(Press-News.org) Epidemiologists have determined that levels of hepatitis C virus (HCV) found among injection drug users (IDUs) were higher in individuals who are male or African American even after differences in other factors were considered. The study, which was funded by the National Cancer Institute and performed with collaborators from the National Institutes of Health Clinical Center and the University of California - San Francisco, was the first to simultaneously examine the association of demographic, viral and human genetic factors on HCV RNA levels. Results of the study published in the July issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD), also showed higher levels of HCV among IDUs who were co-infected with human immunodeficiency virus (HIV).
A 2010 report from the Centers for Disease Control and Prevention (CDC) estimates that up to 3.9 million Americans have chronic HCV—a leading cause of liver cancer, end-stage liver disease and liver transplantation. According to the CDC 17,000 new cases and 2,800 acute cases of HCV were reported in 2010. Previous epidemiologic studies suggest one-third of those 18 to 30 year-old IDUs and up to 90% of older IDUs are infected with HCV.
"With such a high incidence and prevalence of hepatitis C virus infection among IDUs, it is important to understand the characteristics of the infection in this group," explains lead author Dr. Thomas O'Brien of the Division of Cancer Epidemiology and Genetics at the National Cancer Institute in Rockville, MD. "The HCV RNA level is an important predictor of response to treatment in patients with chronic hepatitis C. Our study is the first to examine simultaneously the viral, demographic, and genetic factors that impact HCV levels in ethnically diverse IDUs."
Participants were originally recruited for the Urban Health Study—a multi-ethnic group of IDUs in San Francisco. Researchers used interview data and biological samples from participants to analyze demographic, viral and host characteristics of cancer-causing viruses. A total of 1701 participants had detectable HCV RNA and were included in the present study. The median age at enrollment was 46 years and median age of first illicit drug injection was 18 years. Close to 75% of participants were men and 56% were African American, 34% European (non-Hispanic) and 7% Latino (non-African American).
Adjusted analysis revealed that age, gender, racial ancestry, HIV-1 infection, and IL28B rs12979860 genotype were all independently associated with the HCV RNA level. "We know that the level of HCV is an important predictor of treatment response and that these levels seem to be influenced by a number of demographic, clinical, viral and human genetic factors," concludes Dr. O'Brien.
INFORMATION:
Full citation: "HCV RNA Levels in a Multi-Ethnic Cohort of Injection Drug Users:Human Genetic, Viral and Demographic Associations." Lorenzo Uccellini, Fan-Chen Tseng, Alessandro Monaco, Fatma M. Shebl, Ruth Pfeiffer, Myhanh Dotrang, Dianna Buckett, Michael P. Busch, Ena Wang, Brian R. Edlin, Francesco Marincola, Thomas R. O'Brien. Hepatology; (DOI: 10.1002/hep.25652); Print Issue Date: July, 2012.
URL: http://onlinelibrary.wiley.com/doi/10.1002/hep.25652/abstract
About the Author: Dr. Thomas O'Brien is with the Division of Cancer Epidemiology and Genetics at the National Cancer Institute in Rockville, Maryland.
To arrange an interview with Dr. O'Brien please contact the NCI Office of Media Relations at ncipressofficers@mail.nih.gov or at 301-496-4441.
This study is published in Hepatology. Media wishing to receive a PDF of this article may contact sciencenewsroom@wiley.com.
About the Journal:
Hepatology is the premier publication in the field of liver disease, publishing original, peer-reviewed articles concerning all aspects of liver structure, function and disease. Each month, the distinguished Editorial Board monitors and selects only the best articles on subjects such as immunology, chronic hepatitis, viral hepatitis, cirrhosis, genetic and metabolic liver diseases and their complications, liver cancer, and drug metabolism. Hepatology is published on is published by Wiley on behalf of the American Association for the Study of Liver Diseases (AASLD). For more information, please visit http://wileyonlinelibrary.com/journal/hep.
About Wiley
Founded in 1807, John Wiley & Sons, Inc. has been a valued source of information and understanding for more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Wiley and its acquired companies have published the works of more than 450 Nobel laureates in all categories: Literature, Economics, Physiology or Medicine, Physics, Chemistry, and Peace.
Our core businesses publish scientific, technical, medical, and scholarly journals, encyclopedias, books, and online products and services; professional/trade books, subscription products, training materials, and online applications and Web sites; and educational materials for undergraduate and graduate students and lifelong learners. Wiley's global headquarters are located in Hoboken, New Jersey, with operations in the U.S., Europe, Asia, Canada, and Australia. The Company's Web site can be accessed at http://www.wiley.com. The Company is listed on the New York Stock Exchange under the symbols JWa and JWb.
END
Researchers from Spain established that liver stiffness, measured by transient elastography (TE), is an independent predictor of liver failure, hepatocellular carcinoma (HCC), and mortality in cirrhotic patients coinfected with the human immunodeficiency virus (HIV) or acquired immune deficiency syndrome (AIDS), and hepatitis C virus (HCV). Findings available in the July issue of Hepatology, a journal published by Wiley on behalf of the American Association for the Study of Liver Diseases, also show that measurement of liver stiffness predicts potential recovery and survival ...
WASHINGTON — Educational and business leaders want today's students both to master school subjects and to excel in areas such as problem solving, critical thinking, and communication -- abilities often referred to by such labels as "deeper learning" and "21st-century skills." In contrast to the view that these are general skills that can be applied across a range of tasks in academic, workplace, or family settings, a new report from the National Research Council found that 21st-century skills are specific to content knowledge and performance within a particular subject ...
President Barack Obama has one. Comedian Stephen Colbert has one. Elvis Presley has one. Even computer software magnate Bill Gates has one. And now, Bob Marley--the late popular Jamaican singer and guitarist--also has one. So what is it that each of these luminaries have? The answer: they each have a biological species that has been named after them.
Paul Sikkel, an assistant professor of marine ecology and a field marine biologist at Arkansas State University, discovered and just named after Marley a "gnathiid isopod"--a small parasitic crustacean blood feeder that infests ...
Even as we spend more on healthcare every year, the number of people with chronic health problems continues to rise in developed countries like the United States. Most of these chronic health problems – such as obesity, Type 2 diabetes, and cardiovascular disease – can be addressed through lifestyle changes. But knowing that we should make a lifestyle change to improve our health and actually making that lifestyle change are two very different things.
In a new article published in the July 2012 issue of Perspectives on Psychological Science, a journal of the Association ...
If you're a male born to a father who's a strong and enduring community leader, you're far more likely than your less fortunate peers to become a leader yourself, due to the wide range of social advantages accruing from your dad's position.
And even if your old man isn't a leader, other men in your community are more likely to take you under their wing than your sisters, lavishing attention on you and showing you the ropes.
Sound like the basic description of an old boys' network?
Maybe so, but this is also the social structure that prevails among white-faced ...
ARLINGTON, Va.—A new sensor and software suite sponsored by the Office of Naval Research (ONR) recently returned from West Africa after helping partner nations track and identify target vessels of interest as part of an international maritime security operation, officials announced July 10.
Researchers deployed the system, called "Rough Rhino," aboard U.S. aircraft, ships and partner nation ships operating in waters off the coast of Senegal and Cape Verde. Sailors and Coast Guardsmen could access and control the sensors both afloat and ashore, as well as share information ...
COLLEGE STATION, July 10, 2012 – The common barnyard chicken could provide some very un-common clues for fighting off diseases and might even offer new ways to attack cancer, according to a team of international researchers that includes a Texas A&M University professor.
James Womack, Distinguished Professor of Veterinary Pathobiology in the College of Veterinary Medicine & Biomedical Sciences, is co-author of a paper detailing the team's work that appears in the current issue of PNAS (Proceedings of the National Academy of Sciences). Womack was a leader in the international ...
(SACRAMENTO, Calif.) — Most people killed or wounded in stray-bullet shootings were unaware of events leading to the gunfire that caused their injuries, and nearly one-third of the victims were children and nearly half were female, according to a new nationwide study examining an often-overlooked form of gun violence.
The study by Garen Wintemute, professor of emergency medicine and director of the Violence Prevention Research Program at UC Davis School of Medicine and Medical Center, examines mortality rates and other epidemiological aspects of stray-bullet shootings ...
URBANA – A new strategy to manage invasive species and achieve broader conservation goals is being tested in the Grand River Grasslands, an area within the North American tallgrass prairie ecoregion. A University of Illinois researcher along with his colleagues at Iowa State and Oklahoma State Universities enlisted private landowners in a grassroots community-building effort to establish a more diverse landscape for native wildlife.
The Grand River Grasslands has three main problems that pose challenges to conservation efforts: invasive juniper trees, tall fescue, and ...
Researchers have discovered a previously unknown mechanism that promotes the growth and spread of cancer.
The mechanism involves a new role for small regulatory molecules called microRNA.
The findings suggest a new strategy for treating cancer and perhaps diseases of the immune system.
COLUMBUS, Ohio – Tiny vesicles released by tumors cells are taken up by healthy immune cells, causing the immune cells to discharge chemicals that foster cancer-cell growth and spread, according to a study by researchers at The Ohio State University Comprehensive Cancer Center – Arthur ...
