(Press-News.org) A variant in a gene involved with inflammation and the immune response is linked with a decreased risk of lung cancer. That is the finding of an analysis published early online in CANCER, a peer-reviewed journal of the American Cancer Society. The results add to the growing body of literature implicating these processes in the development of lung cancer.
Meredith Shiels, PhD, MHS and Anil Chaturvedi, PhD, of the National Cancer Institute in Rockville, MD, and their colleagues analyzed 1,429 variants in inflammation- and immunity-related genes from 378 patients with lung cancer and 450 healthy controls from the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial. The investigators observed a significant link between lung cancer and 81 single nucleotide polymorphisms (SNPs) located in 44 genes. They then compared these results with observed or imputed data from four recently completed genome-wide association studies (GWAS) that included 5,739 lung cancer cases and 5,848 controls. Of the 81 SNPs, one in particular—named rs4648127 and located within the NFKB1 gene—was associated with lung cancer in both analyses. This SNP was linked with an estimated 44 percent reduced risk of lung cancer in the cancer screening trial and a 21 percent reduced risk in the combined GWAS analysis.
The NF-κB, or nuclear factor kappa B, protein that is produced in part from the NFKB1 gene is known to play an important role in immunity and inflammation by regulating gene expression, cell death, and cell proliferation. Also, previous research has shown that immunity and inflammation may affect the development of lung cancer. "Our study provides further evidence that inflammation may be associated with lung cancer risk," said Dr. Shiels. She added that future studies should further examine the NFKB1 gene and its relationship with lung cancer risk.
URL Upon publication: http://doi.wiley.com/10.1002/cncr.27605
### END
Gene variant linked with reduced lung cancer risk
2012-10-08
ELSE PRESS RELEASES FROM THIS DATE:
Patient navigation leads to faster diagnosis for breast cancer, according to new study
2012-10-08
WASHINGTON, D.C. –Today researchers from The George Washington University published a study showing that breast cancer patients can reduce potentially dangerous delays in the identification of breast cancer with the assistance of patient navigation services. Patient navigation—a service that helps patients overcome barriers to getting health care, including setting up appointments, dealing with health insurance, and helping with fears about cancer—led to a nearly four-fold reduction in the time it took to diagnose a suspicious breast lump, the new study found.
"The time ...
Nearly half of children with autism wander or 'bolt' from safe places
2012-10-08
(Baltimore, MD) – A new study published today in the journal Pediatrics (Epub ahead of print) found that nearly half of children with autism spectrum disorders (ASD) are reported to wander or "bolt," and more than half of these children go missing. Led by researchers from the Interactive Autism Network (IAN), the nation's largest online autism research initiative and a project of the Kennedy Krieger Institute, this study provides the most comprehensive estimate of elopement occurrence in a United States community-based sample of more than 1,200 children with ASD.
"Since ...
Super-microbes engineered to solve world environmental problems
2012-10-08
Environmental problems, such as depleting natural resources, highlight the need to establish a renewable chemical industry. Metabolic engineering enhances the production of chemicals made by microbes in so-called "cell factories". Next Monday, world class scientist Professor Sang Yup Lee of KAIST (Korea Advanced Institute of Science and Technology) will explain how metabolic engineering could lead to the development of solutions to these environmental problems.
For example, the polyester polylactic acid (PLA) is a biodegradable material with a wide range of uses, from ...
Put an End to Bullying!
2012-10-08
NAAFA is proud of Jennifer Livingston, a TV news anchor from Wisconsin, who took a public on-air stand against a bully who felt it appropriate to call her out as a "bad example" and not a "suitable" role model for youth, particularly girls, because of her body size. Bullying comes in many forms and is pervasive in our society today. Fat people are among the most bullied. People come in all sizes. Good role models are not determined by body size. Good role models come in all sizes, races and creeds.
We need more people of size to stand up to say that ...
Content Marketing Expert Michelle Salater to Host Webinar on Writing Website Copy That Converts
2012-10-08
According to a recent study from Forrester Research, Inc., 167 million U.S. consumers purchase goods and services online. That staggering number is projected to climb to 192 million in 2016. Because these consumers are making purchasing decisions based on online content, Michelle Salater has announced 7 Website Copy Tips Guaranteed to Convert Prospects to Clients—the Power of Your Website Message and Why You Should Care.
This hour-long webinar is intended for entrepreneurs who want website copy that speaks to their target market, but are unsure how to create an effective, ...
Improve Your Communication and Public Speaking in Just 60 Seconds with Impromptu Guru's New Tip-Filled Videos
2012-10-08
"Gaining confidence in one's communication and speaking ability is important," says Jill Schiefelbein, founder of Impromptu Guru and the creator of the videos. "I wanted to create a product where people could get actionable advice on common communication and public speaking issues in an easy-to-access format. The 60 Second Guru series meets these goals."
Strong communication and public speaking abilities are among the tops skills requested by employers. However, many people don't take the time necessary to develop or improve these skills.
To help ...
Ending the Homework Battle! Free Live Webinar
2012-10-08
Homework time is perhaps the most important opportunity for your child to learn and exercise what he or she has learned at school. Without this opportunity, your child has little chance of succeeding at school. That is why it is vitally important to make sure your child is able to adequately and accurately complete his or her homework on a daily basis. For your child to succeed, he or she must have the skills and tools necessary to make homework time a success. This webinar explores:
1. Quick and easy methods and strategies to help your child complete his or her homework ...
"50 Shades of Kale" Free on Amazon Today
2012-10-08
50 SHADES OF KALE by Dr. Drew Ramsey and veteran cookbook author Jennifer Iserloh pleases with 50 recipes that promise to trim your waistline, build your brain, and boost your sex drive.
This 93-page cookbook is chock-full of meal plans and tips for optimal kale care and preparation, and compellingly makes the case for why you need to include kale in your culinary repertoire now. Whether you are vegan, gluten-free, or a knife carrying meat eater, Dr. Ramsey and Iserloh will turn you on to kale.
From breakfast to cocktails, and Kaleonnaise to Thai'd Up Roughage, you'll ...
VoiceNation Supports World Day of Bullying Prevention
2012-10-08
On October 1st, which kicked off National Bullying Prevention Awareness Month, the staff of VoiceNation, the industry leader in live answering and virtual receptionist services, donned blue shirts in support of STOMP Out Bullying (the signature program of Love Our Children USA ) and its initiative Blue Shirt Day World Day of Bullying Prevention.
VoiceNation is helping Love Our Children USA , a national non-profit organization working to prevent and fight all forms of violence and neglect against children, spread the word and campaign to STOMP Out Bullying .
According ...
Red Box Lingerie Promotes Breast Cancer Awareness
2012-10-08
Red Box Lingerie is offering customers online the opportunity to give a little and still get money off, in aid of promoting and supporting Breast Cancer Awareness this month.
Throughout October 2012 Red Box Lingerie will be offering their customers the opportunity to own a stunning collection by the British Designer Fleur of England. The Fleur of England Berry Kiss collection can be purchased with a 10% discount plus 10% of what Red Box Lingerie make from each sale, will go to the Breast Cancer Campaign, for more information visit http://www.breastcancercampaign.org/.
"We ...