(Press-News.org) Lower back pain due to Modic changes can be hard to treat and the currently recommended therapy of exercise and staying active often does not help alleviate the pain. Results of a trial, published in BioMed Central's open access journal BMC Medicine, comparing exercise therapy, and staying active, to daily rest and lumbar support, showed that both treatments resulted in the same small level of improvement in pain, disability, and general health.
Modic changes (MC) in the spine, where the bone marrow is infiltrated by serum (fluid), fatty deposits, or by sclerosis, can only be seen using Magnetic Resonance Imaging (MRI). It has been suggested that these MC, associated with non-muscular lower back pain, are caused by mechanical stress and therefore might be more responsive to rest than to exercise. This study, based at the Spine Centre of Southern Denmark, was designed to treat patients for a 10 week trial (with follow up after one year). It consisted of either two hours rest a day, and wearing a lumbar support to help reduce load on the spine, or exercise therapy, once a week, supplemented by active living.
The study measured levels of pain, disability, general health, depression and the number of patients achieving a minimum clinically important improvement in their condition. Patients also reported any back problems or sick leave in weekly text messages (SMS). The team led by Rikke K Jensen found no differences for any of the makers between the two groups at either the 10 week or the year catch up. Similarly there was no difference in the course of the disease between the two groups.
It is also well known that a moderate amount of exercise is beneficial to general physical and mental health so perhaps the improvements seen for both groups were due to the patient 'taking control' of their disease rather than the treatment itself. Mrs Jensen countered, "It seems possible however, since lower back pain for these patients did not improve more with rest than exercise, that the MC itself might not be causing pain, that two hours of rest a day was not enough, or that different types of MC may respond better than others to rest. Further studies into these unexpected results will help us identify who will respond best to which treatment."
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Notes to Editors
1. Rest versus exercise as treatment for patients with low back pain and Modic changes. A randomised controlled clinical trial.
Rikke K Jensen, Charlotte Leboeuf-Yde, Niels Wedderkopp, Joan S Sorensen and Claus Manniche
BMC Medicine (in press)
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Article citation and URL available on request at press@biomedcentral.com on the day of publication.
2. BMC Medicine - the flagship medical journal of the BMC series - publishes original research articles, commentaries and reviews in all areas of medical science and clinical practice. To be appropriate for BMC Medicine, articles need to be of outstanding quality, broad interest and special importance. BMC Medicine (ISSN 1741-7015) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, EMBASE, Scopus, Current Contents, Thomson Reuters (ISI) and Google Scholar.
3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.
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