PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Anti-inflammatory drugs reduce effectiveness of SSRI antidepressants

2011-04-26
(Press-News.org) Scientists at the Fisher Center for Alzheimer's Disease Research at The Rockefeller University, led by Paul Greengard, Ph.D., and Jennifer Warner-Schmidt, Ph.D., have shown that anti-inflammatory drugs, which include ibuprofen, aspirin and naproxen, reduce the effectiveness of the most widely used class of antidepressant medications, the selective serotonin reuptake inhibitors, or SSRIs, taken for depression and obsessive-compulsive disorder and anxiety disorders. This surprising discovery, published online this week in the Proceedings of the National Academy of Sciences, may explain why so many depressed patients taking SSRIs do not respond to antidepressant treatment and suggests that this lack of effectiveness may be preventable. The study may be especially significant in the case of Alzheimer's disease. Such patients commonly suffer from depression and unless this can be treated successfully, the course of the illness is likely to be more severe. Depression in the elderly is also a risk factor for developing Alzheimer's Disease and researchers have suggested that treating depression in the elderly might reduce the risk of developing the disease.

In the recent study, investigators treated mice with antidepressants in the presence or absence of anti-inflammatory drugs. They then examined how the mice behaved in tasks that are sensitive to antidepressant treatment. The behavioral responses to antidepressants were inhibited by anti-inflammatory/analgesic treatments. They then confirmed these effects in a human population. Depressed individuals who reported anti-inflammatory drug use were much less likely to have their symptoms relieved by an antidepressant than depressed patients who reported no anti-inflammatory drug use. The effect was rather dramatic since, in the absence of any anti-inflammatory or analgesic use, 54 percent of patients responded to the antidepressant, whereas success rates dropped to approximately 40 percent for those who reported using anti-inflammatory agents.

"The mechanism underlying these effects is not yet clear. Nevertheless, our results may have profound implications for patients, given the very high treatment resistance rates for depressed individuals taking SSRIs," notes Dr. Warner-Schmidt.

Dr. Greengard adds, "Many elderly individuals suffering from depression also have arthritic or related diseases and as a consequence are taking both antidepressant and anti-inflammatory medications. Our results suggest that physicians should carefully balance the advantages and disadvantages of continuing anti-inflammatory therapy in patients being treated with antidepressant medications."

### This research was supported in part by grants from the National Institute of Mental Health and the National Institute on Aging, both parts of the federal government's National Institutes of Health and The Fisher Center for Alzheimer's Research Foundation.


ELSE PRESS RELEASES FROM THIS DATE:

Pratt Home Builders Joins NewHomesAmerica.com Rebate Program.

2011-04-26
NewHomesAmerica.com, a new website that offers home buyers a rebate of 1.25% of the price of their new home if they buy from a participating builder, announced today that Pratt & Associates, which has more than 10 years of experience developing over 30 new home communities in Tennessee, Georgia and Mississippi is participating in its unique Buyer Rebate Program. Pratt & Associates is constructing new home communities in Chattanooga, Franklin, Ooltewah, and Collegedale, Tennessee selling single family detached homes at prices ranging from $100,000 to $800,000. ...

Study finds keys to working with Latino church to fight domestic abuse

2011-04-26
Latinos are the fastest growing population in the United States and have relatively high rates of domestic violence coupled with social and linguistic barriers that can make it difficult for Latino families to access relevant social services. But a new study from North Carolina State University finds Latino religious leaders willing to help address the problem, and identifies cultural factors that may help social-service providers and others form partnerships with these leaders. "The Protestant Latino church leaders who took part in our study were interested in learning ...

Rice-born detector finds heaviest antimatter

2011-04-26
Physicists at Rice University and their collaborators have detected the antimatter partner of the helium nucleus, antihelium-4. This newly observed particle is the heaviest antimatter particle ever detected. Scientists at Rice's Bonner Lab designed and built the new time-of-flight detector that identified antihelium-4. The $7.5 million detector was built by a U.S.-China collaboration led by Rice, with Chinese scientists contributing $2.5 million to the project. The new detector was installed as part of the STAR experiment at the Relativistic Heavy Ion Collider (RHIC) ...

Sculptor Dorothy Frankel Chosen to Exhibit At The Newark Peace Education Summit, May 13-15, 2011

2011-04-26
Award-winning sculptor Dorothy Frankel has been chosen to exhibit five bronze sculptures at the Newark Peace Education Summit. The three-day conference focuses on peacemaking practices from around the world, May 13-15, 2011 at the New Jersey Performing Arts Center in Newark, New Jersey. Notable speakers at the event include His Holiness the Dalai Lama, Newark Mayor Cory Booker, Somaly Mam, Nobel Laureates and peace advocates from a wide cross section of cultures. "My work is about peace, love, compassion so it' s a great honor to be chosen to display my hand sculptures ...

Psychologists warn that therapies based on positive emotions may not work for Asians

2011-04-26
Thinking happy thoughts, focusing on the good and downplaying the bad is believed to accelerate recovery from depression, bolster resilience during a crisis and improve overall mental health. But a new study by University of Washington psychologists reveals that pursuing happiness may not be beneficial across all cultures. In a survey of college students, Asian respondents showed no relationship between positive emotions and levels of stress and depression. For European-American participants, however, the more stress and depression they felt, the fewer positive emotions ...

A study analyzes the actual role of R+D's in patents

A study analyzes the actual role of R+Ds in patents
2011-04-26
This release is available in Spanish. For some time now there has been a certain degree of controversy regarding the effect of patents on the competitiveness of an economy. There are those who maintain that innovation is reduced when rights to a monopoly are given to a patent holder for a period of time, while others believe that it is the compensation necessary so that firms invest in R+D without having others take advantage of the innovations. The aim of the work of these researchers is to study the relationship between R+D and patents in a general context to be ...

Book Marketing, The 'Authors Marketing Powerhouse', Announces The Authors Show Lineup For The Week Of April 25, 2011

2011-04-26
Don McCauley of the Free Publicity Focus Group and Danielle Hampson of eBroadcastMedia.com, founders of Book Marketing, announced today The Authors Show radio and TV weekly broadcast schedule. Book Marketing, branded as 'The Authors Marketing Powerhouse', allows authors and publishers the opportunity to upload photos, bios, book covers, video and book trailers. The site also offers discussion forums, segmented special interest groups and allows for event listings. Each author can develop a personalized page. In addition the site allows for integration with Facebook and ...

Mafiz Ali's Royal Wedding Menu at Ayr Spice Indian Restaurant

2011-04-26
Celebrity TV chef Mafiz Ali is preparing a sumptuous feast at his Ayr Spice Indian Restaurant in Minishant, South Ayrshire for customers old and new to celebrate the Royal Wedding of Prince William and Kate Middleton this week. It will be a banquet fit for a future King and Queen. Ayr Spice Indian Restaurant, Minishant, South Ayrshire, Scotland Royal Wedding Menu Available Friday and Saturday 29/30 April 2011 GBP24.95 including welcome drink! Choice of drink and papadoms with chutneys on arrival STARTERS Royal Mixed Platter - Mixed dishes Royal ...

Radar shows promise for detecting concussions in athletes and soldiers

Radar shows promise for detecting concussions in athletes and soldiers
2011-04-26
Walking and thinking at the same time can be especially difficult for persons who've suffered concussions, and scientists hope to use that multitasking challenge -- measured by a simple radar system -- to quickly screen individuals who may have suffered brain injuries. By asking an individual to walk a short distance while saying the months of the year in reverse order, researchers at the Georgia Tech Research Institute (GTRI) can determine if that person is impaired and possibly suffering from a concussion. This simple test, which could be performed on the sideline of ...

IntelliVocab 1.5 Released to Improve English Vocabulary Interactively

2011-04-26
Faqden Labs is pleased to announce IntelliVocab 1.5 (formerly PowerVocab), an application for iOS devices which personalizes the English vocabulary learning for competitive exams and personal improvement. Being designed by students of MIT, IntelliVocab 1.5 is based on the latest research from MIT Computer Science and Web Semantics Lab allowing users to master English vocabulary in the most effective way. IntelliVocab completely controls the learning environment, so that users do not have to plan the learning approach. All they need to do is interact. Powerful enough ...

LAST 30 PRESS RELEASES:

Face‑/edge‑shared 3D perovskitoid single crystals with suppressed ion migration for stable X‑ray detector

Multiple solutions help fly embryos overcome the fundamental problem of ‘tissue tectonic collision’

GLP-1 weight-loss drugs pose hidden risks for young women

Strategies for enhancing energy‑level matching in perovskite solar cells: An energy flow perspective

3D‑printed boron‑nitrogen doped carbon electrodes for sustainable wastewater treatment via MPECVD

Screening anionic groups within zwitterionic additives for eliminating hydrogen evolution and dendrites in aqueous zinc ion batteries

New tectonic geodynamics textbook bridges scientific disciplines

Tiny and powerful – metamaterial lenses for your phones and drones

Study used AI models to improve prediction of chronic kidney disease progression to end stage renal disease

Peanut shell biochar composite shows promise for removing antibiotic-resistant bacteria from aquaculture wastewater

Compact genetic light switches transform disease control

Sunglasses for plants, and sustainable agriculture

Nearly half of those with diabetes unaware they have the disease

Emergency department visits by uninsured children in Texas soar 45% after COVID-era federal funding ends

Bright children from poorer backgrounds twice as likely to receive hospital mental health treatment than affluent high-achievers

‘Artificial cartilage’ could improve arthritis treatment

Breathing device could have profound impact on survival for people with sleep apnoea and type 2 diabetes

Artificial intelligence assessment indicates stress levels in farmed Amazonian fish

Keith Cole receives grant to conduct integrated research on mobility, cognition and aging

Internationally recognized malaria researcher Stefan Kappe, Ph.D., appointed new director of the UM School of Medicine's Center for Vaccine Development and Global Health

Lung cancer genetics study launches open-source data platform to research community

Pre-conception radiation exposure from CT scans increases risk for miscarriage and birth defects

Boston University appoints Kenneth Lutchen to top research job

For video-on-demand platforms, release strategy matters: streaming episodes gradually boosts consumers’ searches, subscription rates

Sleep strengthens muscle and bone by boosting growth hormone levels. Here's how

Only 1 in 7 online health images show proper technique to accurately measure blood pressure

Children receiving biofeedback speech therapy improved faster than with traditional methods

Scientists discover why the flu is more deadly for older people

The salmon superfood you’ve never heard of

How does chemotherapy disrupt circadian rhythms?

[Press-News.org] Anti-inflammatory drugs reduce effectiveness of SSRI antidepressants