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Medicine 2026-03-18

Premature menopause and lifetime risk of coronary heart disease

JAMA Cardiology
About The Study: In this cohort study, premature menopause was associated with 40% higher lifetime risk of coronary heart disease in Black and white women. This suggests that premature onset of menopause is an important risk-enhancing factor for lifetime risk and should be routinely assessed in clinical practice to consider intensification of preventive efforts.

Corresponding Author: To contact the corresponding author, Priya M. Freaney, MD, email priya.freaney@northwestern.edu.

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(doi:10.1001/jamacardio.2026.0212)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.

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