First-trimester mRNA COVID-19 vaccination and risk of major congenital anomalies

JAMA Network Open

2025-10-15

(Press-News.org) About The Study: In this cohort study of pregnancies exposed to messenger RNA (mRNA) COVID-19 vaccines in the first trimester, exposure was not associated with an increased risk of any major congenital malformations, overall, by organ group, or by individual major congenital malformation, supporting the safety of mRNA COVID-19 vaccines in early pregnancy.

Corresponding Authors: To contact the corresponding authors, email Clement Bernard, MSc (clement.bernard@ansm.sante.fr) and Mahmoud Zureik, MD, PhD (mahmoud.zureik@ansm.sante.fr).

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.38039)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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First-trimester mRNA COVID-19 vaccination and risk of major congenital anomalies

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