Preventing cellular aging and aging-related degenerative diseases
2012-06-19
(Press-News.org) Age-associated degeneration is caused, at least in part, by accumulated cellular damage, including DNA damage, but how these types of damage drive aging remains unclear. Dr. Paul Robbins and colleagues at the University of Pittsburgh sought to address this question using a mouse model of DNA repair deficiency. The Robbins team found that DNA damage drives aging, in part, by activating NF-κB, a transcription factor that responds to cellular damage and stress. They report that inhibition of NF-κB reduces oxidative stress, oxidative DNA damage, oxidative protein damage, and cellular senescence induced by oxidative damage. Their data suggest that NF-κB inhibitors can mitigate cellular damage and could provide clinical benefit for degenerative changes caused by aging.
INFORMATION:
TITLE:
NF-κB inhibition delays DNA damage–induced senescence and aging in mice
AUTHOR CONTACT:
Paul Robbins
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Phone: (412) 648-9268; Fax: (412) 624-8997; E-mail: probb@pitt.edu
View this article at: http://www.jci.org/articles/view/45785?key=84c4d84388bea61c718c
END
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2012-06-19
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Preventing cellular aging and aging-related degenerative diseases
Age-associated degeneration is caused, at least in part, by accumulated cellular damage, including DNA damage, but how these types of damage drive aging remains unclear. Dr. Paul Robbins and colleagues at the University of Pittsburgh sought to address this question using a mouse model of DNA repair deficiency. The Robbins team found that DNA damage drives aging, in part, by activating NF-κB, a transcription factor that responds to cellular damage and stress. They report that inhibition of NF-κB ...
2012-06-19
It's that season again! The time of year when you can do the unimaginable; swim with the sharks! Each June, Leopard Sharks start to congregate in large groups in the shallow waters of La Jolla Shores. This local phenomenon happens right off the coast, amidst the presence of adventurous swimmers. Don't assume, however, that this activity is reserved only for the extremists. Leopard Sharks are completely harmless and are, in fact, bottom feeders with small mouths. La Jolla Kayak is now offering their seasonal "Snorkel with the Leopard Sharks" guided tour. Experienced ...
2012-06-19
A study of the microbiome of the human nose provides clues to the cause of a chronic sinus condition and potential strategy for a cure. Researchers from the University of California, San Francisco report their findings today at the 2012 General Meeting of the American Society for Microbiology.
Chronic rhinosinusitis (CRS) is characterized by inflammation of the nasal and paranasal sinuses lasting over 12 weeks. Patients suffering from this disease experience a variety of symptoms including congestion, fatigue, and even depression and it can lead to other conditions ...
2012-06-19
Architecture firm Perkins & Will and design firm Mazzetti Nash Lipsey Burch (M+NLB) tapped lean materials management consultants St. Onge to assist in the development of a new hospital design that won Kaiser Permanente's first-ever "Small Hospital, Big Idea" competition. The goal was to design a small, eco-conscious hospital that provided the best in emerging care delivery. St. Onge was asked to join the design team to provide lean materials management and support services consulting.
"Perkins & Will and M+NLB created a small hospital design which ...
2012-06-19
In an effort to save the dwindling honeybee population researchers at the University of Nevada, Las Vegas are looking to viruses to help treat one of the most destructive and widespread bee brood diseases in the United States. They report their findings today at the 2012 General Meeting of the American Society for Microbiology.
"Our food supply depends on the actions of millions of insects such as the common honeybee. Due to the importance of honeybees a pollinators in the agriculture of the United States and therefore the current and future food supply, honeybee health ...
2012-06-19
WASHINGTON, June 18, 2012 — The least appealing part of the world's most popular citrus fruits could soon be more alluring to cosmetic and drug manufacturers and, perhaps, eventually help heat our homes and fuel our cars.
In research described today at the 16th annual Green Chemistry & Engineering Conference, scientists from the United Kingdom said they have developed a sustainable way to extract and find uses for virtually every bit of the 15.6 million tons of orange and other citrus peel discarded worldwide every year. These uses could include biosolvents, fragrances ...
2012-06-19
The quirky community of Peaks Island, Maine may soon be known as more than a vacationer's paradise near Portland. On July 7, its Umbrella Cover Museum—the only one in the world—will count and categorize over 700 umbrella sleeves from nearly 50 countries in an attempt to make Guinness Book of World RecordsTM.
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2012-06-19
SALT LAKE CITY, June 18, 2012 – Scientists worldwide are racing to sequence DNA – decipher genetic blueprints – faster and cheaper than ever by passing strands of the genetic material through molecule-sized pores. Now, University of Utah scientists have adapted this "nanopore" method to find DNA damage that can lead to mutations and disease.
The chemists report the advance in the week of June 18 online edition of the journal Proceedings of the National Academy of Sciences.
"We're using this technique and synthetic organic chemistry to be able to see a damage site as ...
2012-06-19
The Humane Society of Northwest Montana, home of the Charlotte Edkins Animal Adoption Center, announced today the award of a generous $45,000 grant award from the Petco Foundation, headquartered in San Diego, CA. Through the Foundation's "Capital Grant Program", this extraordinary gift will be used to replace the Humane Society's highly visible, beloved, and converted recreational truck known as the "Beagle". The Beagle is now well over 29 years old and maintenance and repairs have reached a point where the asset must be replaced. The Humane Society ...
2012-06-19
Boral Stone Products LLC has announced the appointment of Emily Bonilla as Cultured Stone manufactured stone Area Sales Manager for the Rocky Mountain region. As part of the Western Region of Boral Stone, Bonilla will spearhead the company's sales efforts for the Cultured Stone manufactured stone veneer product in a territory covering the greater Denver market.
"We are pleased to have Emily Bonilla join us as Rocky Mountain Area Sales Manager," said Dennis Merino, Vice President of Sales with Boral Stone Products. "Her knowledge of the Cultured Stone ...
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