Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists among us adults with overweight or obesity

JAMA Network Open

2025-01-31

(Press-News.org) About The Study: In this cohort study, most patients with overweight or obesity discontinued glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy within 1 year, but those without type 2 diabetes had higher discontinuation rates and lower reinitiation rates. Inequities in access and adherence to effective treatments have the potential to exacerbate disparities in obesity.

Corresponding Author: To contact the corresponding author, Ezekiel J. Emanuel, MD, PhD, email zemanuel@upenn.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2024.57349)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists among us adults with overweight or obesity

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