First-trimester mRNA COVID-19 vaccination and risk of major congenital anomalies

JAMA Network Open

2025-10-15

(Press-News.org) About The Study: In this cohort study of pregnancies exposed to messenger RNA (mRNA) COVID-19 vaccines in the first trimester, exposure was not associated with an increased risk of any major congenital malformations, overall, by organ group, or by individual major congenital malformation, supporting the safety of mRNA COVID-19 vaccines in early pregnancy.

Corresponding Authors: To contact the corresponding authors, email Clement Bernard, MSc (clement.bernard@ansm.sante.fr) and Mahmoud Zureik, MD, PhD (mahmoud.zureik@ansm.sante.fr).

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.38039)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.38039?guestAccessKey=1b34668e-afe8-4888-aa3d-dd05b3b83eff&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=101525

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Glucose-lowering medication classes and cardiovascular outcomes in patients with type 2 diabetes

2025-10-15

About The Study: In this study, major adverse cardiovascular event risk varied significantly by medication class, with most protection achieved with sustained treatment with glucagon-like peptide-1 receptor agonists (GLP-1RAs) followed by sodium-glucose cotransporter-2 inhibitors (SGLT2is), sulfonylureas, and dipeptidyl peptidase-4 inhibitors. The magnitude of benefit of GLP-1RAs over SGLT2is depended on baseline age, atherosclerotic cardiovascular disease, heart failure, and kidney impairment. These results, along with consideration of cost, availability, and ...

Rising seas and sinking cities signal a coastal crisis in China

2025-10-15

A team of scientists led by Rutgers researchers has uncovered evidence that modern sea level rise is happening faster than at any time in the past 4,000 years, with China’s coastal cities especially at risk. The scientists examined thousands of geological records from a number of sources, including ancient coral reefs and mangroves, which serve as natural archives of past sea levels. They reconstructed sea level changes going back nearly 12,000 years, which marks the beginning of the current geological epoch, the Holocene, which followed the last major ice age. Reporting in Nature, their findings show that since 1900, global ...

Discovery of hundreds of new human gut viruses provides a new approach to studying the gut microbiome

2025-10-15

Hundreds of new viruses living inside bacteria within our gut have been discovered in an international study led by Professor Jeremy J. Barr from Monash University’s School of Biological Sciences and Associate Professor Sam Forster from Hudson Institute of Medical Research. These viruses, known as bacteriophages, could eventually be used to reshape the gut microbiome, potentially influencing gut health and the progression of various disease states. Published in Nature, the study is the first of its kind and uses a large-scale, culture-based approach to isolate and ...

Study indicates dramatic increase in percentage of US adults who meet new definition of obesity

2025-10-15

The prevalence of obesity in the United States could rise sharply under a new definition of obesity released earlier this year by the Lancet Diabetes and Endocrinology Commission. Researchers from Mass General Brigham found that when applying the new criteria, which expands upon the traditional use of body mass index (BMI) to include measures of body fat distribution, the prevalence of obesity increased from about 40 percent to about 70 percent among over 300,000 people included in their study. The rise was even more pronounced ...

Astrocytes are superstars in the game of long-term memory

2025-10-15

Why are we able to recall only some of our past experiences? A new study led by Jun Nagai at the RIKEN Center for Brain Science in Japan has an answer. Surprisingly, it turns out that the brain cells responsible for stabilizing memories aren’t neurons. Rather, they are astrocytes, a type of glial cell that is usually thought of as a role player in the game of learning and memory. Published in the scientific journal Nature on Oct 15, the study shows how emotionally intense experiences like fear biologically ...

WSU study finds positive framing can steer shoppers toward premium products

2025-10-15

PULLMAN, Wash. -- Consumers are more likely to choose a higher-priced item when it’s correlated with messages that emphasize an increase in the product’s positive attributes—rather than a reduction in its negative ones. When deciding between two products, consumers don’t just compare costs, they also respond to how the relationship between the cost and product attributes is described. A new Washington State University study shows that people perceive a stronger link between price and product attributes when the relationship is ...

Study finds ending universal free school meals linked to rising student meal debt and stigma

2025-10-15

October 15, 2025 – A new study published in the Journal of Nutrition Education and Behavior, published by Elsevier, found that discontinuing universal free school meal (UFSM) policies significantly increases school meal debt, student stigma, and declines in participation. The research, based on a survey of nearly 1,000 school food authorities (SFAs) across eight states, also found that states continuing UFSM through state-level policies reported more stable revenues and greater student access to nutritious meals. Researchers conducted a cross-sectional survey in the spring of 2023 with 941 SFAs from states that either ...

Innovations in organoid engineering: Construction methods, model development, and clinical translation

2025-10-15

As a revolutionary 3D cell culture system, organoids bridge the gap between traditional 2D models and animal studies. This review synthesizes the current state of organoid engineering, from fundamental methods to transformative applications. Organoid Construction Key methods enable the generation of complex organoids: Air-Liquid Interface (ALI) Culture: Ideal for modeling hollow organs and co-culturing with immune cells to study the tumor microenvironment. Bioreactor Culture: Uses agitation to enhance nutrient exchange, supporting ...

Rescheduling coca: Aligning global drug policy with science, tradition, and indigenous rights

2025-10-15

In a Policy Forum, Dawson White and colleagues argue that international drug policy must distinguish between the coca leaf – a sacred plant long cultivated in South America – and its purified chemical derivative, cocaine. The World Health Organization’s Expert Committee on Drug Dependence (ECDD) is now reassessing the plant’s status, which, according to the authors, presents a rare opportunity to realign global drug policy with scientific evidence and Indigenous rights. Currently, the coca bush is classified under international law as a Schedule I drug, a group that also includes cocaine and heroin. While these drugs have a well-documented history of addiction and harm, ...

BIOFAIR roadmap for an integrated biological and environmental data network

2025-10-15

The Biodiversity Collections Network (BCoN), in collaboration with the American Institute of Biological Sciences (AIBS), has developed a comprehensive roadmap toward an integrated biological and environmental data network. The initiative, known as the Building an Integrated, Open, Findable, Accessible, Interoperable, and Reusable (BIOFAIR) Data Network project, addresses the urgent need to connect fragmented data held in biodiversity collections and other biological and environmental data repositories to tackle pressing societal challenges, including biodiversity loss, climate change, invasive ...

Violence against women and children among top health threats: New global study reveals disease burden far larger than previously estimated

University of Maryland School of Medicine names distinguished scientist and academic leader Gerald M. Wilson, PhD, as Chair of the Department of Biochemistry and Molecular Biology

First-trimester mRNA COVID-19 vaccination and risk of major congenital anomalies

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: