(Press-News.org) CLEVELAND -- Dr. Leona Cuttler, a pediatric endocrinologist and growth hormone expert from University Hospitals Rainbow Babies and Children's Hospital, is the co-author of an editorial in the New England Journal of Medicine commenting on a new study that found giving girls with Turner syndrome low doses of estrogen, as well as growth hormone, years before the onset of puberty, increases their height and offers other benefits.
With her co-author Dr. Robert L. Rosenfield, a pediatric endocrinologist with the University of Chicago Medical Center, Dr. Cuttler writes, "The use of growth hormone and estrogen has a long and often controversial history in the manipulation of growth."
About the new study, they write that the results confirm those of previous, less rigorous studies showing that treatment with growth hormone significantly increased adult height in patients with Turner's syndrome.
Drs. Cuttler and Rosenfield say the results suggest a modest but intriguing synergism between growth hormone and low-dose estrogen in promoting growth.
"The impact of these findings on practice and policy will depend not only on their statistical significance but also on whether the observed changes in height translate into clinically meaningful benefit. The ability to increase height should not be the sole yardstick for assessing benefit," the editorial states.
"Since growth hormone is well entrenched in the management of Turner's syndrome, the current findings support this aspect of practice but are not likely to change it. Yet the results underscore the need for a measured approach, which includes avoiding unrealistic expectations, when families embark on growth hormone therapy. The early use of low-dose estrogen in conjunction with growth hormone is an interesting possibility. An optimal estrogen-replacement regimen could potentially shorten the period of growth hormone treatment, reduce costs, and improve patient satisfaction. However, implementation would be hampered by the lack of a convenient means to deliver the very small estrogen doses that seem to be optimal for height augmentation."
The authors advise caution when considering supplementing growth hormone treatment with early, low-dose estrogen in Turner's syndrome. "The current results show trends that do not consistently reach significance and show only modest synergy between growth hormone and estrogen in achieving height augmentation, as compared with growth hormone alone. The suggested potential benefits of estrogen on cognition are based on earlier short-term data, and long-term data are needed. We must be concerned about unexpected risks posed by estrogen, being mindful of surprising adverse outcomes of estrogen use in other settings," they write.
According to the National Institutes of Health, Turner syndrome occurs in 1 out of 2,500 female births worldwide and develops when a female (X) sex chromosome is missing in cells or is abnormal. These girls are typically of short stature and have a loss of ovarian function.
###
Dr. Cuttler directs the Center for Child Health and Policy and the Division of Pediatric Endocrinology, Diabetes, and Metabolism at UH Rainbow Babies and Children's Hospital and is on the faculty of the Case Western Reserve University School of Medicine. Dr. Rosenfield is in the Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, University of Chicago Medical Center.
Assessing the value of treatments to increase height
UH Rainbow Babies & Children's growth hormone expert co-authors New England Journal of Medicine editorial
2011-04-02
ELSE PRESS RELEASES FROM THIS DATE:
Memphis Classifieds Directory Offers Marketing Alternatives to Local Businesses
2011-04-02
As the internet grows more and more businesses are looking for ways to increase their exposure on the web. There are so many choices from building a website to joining social media platforms. And many of these take a lot of time to learn or use.
There is one option however that makes it easy for Memphis businesses to get online and promote their business and services. This new option is offered by EverythingMemphis.com a new Memphis website offering from Glarrette Publishing.
"If you want to increase traffic to your website or business, we're offering an easy way ...
Age-related conditions develop faster in adults with diabetes
2011-04-02
Contact: Ian Demsky
idemsky@umich.edu
734-764-2220
University of Michigan Health System
Margarita Wagerson
mbauza@umich.edu
Age-related conditions develop faster in adults with diabetes
Patients in their 50s with diabetes have nearly double the risk for developing 'geriatric' ailments, study finds
Middle-aged adults with diabetes are much more likely to develop age-related conditions than their counterparts who don't have diabetes, according to a new study by the University of Michigan Health System and VA Ann Arbor Healthcare System.
Adults between 51 and ...
NIH investigators find link between DNA damage and immune response
2011-04-02
Researchers offer the first evidence that DNA damage can lead to the regulation of inflammatory responses, the body's reaction to injury. The proteins involved in the regulation help protect the body from infection.
The study, performed by scientists at the National Institute of Environmental Health Sciences (NIEHS), which is part of the National Institutes of Health, is one of the first studies to come out of the recently established NIEHS Clinical Research Unit (CRU) (http://www.niehs.nih.gov/research/clinical/join/durham/index.cfm).
Appearing in the March 31 issue ...
University presidents, senators discuss importance of scientific research to economy
2011-04-02
Washington, DC – University leaders and U.S. Senators gathered for a roundtable discussion today at the Capitol on the vital role university-based scientific research plays in fueling innovation and sparking economic growth.
The event was organized by the Senate Democratic Steering and Outreach Committee, chaired by Sen. Mark Begich (D-AK), and included participation by Sens. Daniel Akaka (HI), Benjamin Cardin (MD), Kay Hagan (NC), Bernard Sanders (VT), and Debbie Stabenow (MI) and the following university leaders: Joseph Aoun, president of Northeastern University in ...
Life as Mystery in Guy Marino's Faces Series at Agora Gallery
2011-04-02
Chelsea's Agora Gallery will feature an originally Italian artist, Guy Marino, in Altered States of Reality: an Exhibition of Analog and Digital Fine Art Photography. The exhibition is scheduled to run from April 19, 2011 through May 10, 2011 (opening reception: Thursday, April 21, 2011).
About the Artist
Guy Marino creates art that centers around contradictions. Fusing elements of his oil painting with original photography and cutting edge digital enhancement techniques, Marino relies on duality to form a distinct platform for his art. His large-scale archival digital ...
Fossil is best look yet at an ancestor of buttercups
2011-04-02
BLOOMINGTON, Ind. -- Scientists from the United States and China have discovered the first intact fossil of a mature eudicot, a type of flowering plant whose membership includes buttercups, apple trees, maple trees, dandelions and proteas. The 125 million-year-old find, described in this week's Nature, reveals a remarkably developed species, leading the scientists to argue for an earlier origin of the eudicots -- and perhaps flowering plants in general.
"This fossil opens up a new way of thinking about the evolution of some of the first flowering plants," said Indiana ...
Welcomemat Services Looks to Greet New Movers in Houston
2011-04-02
On the heels of the recent launch of their franchise system, Welcomemat Services, a loyalty marketing firm that specializes in bringing new residents together with local businesses, will be exhibiting at the National Franchise & Business Opportunities Expo in Houston at Reliant Park on April 16-17, 2011.
During the expo, Welcomemat Services will be speaking with anyone interested in learning more about the company's franchise opportunities and will be exhibiting during show hours.
"The expo presents an ideal opportunity to discuss the growth of the local advertising ...
Poop reveals an immigrant in Isle Royale wolves' gene pool
2011-04-02
The wolves and moose of Isle Royale have done it again. They've surprised the scientists who have spent more than half a century studying them.
In a journal article published online today in the Proceedings of the Royal Society and in their 2010-2011 annual report, Michigan Technological University researchers John A. Vucetich and Rolf O. Peterson tell an unexpected tale of genetic immigration. In 1997, a virile male wolf crossed an ice bridge from Canada to the remote island national park in northern Lake Superior. He was physically larger than most Isle Royale wolves, ...
Probiotic bacteria could help treat Crohn's disease
2011-04-02
New research suggests that infection with a probiotic strain of E. coli bacteria could help treat an reduce the negative effects of another E. coli infection that may be associated with Crohn's disease. Researchrs from the University of Auckland, New Zealand publish their results in the April 2011 issue of the journal Applied and Environmental Microbiology.
Crohn's disease is a common chronic disorder that affects the gastrointestinal tract and is believed to develop as a result of an aberrant immune response to intestinal microbes in a genetically susceptible host. ...
LateRooms.com - Watch A Midsummer Night's Dream in Perth
2011-04-02
One of William Shakespeare's most beloved comedies, A Midsummer Night's Dream, opens in Perth in the coming weeks.
The classic tale of love, magic and mischief follows the story of Hermia and Lysander, who flee into the woods to protect their relationship.
They find themselves trapped in the middle of a dispute between the King and Queen of the Fairies, while a group of amateur actors also get caught up after visiting the forest to rehearse their latest play.
James Beck, Elizabeth Blackmore and Benj D'Addario are among the cast for the Black Swan State Theatre ...
LAST 30 PRESS RELEASES:
New strategies to enhance chiral optical signals unveiled
Cambridge research uncovers powerful virtual reality treatment for speech anxiety
2025 Gut Microbiota for Health World Summit to spotlight groundbreaking research
International survey finds that support for climate interventions is tied to being hopeful and worried about climate change
Cambridge scientist launches free VR platform that eliminates the fear of public speaking
Open-Source AI matches top proprietary model in solving tough medical cases
Good fences make good neighbors (with carnivores)
NRG Oncology trial supports radiotherapy alone following radical hysterectomy should remain the standard of care for early-stage, intermediate-risk cervical cancer
Introducing our new cohort of AGA Future Leaders
Sharks are dying at alarming rates, mostly due to fishing. Retention bans may help
Engineering excellence: Engineers with ONR ties elected to renowned scientific academy
New CRISPR-based diagnostic test detects pathogens in blood without amplification
Immunotherapy may boost KRAS-targeted therapy in pancreatic cancer
Growing solar: Optimizing agrivoltaic systems for crops and clean energy
Scientists discover how to reactivate cancer’s molecular “kill switch”
YouTube influencers: gaming’s best friend or worst enemy?
uOttawa scientists use light to unlock secret of atoms
NJIT mathematician to help map Earth's last frontier with Navy grant
NASA atmospheric wave-studying mission releases data from first 3,000 orbits
‘Microlightning’ in water droplets may have sparked life on Earth
Smoke from wildland-urban interface fires more deadly than remote wildfires
What’s your body really worth? New AI model reveals your true biological age from 5 drops of blood
Protein accidentally lassos itself, helping explain unusual refolding behavior
With bird flu in raw milk, many in U.S. still do not know risks of consuming it
University of Minnesota research team awarded $3.8 million grant to develop cell therapy to combat Alzheimer’s disease
UConn uncovers new clue on what is leading to neurodegenerative diseases like Alzheimer’s and ALS
Resuscitation in out-of-hospital cardiac arrest – it’s how quickly it is done, rather than who does it
A closer look at biomolecular ‘silly putty’
Oxytocin system of breastfeeding affected in mothers with postnatal depression
Liquid metal-enabled synergetic cooling and charging: a leap forward for electric vehicles
[Press-News.org] Assessing the value of treatments to increase heightUH Rainbow Babies & Children's growth hormone expert co-authors New England Journal of Medicine editorial