Postoperative weight loss after anti-obesity medications and revision risk after joint replacement

JAMA Network Open

2025-02-21

(Press-News.org) About The Study: In this cohort study using a target trial emulation, a higher proportion of weight loss after initiating anti-obesity medications within 1 year was associated with a lower risk of 5-year and 10-year revision among patients with obesity undergoing joint replacement. These results suggest that anti-obesity medication use, with relatively safe and sustainable weight loss, may be an effective strategy for improving implant survivorship of hip and knee replacements in the obese population.

Corresponding Author: To contact the corresponding authors, email Chao Zeng, MD, PhD (zengchao@csu.edu.cn) and Guanghua Lei, MD, PhD (lei_guanghua@csu.edu.cn).

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(doi:10.1001/jamanetworkopen.2024.61200)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Postoperative weight loss after anti-obesity medications and revision risk after joint replacement

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