(Press-News.org) ROCHESTER, Minn. -- Mayo Clinic researchers have successfully used smaller, folded DNA molecules to stimulate regeneration and repair of nerve coatings in mice that mimic multiple sclerosis (MS). They say the finding, published today in the journal PLoS ONE, suggests new possible therapies for MS patients.
"The problem has been to find a way to encourage the nervous system to regenerate its own myelin (the coating on the nerves) so nerve cells can recover from an MS attack," says L. James Maher III, Ph.D., Mayo Clinic biochemist and senior author on the paper. "We show here that these small molecules, called aptamers, can stimulate repair in the mice we are studying."
More than 200,000 people have multiple sclerosis. There is no cure and no effective therapy to stop progression or repair damage to the myelin sheath that surrounds and protects the nerves. Without that protection, nerve fibers will be damaged, leading to declining mobility and cognitive function, and other debilitating complications.
MS researchers, including Mayo neurologist Moses Rodriguez, M.D., a co-author on this paper, have focused on monoclonal antibodies in mice to stimulate myelin repair. The Rodriguez and Maher teams, working together, have determined that the aptamers are not only effective, but they are easy and cheap to synthesize -- an important point for drug developers. They also are stable and not likely to cause an immune response. This new approach must be validated in other mouse models to see if it might be a candidate for human clinical trials.
The monoclonal antibodies used in earlier research are large and complex, but were shown to promote both cell signaling and remyelination of central nervous system lesions in mice. The aptamers used in this study are less than one-tenth the size of antibodies and are single-strands of DNA containing only 40 nucleotide units.
INFORMATION:
The research was supported by Mayo Clinic and the National Multiple Sclerosis Society.
Co-authors include Branislav Nastasijevic, Brent Wright, Ph.D., John Smestad, and Arthur Warrington, Ph.D., all of Mayo Clinic.
About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit http://www.mayoclinic.org/about and www.mayoclinic.org/news.
Contact:
Bob Nellis
507-284-5005 (days)
507-284-2511 (evenings)
Email: newsbureau@mayo.edu
VIDEO ALERT: Video resources with Dr. Maher are available here.
END
In a process akin to belling an infinitesimal cat, scientists have managed to tag a protein that regulates the neurotransmitter serotonin with tiny fluorescent beads, allowing them to track the movements of single molecules for the first time.
The capability, which took nearly a decade to achieve, makes it possible to study the dynamics of serotonin regulation at a new level of detail, which is important because of the key role that serotonin plays in the regulation of mood, appetite and sleep.
The achievement was reported by an interdisciplinary team of Vanderbilt scientists ...
Salmonella Typhi (S. Typhi) is the causative agent of typhoid fever, a serious health threat resulting in some 22 million new cases yearly and approximately 217,000 fatalities. A number of novel vaccine candidates using live attenuated strains of Salmonella are being developed, but care must be taken to ensure the bacteria are not excreted into the environment following vaccination.
Karen Brenneman and her colleagues at Arizona State University's Biodesign Institute have been examining ways to detect the presence of S. Typhi in stool following inoculation with various ...
Inhibiting a key immune response in mice during initial multi-drug treatment for tuberculosis could — paradoxically — shorten treatment time for the highly contagious lung infection according to new research from Johns Hopkins Children's Center and the Center for TB Research.
Shorter duration of drug therapy is key, researchers say, to increase treatment compliance for the growing global health threat posed by the disease.
In experiments described in the June 27 issue of PLoS ONE, the Johns Hopkins investigators compared a group of TB-infected mice receiving standard ...
Studies on some 55 U.S. men and women with potentially deadly liver or pancreatic cancers show that specialized MRI scans can tell within a month whether highly toxic chemotherapy is working and killing tumor cells long before tumors actually shrink – or fail to shrink.
Using special software and MRI scanners, imaging experts at Johns Hopkins developed their new assay, known as a volumetric functional MRI scan, by exploiting the physiological differences in water movement and absorption inside cancer cells that are dying and those that are not.
The studies are believed ...
Researchers at the Buck Institute for Research on Aging have corrected the genetic mutation responsible for Huntington's Disease (HD) using a human induced pluripotent stem cell (iPSC) that came from a patient suffering from the incurable, inherited neurodegenerative disorder. Scientists took the diseased iPSCs, made the genetic correction, generated neural stem cells and then transplanted the mutation-free cells into a mouse model of HD where they are generating normal neurons in the area of the brain affected by HD. Results of the research are published in the June ...
This press release is available in German.
An organism's ability to make new antibodies and use them to optimize its own immune defenses is of central importance in the fight against pathogens. In the case of severe infections, the overall relative speed with which an immune response proceeds could mean the difference between life and death. An international team of scientists, among them systems immunologist Prof. Michael Meyer-Hermann of the Helmholtz Centre for Infection Research (HZI) of Braunschweig, Germany, has now found that asymmetric division of antibody-producing ...
Researchers have come up with a device that may enable people who are completely unable to speak or move at all to nevertheless manage unscripted back-and-forth conversation. The key to such silent and still communication is the first real-time, brain-scanning speller, according to the report published online on June 28 in Current Biology, a Cell Press publication.
The new technology builds on groundbreaking earlier uses of fMRI brain scans to assess consciousness in people described as being in an unconscious, vegetative state and to enable them to answer yes and no ...
A new study--which includes the first large-scale comparison of fungi that cause rot decay--suggests that the evolution of a type of fungi known as white rot may have brought an end to a 60-million-year-long period of coal deposition known as the Carboniferous period. Coal deposits that accumulated during the Carboniferous, which ended about 300 million years ago, have historically fueled about 50 percent of U.S. electric power generation.
In addition, the study provides insights about diverse fungal enzymes that might be used in the future to help generate biofuels, ...
For want of a nail, the nursery rhyme goes, a kingdom was lost. A similar, seemingly innocuous change—the evolution of a lineage of mushrooms—may have had a massive impact on the carbon cycle, bringing an end to the 60-million year period during which coal deposits were formed.
Coal generated nearly half of the roughly four trillion kilowatt-hours of electricity consumed in the United States in 2010, according to the U.S. Energy Information Administration. This fuel is actually the fossilized remains of plants that lived from around 360 to 300 million years ago. An international ...
University of Alberta researchers have uncovered physical proof that animals existed 585 million years ago, 30 million years earlier than all previous established records show.
The discovery was made U of A geologists Ernesto Pecoits and Natalie Aubet in Uruguay. They found fossilized tracks of a centimetre long, slug-like animal left behind 585 million years ago in a silty sediment.
Along with other U of A researchers, the team determined that the tracks were made by a primitive animal called a bilaterian, which is distinguished from other non-animal, simple life ...
