for pain medicine fellowships — historically the key pool of applicants — dropped 45% between 2019 and 2023.
“While the demand for pain specialists is growing in the U.S., the pipeline of new doctors to fill these roles is drying up,” said Scott Pritzlaff, the study’s ...
2025-01-22
Key takeaways
The team used the environmental circumstances and fecal samples collected from the six years prior to the El Niño drought to study the relationship between the endocrinologic stress response and survival in the white-faced capuchins.
Monkeys who showed a steeper rise in these stress hormones during the mild droughts were more likely to survive the severe El Niño drought.
As weather intensifies globally, longitudinal studies of how wild animals cope with changes in temperature, rainfall and food availability can help us understand which species ...
LAST 30 PRESS RELEASES:
[Press-News.org] First evidence of olaparib maintenance therapy in patients with newly diagnosed homologous recombination deficient positive/BRCA wild-type ovarian cancer: real-world multicenter study
