Glucose-lowering medication classes and cardiovascular outcomes in patients with type 2 diabetes

JAMA Network Open

2025-10-15

(Press-News.org) About The Study: In this study, major adverse cardiovascular event risk varied significantly by medication class, with most protection achieved with sustained treatment with glucagon-like peptide-1 receptor agonists (GLP-1RAs) followed by sodium-glucose cotransporter-2 inhibitors (SGLT2is), sulfonylureas, and dipeptidyl peptidase-4 inhibitors. The magnitude of benefit of GLP-1RAs over SGLT2is depended on baseline age, atherosclerotic cardiovascular disease, heart failure, and kidney impairment. These results, along with consideration of cost, availability, and collateral clinical benefits, may inform treatment decisions for adults with type 2 diabetes.

Corresponding Author: To contact the corresponding author, Romain Neugebauer, PhD, email romain.s.neugebauer@kp.org.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.36100)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Glucose-lowering medication classes and cardiovascular outcomes in patients with type 2 diabetes

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