GLP-1 receptor agonist use and survival among patients with type 2 diabetes and brain metastases

JAMA Network Open

2026-03-11

(Press-News.org) About The Study: The findings of this cohort study suggest that glucagon-like peptide–1 receptor agonist (GLP-1 RA) use was associated with significant reduction in all-cause mortality among patients with cancer with brain metastases and type 2 diabetes, with generally consistent association across subgroups. These results build upon existing evidence that GLP-1 receptor activation modulates pathways relevant to neuro-oncologic health, including attenuation of neuroinflammation, preservation of blood–brain barrier integrity, and reduction of oxidative stress and mitochondrial dysfunction.

Corresponding Author: To contact the corresponding author, Chien-Min Chen, MD, PhD, 96015@cch.org.tw.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2026.1311)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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[Press-News.org] GLP-1 receptor agonist use and survival among patients with type 2 diabetes and brain metastases
JAMA Network Open

GLP-1 receptor agonist use and survival among patients with type 2 diabetes and brain metastases

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