PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Study examines outcomes among patients treated in universal health care system

2012-03-14
(Press-News.org) CHICAGO – Among hospitals in Ontario, Canada, those with higher levels of spending, which included higher intensity nursing and greater use of specialists and procedures, had an associated lower rate of deaths, hospital readmissions, and better quality of care for severely ill hospitalized patients, according to a study in the March 14 issue of JAMA.

Studies have investigated whether higher health care spending produces better patient outcomes and higher quality of care, with conflicting evidence in the United States and other countries. "The extent to which better spending produces higher-quality care and better patient outcomes in a universal health care system with selective access to medical technology is unknown," according to background information in the article.

Therese A. Stukel, Ph.D., of the Institute for Clinical Evaluative Sciences, Toronto, and colleagues examined whether acute care patients admitted to Canadian hospitals that treat patients more intensively (and at higher cost) have lower mortality and readmissions and higher quality of care. The study population was comprised of adults (older than age 18 years) in Ontario, Canada, with a first admission for acute myocardial infarction (AMI; heart attack) (n = 179,139), congestive heart failure (CHF) (n = 92, 377), hip fracture (n = 90,046), or colon cancer (n = 26,195) during 1998-2008, with follow-up to 1 year. A hospital's spending intensity index was its end-of-life expenditure index, calculated as the average adjusted spending on hospital, emergency department (ED), and physician services provided to decedents in their last year of life.

Adjusted spending intensity varied about 2-fold across hospitals, with the end-of-life expenditure index ranging from U.S. $21,978 - $44,955 and acute care expenditure index from U.S. $19,281 - $32,548 per capita per year. Higher-spending hospitals tended to be higher-volume teaching or community hospitals; be located in urban areas; be associated with regional cancer centers, and have specialized services. Attending physicians in these hospitals were more likely to be specialists or to care for a higher volume of patients with that condition. Patients admitted to higher-spending hospitals had longer lengths of stay, were less likely to be admitted to an intensive care unit, and had more medical specialist visits during the index episode. Cardiac patients admitted to higher-spending hospitals were more likely to receive cardiac interventions and evidence-based discharge medications.

The researchers found that in the highest- vs. lowest-spending hospitals, respectively, the age- and sex-adjusted 30-day mortality rate was 12.7 percent vs. 12.8 percent for AMI, 10.2 percent vs. 12.4 percent for CHF, 7.7 percent vs. 9.7 percent for hip fracture, and 3.3 percent vs. 3.9 percent for colon cancer. "The age-and sex-adjusted 30-day major cardiac event rate was 17.4 percent vs. 18.7 percent for patients with AMI and 15.0 percent vs. 17.6 percent for those with CHF. The age- and sex-adjusted 30-day readmission rate was 23.1 percent vs. 25.8 percent for patients with hip fracture and 10.3 percent vs. 13.1 percent for those with colon cancer. In higher-spending hospitals, age- and sex-adjusted mortality and readmission rates were lower for all cohorts," the authors write. Results for 1-year mortality, readmissions, and major cardiac events were similar.

"Higher-spending hospitals had higher nursing staff ratios, and their patients received more inpatient medical specialist visits, interventional (AMI cohort) and medical (AMI and CHF cohorts) cardiac therapies, preoperative specialty care (colon cancer cohort), and postdischarge collaborative care with a cardiologist and primary care physician (AMI and CHF cohorts)."

The authors add that to place the study in context, the United States has a 3- to 4-times higher per capita supply of specialized technology, such as computed tomography and magnetic resonance imaging scanners, but a similar supply of acute care beds and nurses. "Ontario 2001 population rates of cardiac testing and revascularization lagged behind corresponding 1992 U.S. rates and paralleled the supply of cardiologists and catheterization facilities. It is therefore possible that Canadian hospitals, with fewer specialized resources, selective access to medical technology, and global budgets, are using these resources more efficiently, especially during the inpatient episode for care-sensitive conditions. Canada's health care expenditures per capita are about 57 percent of those in the United States. At this spending level, there might still be a positive association between spending and outcomes."

"These results suggest that it is critical to understand not simply how much money is spent but whether it is spent on effective procedures and services," the researchers conclude.

(JAMA. 2012;307[10]:1037-1045. Available pre-embargo to the media at www.jamamedia.org)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Please Note: For this study, there will be multimedia content available, including the JAMA Report video, embedded and downloadable video, audio files, text, documents, and related links. This content will be available at 3 p.m. CT Tuesday, March 13, at this link.

Editorial: The Relationship Between Cost and Quality

Karen E. Joynt, M.D., M.P.H., and Ashish K. Jha, M.D., M.P.H., of the Harvard School of Public Health, Boston, write in an accompanying editorial that "the relationship between cost and quality is entirely dependent on whom and what are examined and how the money is spent."

"In regions of the United States where the delivery system is fragmented, the resulting care is, in aggregate, of poor quality and very high cost. At the systems level, high costs may represent spending on wasteful, inefficient, and duplicative services. Yet this appears less true for individual clinicians and health care centers. For instance, many physicians and hospitals that are 'expensive' may in fact be spending money directly on patient care, with resultant better outcomes. This is not to suggest that there are not inefficiencies in hospital care. It simply suggests that when hospitals spend more, the expenditures often involve resources for nurses, specialists, and technology— all of which in aggregate improve the outcomes of acutely ill patients."

(JAMA. 2012;307[10]:1082-1083. Available pre-embargo to the media at www.jamamedia.org)

Editor's Note: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.

### To contact Therese A. Stukel, Ph.D., call Deborah Creatura at 416-480-4780 or email deborah.creatura@ices.on.ca.

To contact editorial co-author Ashish K. Jha, M.D., M.P.H., call Todd Datz at 617-432-8413 or email tdatz@hsph.harvard.edu.



ELSE PRESS RELEASES FROM THIS DATE:

Study finds association between genetic mutation and age at diagnosis for common childhood cancer

2012-03-14
CHICAGO – Certain mutations of the gene ATRX were associated with age at diagnosis in children and young adults with advanced-stage neuroblastoma, a cancer that grows in parts of the nervous system, according to a study in the March 14 issue of JAMA. Neuroblastoma is the most common extracranial (outside the cranium) solid tumor of childhood and accounts for 15 percent of all cancer-related deaths in children. "Half of the patients (50 percent) with neuroblastoma present with metastatic disease; with current treatment approaches, the age at diagnosis has proven to be ...

Endoscopic procedure may result in better outcomes for patients with infected severe pancreatitis

2012-03-14
CHICAGO – In a small, preliminary trial, patients with infected necrotizing pancreatitis (severe form of the disease involving devitalized pancreatic tissue) who received a less-invasive procedure, endoscopic transgastric necrosectomy (removal of the pancreatic tissue), had an associated lower risk of major complications and death compared to patients who had surgical necrosectomy, according to a study in the March 14 issue of JAMA. "Acute pancreatitis is a common and potentially lethal disorder. In the United States alone, more than 50,000 patients are admitted with ...

Treating intestinal E. coli infection with antibiotic may reduce duration of bacterial carriage

2012-03-14
CHICAGO – In the E coli outbreak in Germany in May 2011, treatment with azithromycin was associated with a lower frequency of long-term carriage of the bacteria and shorter duration of shedding of the bacteria in stool specimens, according to a study in the March 14 issue of JAMA. "Since May 2011, a large outbreak of Shiga toxin-producing Escherichia coli (STEC) has caused 3,816 documented infections in Germany, including 845 confirmed cases of hemolytic uremic syndrome [HUS; a condition characterized by the breakup of red blood cells and kidney failure]," the authors ...

Cancer drug improves memory in mouse model of Alzheimer's disease

Cancer drug improves memory in mouse model of Alzheimers disease
2012-03-14
Washington, DC — A compound that previously progressed to Phase II clinical trials for cancer treatment slows neurological damage and improves brain function in an animal model of Alzheimer's disease, according to a study in the March 14 issue of The Journal of Neuroscience. The findings suggest the drug epothilone D (EpoD) may one day prove useful for treating people with early-stage Alzheimer's disease. Nerve cells in people with Alzheimer's disease contain tangles — distorted clumps made up of the protein tau. Under normal circumstances, tau helps stabilize structures ...

Sleep apnea treatment may protect against heart failure

2012-03-14
A nightly breathing treatment may do more than help people with obstructive sleep apnea get a good night's rest — it may also help prevent heart failure. In a study published in Circulation: Heart Failure, a journal of the American Heart Association, researchers in the U.K. discovered that moderate to severe obstructive sleep apnea (OSA) can cause changes in the heart's shape and function, similar to the effects of hypertension. These changes include increased mass, thickening of the heart wall and reduced pumping ability. But, six months after continuous positive airway ...

Text messages help HIV patients stick to antiretroviral drug therapy

2012-03-14
Mobile phones could play a valuable role in helping HIV patients to take their medication every day, according to a new Cochrane Systematic Review. The researchers found that patients were less likely to miss doses if they were sent weekly mobile phone text message reminders. Text messaging is increasingly being used as a means of support in health care, including to help promote attendance at clinics and hospitals, and to increase contact between patients and care workers. There is also some evidence that text messaging helps tuberculosis patients to take their daily ...

Specialist cancer care may improve patient outcomes

2012-03-14
Survival rates for cancer patients may be improved by treatment in specialised cancer centres, according to Cochrane researchers. In a review of recent studies, they found that women diagnosed with gynaecological cancer lived longer when treated in specialist compared to non-specialist units. In the past, cancer patients were often treated by non-specialist surgeons and hospitals. This is changing and in developed countries, most cancer care is now organised into networks of specialised centres, with on-site experts and specialised nursing staff. This centralised approach, ...

Pain relief: Poor evidence for non-drug approaches in labor

2012-03-14
There is better evidence for the effectiveness of drug-based approaches for relieving labour pains than non-drug approaches. These are the findings of an all-encompassing publishing in The Cochrane Library, which draws together results from a number of previous reviews on the subject. Many different approaches are used to relieve pain in labour, but not all are supported by strong evidence. The researchers brought together the results of 15 previous Cochrane reviews and three non-Cochrane reviews, including data from 310 trials in total. To try to distinguish between ...

Hospital survival differs among Hispanic and non-Hispanic heart failure patients

2012-03-14
The odds of surviving their hospital stay for heart failure differ between Hispanic and non-Hispanic white patients according to their level of heart function, even when they received equal care in hospitals participating in the American Heart Association's Get With The Guidelines®–Heart Failure quality improvement program, researchers said. The study, published in the American Heart Association journal, Circulation: Heart Failure, is the first in which researchers compare the care and outcomes of Hispanic to non-Hispanic heart failure patients admitted to U.S. hospitals ...

Dietary patterns exist among US adults based on demographics

2012-03-14
Scientists say they have identified five eating patterns for U.S. adults that are strongly influenced by age, race, region, gender, income and education. Presenting their findings at the American Heart Association's Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2012 Scientific Sessions, the scientists said the five dietary patterns are: Southern — fried, processed meats, and sugar sweetened beverages Traditional — Chinese and Mexican food, pasta dishes, pizza, soup and other mixed dishes including frozen or take-out meals Healthy — mostly ...

LAST 30 PRESS RELEASES:

Post-LLM era: New horizons for AI with knowledge, collaboration, and co-evolution

“Sloshing” from celestial collisions solves mystery of how galactic clusters stay hot

Children poisoned by the synthetic opioid, fentanyl, has risen in the U.S. – eight years of national data shows

USC researchers observe mice may have a form of first aid

VUMC to develop AI technology for therapeutic antibody discovery

Unlocking the hidden proteome: The role of coding circular RNA in cancer

Advancing lung cancer treatment: Understanding the differences between LUAD and LUSC

Study reveals widening heart disease disparities in the US

The role of ubiquitination in cancer stem cell regulation

New insights into LSD1: a key regulator in disease pathogenesis

Vanderbilt lung transplant establishes new record

Revolutionizing cancer treatment: targeting EZH2 for a new era of precision medicine

Metasurface technology offers a compact way to generate multiphoton entanglement

Effort seeks to increase cancer-gene testing in primary care

Acoustofluidics-based method facilitates intracellular nanoparticle delivery

Sulfur bacteria team up to break down organic substances in the seabed

Stretching spider silk makes it stronger

Earth's orbital rhythms link timing of giant eruptions and climate change

Ammonia build-up kills liver cells but can be prevented using existing drug

New technical guidelines pave the way for widespread adoption of methane-reducing feed additives in dairy and livestock

Eradivir announces Phase 2 human challenge study of EV25 in healthy adults infected with influenza

New study finds that tooth size in Otaria byronia reflects historical shifts in population abundance

nTIDE March 2025 Jobs Report: Employment rate for people with disabilities holds steady at new plateau, despite February dip

Breakthrough cardiac regeneration research offers hope for the treatment of ischemic heart failure

Fluoride in drinking water is associated with impaired childhood cognition

New composite structure boosts polypropylene’s low-temperature toughness

While most Americans strongly support civics education in schools, partisan divide on DEI policies and free speech on college campuses remains

Revolutionizing surface science: Visualization of local dielectric properties of surfaces

LearningEMS: A new framework for electric vehicle energy management

Nearly half of popular tropical plant group related to birds-of-paradise and bananas are threatened with extinction

[Press-News.org] Study examines outcomes among patients treated in universal health care system