Miriam researchers urge physicians to ask younger men about erectile dysfunction symptoms

(Press-News.org) PROVIDENCE, R.I. – Although erectile dysfunction (ED) has been shown to be an early warning sign for heart disease, some physicians – and patients – still think of it as just as a natural part of "old age." But now an international team of researchers, led by physicians at The Miriam Hospital, say it's time to expand ED symptom screening to include younger and middle-aged men.

In an article appearing in the July issue of the American Heart Journal, they encourage physicians to inquire about ED symptoms in men over the age of 30 who have cardiovascular risk factors, such as smoking, obesity or family history, and in all men with type 2 diabetes.

As many as 30 million American men suffer from ED, or the inability to maintain an erection sufficient for sexual intercourse. ED and cardiovascular disease share a common cause: narrowing of the arteries, resulting in reduced or obstructed blood flow to the organs. They also share similar risk factors, including smoking, diabetes, obesity and high blood pressure. Because the penile arteries are just a fraction smaller than the arteries supplying blood to the heart, symptoms of conditions that can narrow the arteries, such as arteriosclerosis, are likely to present first in the form of erection problems. That's why it is also believed that the more severe the ED, the greater the risk of heart disease-related events, such as heart attack and stroke.

"Erectile dysfunction represents an important first step toward heart disease detection and reduction, yet many health care providers and patients assume it's just a sign of old age, so it may not be something that comes up during an annual physical with a younger man who doesn't fit the ED 'stereotype,'" says lead author Martin Miner, M.D., chief of family medicine and co-director of the Men's Health Center at The Miriam Hospital.

"That's why we urge physicians to discuss sexual function with the majority of their male patients – including diabetic men of all ages and men over the age of thirty with some of the traditional heart disease risk factors, like smoking or a family history," he adds.

Although not all men with ED are at increased risk for cardiovascular disease, Miner says it is the physician's responsibility to make that determination based on aggressive workup and testing. If the patient is found to be at risk, the patient can then receive intensive risk factor management.

Miner and colleagues conducted a literature review of 40 studies that suggest ED is a significant predictor for cardiovascular disease in two populations: men under the age of 60 and men with diabetes. Their analysis supports several widely-held theories, including the role of ED as a significant red flag for cardiovascular disease in younger and middle-aged men.

For example, in the Mayo Clinic's Olmsted County Study, a large, epidemiological study cohort of men from Olmsted County, Minnesota, men 40 to 49 years old with ED were twice as likely to develop coronary artery disease as those who did not have ED. However, ED had less predictive value for men 70 years and older.

Several studies, including a large analysis of more than 6,300 men enrolled in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation) trial, suggest ED is a particularly powerful indicator of cardiovascular disease in diabetic men as well, prompting researchers to call for ED symptom screening in all men with type 2 diabetes.

Miner points out early identification of men at risk for cardiovascular disease has the potential to lower health care costs and improve outcomes.

"There may be a 'window of curability' in which we can intervene early and stop the progression of heart disease," he says. "Also, it may be possible to someday use erectile function as a measurement to tell us if preventive interventions for heart disease are working."

### Miner's co-authors on the paper include Mark Sigman, M.D., co-director of the Men's Health Center and chief of urology at Rhode Island and The Miriam hospitals; Peter Tilkemeier, M.D., interim chair, division of cardiology at Rhode Island and The Miriam hospitals; Allen D. Seftel, M.D., FACS, of the University of Medicine and Dentistry, New Jersey-Robert Wood Johnson Medical School; Ajay Nehra, M.D., of Mayo Clinic; Peter Ganz, M.D., of San Francisco General Hospital and University of California at San Francisco; Robert A. Kloner, M.D., Ph.D., of Good Samaritan Hospital, Los Angeles; Piero Montorsi, M.D., of the University of Milan; Charalambos Vlachopoulos, M.D., of Athens Medical School; Melinda Ramsey, Ph.D., of Melinda Ramsey, LLC; and Graham Jackson, M.D., FRCP, of Guys and St. Thomas Hospitals, London.

Miner is also a clinical associate professor of family medicine and surgery (urology) at The Warren Alpert Medical School of Brown University. In addition, Sigman is a professor of surgery (urology) and Tilkemeier is an associate professor of medicine at Alpert Medical School.

The Miriam Hospital (www.miriamhospital.org) is a 247-bed, not-for-profit teaching hospital affiliated with The Warren Alpert Medical School of Brown University. It offers expertise in cardiology, oncology, orthopedics, men's health, and minimally invasive surgery and is home to the state's first Joint Commission-certified Stroke Center and robotic surgery program. The hospital, which received more than $23 million in external research funding last year, is nationally known for its HIV/AIDS and behavioral and preventive medicine research, including weight control, physical activity and smoking cessation. The Miriam Hospital has been awarded Magnet Recognition for Excellence in Nursing Services four times and is a founding member of the Lifespan health system. Follow us on Facebook (www.facebook.com/miriamhospital) and on Twitter (@MiriamHospital).