Postoperative weight loss after anti-obesity medications and revision risk after joint replacement

JAMA Network Open

2025-02-21

(Press-News.org) About The Study: In this cohort study using a target trial emulation, a higher proportion of weight loss after initiating anti-obesity medications within 1 year was associated with a lower risk of 5-year and 10-year revision among patients with obesity undergoing joint replacement. These results suggest that anti-obesity medication use, with relatively safe and sustainable weight loss, may be an effective strategy for improving implant survivorship of hip and knee replacements in the obese population.

Corresponding Author: To contact the corresponding authors, email Chao Zeng, MD, PhD (zengchao@csu.edu.cn) and Guanghua Lei, MD, PhD (lei_guanghua@csu.edu.cn).

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2024.61200)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.61200?guestAccessKey=c0957767-f5eb-4d6d-88a4-15c747418b57&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=022125

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

New ACS research finds low uptake of supportive care at the end-of-life for patients with advanced cancer

2025-02-21

Despite considerable efforts to improve the quality of end-of-life care in the United States, a new retrospective study led by American Cancer Society (ACS) researchers revealed that close to half of patients with advanced cancer received potentially aggressive care at the end-of-life at the expense of supportive care. The findings are out today in the Journal of the American Medical Association (JAMA) Health Forum. “Even though clinicians and professional healthcare organizations have recommended early integration of supportive and ...

New frailty measurement tool could help identify vulnerable older adults in epic

2025-02-21

Investigators at Mass General Brigham have developed a tool that can identify older adults at increased risk of emergency healthcare needs, rehospitalization or death. The tool measured patient frailty, an aging-related syndrome, by integrating the health records of more than 500,000 individuals collected across multiple hospitals at Mass General Brigham. These findings, published in Journal of the American Geriatric Society, could help clinicians care for high-risk patients even without the availability of comprehensive primary care records. “Frailty ...

Co-prescribed stimulants, opioids linked to higher opioid doses

2025-02-21

COLUMBUS, Ohio – The combination of prescribed central nervous system stimulants, such as drugs that relieve ADHD symptoms, with prescribed opioid medications is associated with a pattern of escalating opioid intake, a new study has found. The analysis of health insurance claims data from almost 3 million U.S. patients investigated prescribed stimulants’ impact on prescription opioid use over 10 years, looking for origins of the so-called “twin epidemic” of combining the two classes of drugs, which can increase the risk for overdose deaths. “Combining the two drugs is associated ...

What if we could revive waste carbon dioxide?

2025-02-21

As the severity of climate change and carbon emissions becomes a global concern, technologies to convert carbon dioxide (CO₂) into resources such as chemical fuels and compounds are urgently needed. Dr. Dahee Park’s research team from the Nano Materials Research Division at the Korea Institute of Materials Science (KIMS), has collaborated with Professor Jeong-Young Park’s team from the Department of Chemistry at KAIST to develop a catalyst technology that significantly enhances the efficiency of carbon dioxide (CO2) conversion. Conventional ...

Mechanochemistry strikes again – A facile means for generating organolithium molecules

2025-02-21

Mechanochemistry using a ball mill demonstrates versatility for generating academically and industrially significant organolithium compounds. Organolithium compounds, molecules containing a carbon–lithium bond, are excellent precursors for building new carbon–carbon and other carbon–heteroatom bonds. They are widely utilized in both academia and industry for their applications in polymer synthesis, pharmaceuticals, and general organic synthesis. A conventional method for generating organolithiums is done ...

Breakthrough in high-performance oxide-ion conductors using rubidium

2025-02-21

Rubidium could be the next key player in oxide-ion conductors. Researchers at Institute of Science Tokyo have discovered a rare rubidium (Rb)-containing oxide-ion conductor, Rb₅BiMo₄O₁₆, with exceptionally high conductivity. Identified through computational screening and experiments, its superior performance stems from low activation energy and structural features like large free volume and tetrahedral motion. Its stability under various conditions offers a promising direction for solid oxide fuel cells and clean energy technologies. Oxide-ion ...

Hurricane-proofed downtown skyscrapers unexpectedly vulnerable to ‘bouncing’ winds

2025-02-21

Houston, we have a problem. The ‘Space City’ boasts 50 buildings over 150 meters tall. These were designed to withstand hurricanes, to which Texas is prone. But on May 16th, 2024, a derecho – a wide, long-lived windstorm associated with rapidly moving showers or thunderstorms – managed to cause unexpected damage to many of the tall buildings downtown. The socio-economic impact was significant, due to traffic disruptions, businesses temporarily closing, and the need for repairs. Why ...

Microcomb chips help pave the way for thousand times more accurate GPS systems

2025-02-21

Optical atomic clocks can increase the precision of time and geographic position a thousandfold in our mobile phones, computers, and GPS systems. However, they are currently too large and complex to be widely used in society. Now, a research team from Purdue University, USA, and Chalmers University of Technology, Sweden, has developed a technology that, with the help of on-chip microcombs, could make ultra-precise optical atomic clock systems significantly smaller and more accessible – with significant benefits for navigation, autonomous vehicles, and geo-data monitoring. Today, our mobile phones, computers, ...

Illuminating the proton’s inner workings

2025-02-21

Scientists have now mapped the forces acting inside a proton, showing in unprecedented detail how quarks—the tiny particles within—respond when hit by high-energy photons. The international team includes experts from the University of Adelaide who are exploring the structure of sub-atomic matter to try and provide further insight into the forces that underpin the natural world. “We have used a powerful computational technique called lattice quantum chromodynamics to map the forces acting inside ...

Genetic therapy gives infants life-changing improvements in sight

2025-02-21

Four young children have gained life-changing improvements in sight following treatment with a pioneering new genetic medicine through UCL Institute of Ophthalmology and Moorfields Eye Hospital, with the support of MeiraGTx. The children were born with a severe impairment to their sight due to a rare genetic deficiency that affects the AIPL1 gene. The condition, a form of retinal dystrophy, means those affected are born with only sufficient sight to distinguish between light and darkness. The gene defect causes ...

Inhibition of cyclooxygenase-2 upregulates the nuclear factor erythroid 2-related factor 2 signaling pathway to mitigate hepatocyte ferroptosis in chronic liver injury

Postoperative weight loss after anti-obesity medications and revision risk after joint replacement

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: