Sorafenib does not extend overall survival as third or fourth line therapy in lung cancer
Phase III MISSION trial - EGFR status may help select patients who will benefit most
Vienna, Austria, 29 September 2012 – Treatment with the drug sorafenib as a third or fourth line therapy does not result in improved overall survival among patients with advanced non-small cell lung cancer (NSCLC), according to findings released at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna. However, a post-hoc biomarker analysis of the trial data that was also presented suggests that patients with EGFR-mutant tumors may benefit.
Sorafenib is an oral inhibitor of several tyrosine protein kinases, which can be active in cancers. At the meeting, Dr Luis Paz-Ares from from Virgen del Rocio University Hospital in Seville, Spain, reported the findings of the phase III MISSION trial, a randomized, double-blind, placebo-controlled study of monotherapy administration of sorafenib in 703 patients who were randomly assigned to either oral sorafenib 400mg twice daily or placebo.
Median overall survival, the study's primary end-point, was similar in the two groups (248 vs 253 days; HR 0.99, p=0.4687) the researchers found, while median progression-free survival (HR 0.61; p END
Sorafenib is an oral inhibitor of several tyrosine protein kinases, which can be active in cancers. At the meeting, Dr Luis Paz-Ares from from Virgen del Rocio University Hospital in Seville, Spain, reported the findings of the phase III MISSION trial, a randomized, double-blind, placebo-controlled study of monotherapy administration of sorafenib in 703 patients who were randomly assigned to either oral sorafenib 400mg twice daily or placebo.
Median overall survival, the study's primary end-point, was similar in the two groups (248 vs 253 days; HR 0.99, p=0.4687) the researchers found, while median progression-free survival (HR 0.61; p END