(Press-News.org) Scientists have found that the anti-inflammatory molecule, IL-10, may improve success rates of skin autografts (skin moved from one site of the body to another). This information provides a valuable drug target that may benefit burn and accident victims. Specifically, researchers from Portugal and Brazil show that IL-10 plays an important role in whether or not an isogenic skin graft (skin from one individual grafted into another genetically identical) is successful and that the cells responsible for this effect are from the donor skin and not from any tissue of the recipient. This finding appears in the August 2012 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org).
"Much work is needed to advance from mouse experiments to finding in humans," said Luciana Vieira de Moraes, Ph.D., a researcher involved in the work from the Disease Genetics Lab at Instituto Gulbenkian de Ciência in Oeiras, Portugal. "However, monitoring IL-10 levels in the graft tissue may improve therapeutic success."
To make this discovery, scientists conducted experiments using different groups of mice, some of which were genetically modified to not produce IL-10. The first group, which produced IL-10, received a tail skin graft from mice that lacked IL-10. These grafts were not accepted by the recipient. The second group that did not produce IL-10 received tail skin from donors that had IL-10. In this case grafts were accepted. These findings suggest that IL-10 is important immediately after transplantation.
"This study shows that donor skin is not a passive player in the grafting process. Indeed, immune cells in the skin play an active role in whether or not the graft is accepted or rejected by the body. While considerable work remains, these findings open the door to exploit the IL-10 pathway to aid in skin grafting procedures in a variety of clinical settings," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology.
### The Journal of Leukocyte Biology (http://www.jleukbio.org) publishes peer-reviewed manuscripts on original investigations focusing on the cellular and molecular biology of leukocytes and on the origins, the developmental biology, biochemistry and functions of granulocytes, lymphocytes, mononuclear phagocytes and other cells involved in host defense and inflammation. The Journal of Leukocyte Biology is published by the Society for Leukocyte Biology.
Details: Tatiana Takiishi, Carlos Eduardo Tadokoro, Luiz Vicente Rizzo, and Luciana Vieira de Moraes. Early IL-10 production is essential for syngeneic graft acceptance. J Leukoc Biol. August 2012; doi:10.1189/jlb.1111569; http://www.jleukbio.org/content/92/2/259.abstract
IL-10 from donor skin cells helps the body incorporate skin grafts
New research published in the Journal of Leukocyte Biology suggests that keratinocytes are a major source of IL-10 production and that IL-10 is important for successful skin grafting between genetically identical mice
2012-07-31
ELSE PRESS RELEASES FROM THIS DATE:
Men with large waists face an increased risk of frequent urination
2012-07-31
Men with large waists urinate more frequently than their slimmer counterparts, according to research in the August issue of the urology journal BJUI.
Researchers from Weill Medical College, Cornell University, New York, found that men with waists measuring 100cm plus reported up to three times more urinary problems than men with waists of 90cm or less.
They also found that larger waist measurements were associated with a greater prevalence of high blood pressure, cardiovascular disease, type 2 diabetes and erection and ejaculation problems.
"The global epidemic ...
Autoantibodies damage blood vessels in the brain
2012-07-31
The presence of specific autoantibodies of the immune system is associated with blood vessel damage in the brain. These findings were made by Marion Bimmler, a graduate engineer of medical laboratory diagnostics at the Max Delbrück Center for Molecular Medicine Berlin-Buch and Dr. Peter Karczewski of the biotech company E.R.D.E.-AAK-Diagnostik GmbH in studies on a rat model. The researchers' results suggest that autoimmune mechanisms play a significant role in the pathogenesis and progression of Alzheimer's and vascular dementia (PloS ONE, doi:10.1371/journal.pone.0041602)*.
Antibodies ...
Personality and social psychology at the 2012 APA Convention
2012-07-31
From how relationships affect our health to the psychology of an awkward party moment to why we often choose ignorance over information – a guide to some talks with new research in personality and social psychology at the APA Convention in Orlando, Aug. 2-5, 2012 ...
Costs of forgiveness in marriage
It is not always best to forgive and forget in marriage, according to new research that looks at the costs of forgiveness. Sometimes expressing anger might be necessary to resolve a relationship problem – with the short-term discomfort of anger benefiting the health of the ...
Canadians super-sizing Canada's Food Guide servings: York University study
2012-07-31
TORONTO, July 31, 2012 – Think you know what one serving of food looks like? You may want to think again, according to a new study from York University.
Many people overestimate the size of one serving of food as defined in Canada's Food Guide, so they may be overeating even if they believe they are being careful, according to a study by Jennifer Kuk, a professor in the School of Kinesiology & Health Science in York's Faculty of Health, and lead author Sharona Abramovitch, a former graduate student at York. The study was published online today in the journal Applied ...
Protein-based coating could help rehabilitate long-term brain function
2012-07-31
Brain-computer interfaces are at the cutting edge for treatment of neurological and psychological disorder, including Parkinson's, epilepsy, and depression. Among the most promising advance is deep brain stimulation (DBS) — a method in which a silicon chip implanted under the skin ejects high frequency currents that are transferred to the brain through implanted electrodes that transmit and receive the signals. These technologies require a seamless interaction between the brain and the hardware.
But there's a catch. Identified as foreign bodies by the immune system, the ...
Can herbal products provide sun protection?
2012-07-31
New Rochelle, NY, July 31, 2012—Recent research supports the ability of some herbal agents, taken orally or applied topically, to prevent sunburn and limit the damage caused by excessive exposure to ultraviolet (UV) light. Natural products with proven and promising photoprotective properties are highlighted in an article in Alternative and Complementary Therapies, published by Mary Ann Liebert, Inc., publishers. The article is available free on the Alternative and Complementary Therapies website at http://www.liebertpub.com/act.
The article "Herbal Sunscreens and Ultraviolet ...
Computational analysis identifies drugs to treat drug-resistant breast cancer
2012-07-31
HEIDELBERG, 31 July 2012 – Researchers have used computational analysis to identify a new Achilles heel for the treatment of drug-resistant breast cancer. The results, which are published in Molecular Systems Biology, reveal that the disruption of glucose metabolism is an effective therapeutic strategy for the treatment of tumours that have acquired resistance to front-line cancer drugs such as Lapatinib.
"The growth and survival of cancer cells can often be impaired by treatment with drugs that interfere with the actions of one or more oncogenes," said Prahlad Ram, the ...
Economic recession leads to increased entrepreneurship, MU study finds
2012-07-31
COLUMBIA, Mo. — The recent economic recession has caused many changes in the business landscape across the country, including high unemployment rates. Due to these high rates and the struggling economy, University of Missouri researchers have found that in recent years the number of Americans engaging in entrepreneurship has risen significantly. Maria Figueroa-Armijos, a doctoral candidate in the University of Missouri Truman School of Public Affairs, says that this trend could be positive for the future.
"We've seen similar trends occur in past economically slow periods ...
Chemistry on Mars video with Curiosity Rover from the American Chemical Society
2012-07-31
WASHINGTON, July 31, 2012 - After an epic 354-million-mile trek through space, the Mars Curiosity Rover is zooming along at 13,000 miles per hour toward a scheduled August 6 landing on the Red Planet to search for evidence of extraterrestrial life. The newest episode of the American Chemical Society's (ACS') award-winning Bytesize Science video series highlights Curiosity Rover's mission, scientific instrumentation and the role that chemistry plays in the search for life on other planets. The video, produced by the ACS Office of Public Affairs, is available at www.BytesizeScience.com. ...
Adding a '3D print' button to animation software
2012-07-31
Cambridge, Mass. - July 31, 2012 - Watch out, Barbie: omnivorous beasts are assembling in a 3D printer near you.
A group of graphics experts led by computer scientists at Harvard have created an add-on software tool that translates video game characters -- or any other three-dimensional animations -- into fully articulated action figures, with the help of a 3D printer.
The project is described in detail in the Association for Computing Machinery (ACM) Transactions on Graphics and will be presented at the ACM SIGGRAPH conference on August 7.
Besides its obvious consumer ...
LAST 30 PRESS RELEASES:
Survey confirms radiation and orthopedic health hazards in cardiac catheterization laboratories are ‘unacceptable’
Study finds consumer devices can be used to assess brain health
Teachers' negative emotions impact engagement of students, new study finds
Researchers see breakthrough with biofuel
White blood cells use brute force to dislodge bacteria
Foundation AI model predicts postoperative risks from clinical notes
Brain functional networks adapt in response to surgery and Botox for facial palsy
Multimodal AI tool supports ecological applications
New University of Minnesota research shows impact of anxiety and apathy on decision-making
Fred Hutch announces 10 recipients of the 2025 Harold M. Weintraub Graduate Student Award
30 million euros for a novel method of monitoring the world's oceans and coastal regions using telecommunications cables
New multicenter study shows: Which treatment helps best with high-risk acute pulmonary embolism
Hidden dangers and myths: What you need to know about HPV and cancer
SNU researchers develop world’s first technology to observe atomic structural changes of nanoparticles in 3D
SNU researchers develop a new synthesis technology of single crystal 2D semiconductors, “Hypotaxy,” to enhance the commercialization of next-generation 2D semiconductors
Graphene production method offers green alternative to mining
Researchers discover a cause of leptin resistance—and how to reverse it
Heat from the sun affects seismic activity on Earth
Postoperative aspiration pneumonia among adults using GLP-1 receptor agonists
Perceived discrimination in health care settings and care delays in patients with diabetes and hypertension
Postoperative outcomes following preweekend surgery
Nearly 4 of 10 Americans report sports-related mistreatment
School absence patterns could ID children with chronic GI disorders, research suggests
Mount Sinai researchers identify molecular glues that protect insulin-producing cells from damage related to diabetes
Study: Smartwatches could end the next pandemic
Equal distribution of wealth is bad for the climate
Evidence-based strategies improve colonoscopy bowel preparation quality, performance, and patient experience
E. (Sarah) Du, Ph.D., named Senior Member, National Academy of Inventors
Study establishes “ball and chain” mechanism inactivates key mammalian ion channel
Dicamba drift: New use of an old herbicide disrupts pollinators
[Press-News.org] IL-10 from donor skin cells helps the body incorporate skin graftsNew research published in the Journal of Leukocyte Biology suggests that keratinocytes are a major source of IL-10 production and that IL-10 is important for successful skin grafting between genetically identical mice