Characterization of research grant terminations at the National Institutes of Health

JAMA

2025-05-08

(Press-News.org) About The Study: Between February 28, 2025, and April 8, 2025, 694 National Institutes of Health (NIH) grants were terminated across 24 of the 26 institutes and centers (including the Office of the Director) that administered active NIH grants. Targeted grant terminations have affected more than $1.8 billion in NIH funding. Terminations were spread across nearly all NIH institutes and centers, although cuts disproportionately impacted the National Institute on Minority Health and Health Disparities (30% of all funding).

Corresponding Author: To contact the corresponding author, Harlan M. Krumholz, MD, SM, email harlan.krumholz@yale.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2025.7707)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.7707?guestAccessKey=3a432109-6c9d-4ef2-9d10-bf48d91fe441&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=050825

END

ELSE PRESS RELEASES FROM THIS DATE:

New study: high efficiency of severe thalassemia prevention with HTS based carrier screening

2025-05-08

Sulfur applied to sugarcane crops in South Florida is flowing into wetlands upgradient of Everglades National Park, triggering a chemical reaction that converts mercury into toxic methylmercury, which accumulates in fish, new research from University of California, Davis finds. In a paper published in Nature Communications, researchers collected water and mosquito fish across wetlands fed by agricultural canals. They documented how sulfur runoff can dramatically increase methylmercury concentrations in fish — sometimes up to 10 million times greater than the waters in which they lived, posing a risk ...

AI-designed DNA controls genes in healthy mammalian cells for first time

2025-05-08

A study published today in the journal Cell marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. Researchers at the Centre for Genomic Regulation (CRG) created an AI tool which dreams up DNA regulatory sequences not seen before in nature. The model can be told to create synthetic fragments of DNA with custom criteria, for example: ‘switch this gene on in stem cells which will turn into red-blood-cells but not platelets.’ The model then predicts which combination of DNA letters (A, T, C, G) are needed for the gene expression patterns required in specific types of cells. Researchers ...

Veterans with depression have increased risk of heart failure: Study

2025-05-08

U.S. veterans with depression had a 14% higher risk of heart failure, a new Vanderbilt University Medical Center-led study found, even after adjusting for traditional risk factors. The study, “Depression and Heart Failure in U.S. Veterans,” was published May 8 in the journal JAMA Network Open. Corresponding author Evan Brittain, MD, MSCI, professor of Medicine, said the study suggests implications for patient care. “Patients and clinicians have another reason to screen for and treat depression in order to prevent potential future heart failure,” he said. Brittain, who holds the Cardiology Division Directorship, noted the study is the largest ...

Maternal cardiometabolic risk factors in pregnancy and offspring blood pressure at ages 2 to 18

2025-05-08

About The Study: In this cohort study of 12,480 mother-offspring pairs, researchers found that pre-pregnancy obesity, gestational diabetes, and hypertensive disorders of pregnancy, alone or in various combinations, were prospectively associated with higher offspring blood pressure at an early age and with an increased rate of blood pressure change from age 2 to 18 years, with the most profound associations with diastolic blood pressure among female offspring and with systolic blood pressure among Black offspring. These findings suggest that ...

Depression and heart failure in US veterans

2025-05-08

About The Study: In this cohort study, depression among veterans was associated with an increased hazard of incident heart failure after controlling for demographic and cardiovascular risk factors. Higher incident heart failure rates in patients with depression remained consistent in an otherwise low-risk cohort. Corresponding Author: To contact the corresponding author, Evan L. Brittain, MD, MSc, email evan.brittain@vumc.org. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.9246) Editor’s Note: Please see the article for additional information, ...

Experiences of care and gaslighting in patients with vulvovaginal disorders

2025-05-08

About The Study: In this cross-sectional study, a patient-centered measure of adverse experiences in vulvovaginal care was developed. Participants reported common past experiences with gaslighting (a patient’s concerns are dismissed without proper evaluation) and substantial distress; they frequently considered ceasing care. There is an urgent need for education supporting a biopsychosocial, trauma-informed approach to vulvovaginal pain and continued development of validated instruments to quantify patient experiences. Corresponding Author: To ...

Vitamin supplements slow down the progression of glaucoma

2025-05-08

A vitamin supplement that improves metabolism in the eye appears to slow down damage to the optic nerve in glaucoma. Promising results have been published in the journal Cell Reports Medicine. The researchers behind the study have now started a clinical trial on patients. In glaucoma, the optic nerve is gradually damaged, leading to vision loss and, in the worst cases, blindness. High pressure in the eye drives the disease, and eye drops, laser treatment or surgery are therefore used to lower the pressure in the eye and thus slow down the disease. Unfortunately, however, the effect ...

Physics: Eggs less likely to crack when dropped side-on

2025-05-08

Eggs are less likely to crack when dropped on their side than when dropped vertically, finds research published in Communications Physics. Controlled trials simulating the ‘egg drop challenge’, a common classroom science experiment, found that the shell of an egg can better withstand an impact when dropped side-on. The goal of the ‘egg drop challenge’ is for students to prevent an egg from cracking when dropped from a set height. A common belief is that an egg is stronger and less likely to crack when dropped vertically, with this assumption often ...

Study links maternal health risks during pregnancy to higher blood pressure in children

2025-05-08

Children born to mothers with obesity, gestational diabetes mellitus or a hypertensive disorder of pregnancy have higher systolic and diastolic blood pressure than children born to mothers without these risk factors, according to a new USC study. Among children whose mothers had at least one risk factor, blood pressure also rose more quickly between ages 2 and 18 compared to their peers. The findings, which suggest that blood pressure interventions could start as early as pregnancy, were just published in JAMA Network Open. Across the ...

Building vaccines for future versions of a virus

2025-05-08

At a glance: Researchers have created an AI tool called EVE-Vax that can predict and design viral proteins likely to emerge in the future. For SARS-CoV-2, panels of these “designer” proteins triggered similar immune responses as real-life viral proteins that emerged during the pandemic. EVE-Vax could give scientists valuable clues to help them develop vaccines that protect against future versions of rapidly evolving viruses. Effective vaccines dramatically changed the course of the COVID-19 pandemic, preventing illness, reducing disease severity, and saving millions of ...

Characterization of research grant terminations at the National Institutes of Health

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: