Glowing DNA invention points towards high speed disease detection

ROCHESTER, Minn. -- Mayo Clinic researchers have identified a new therapy for patients with neuromyelitis optica that appears to stop inflammation of the eye nerves and spinal cord. NMO is a debilitating central nervous system disorder that is often misdiagnosed as multiple sclerosis (MS). In the study, patients with severe symptoms of the disease, also known as NMO, were given eculizumab, a drug typically used to treat blood disorders. While not a cure, the therapy Mayo Clinic researchers used in the study to halt attacks could potentially lead to longer attack-free ...

Scientists at the National Physical Laboratory (NPL) and the University of Leicester have been commissioned by the European Space Agency (ESA) to investigate the feasibility of using dead stars to navigate spacecraft in deep space. The findings of the research will advise ESA strategy and if feasible this technique may in future revolutionise the way spacecraft navigate in the outer Solar System and beyond. Spacecraft navigation currently relies on radio transmissions between a distant craft and a network of ground-stations on Earth. This means that the craft has to ...

This press release is available in German. The iron-sulfur protein IspH plays a central role in the terpene metabolism of several pathogens. The mechanism of the reaction provides an approach for developing new antibiotics, particularly against malaria and tuberculosis. While researching this enzyme, biochemists at the Technische Universitat Munchen discovered a previously unknown reaction: IspH accepts two completely different classes of molecules as partners. This surprising insight, published in Nature Communications, opens up new perspectives in combating infectious ...

Scientists at the Montreal Neurological Institute and Hospital – The Neuro, McGill University working with a team at Oxford University have uncovered the genetic defect underlying a group of rare genetic disorders. Using a new technique that has revolutionized genetic studies, the teams determined that mutations in the RMND1 gene were responsible for severe neurodegenerative disorders, in two infants, ultimately leading to their early death. Although the teams' investigations dealt with an infant, their discovery also has implications for understanding the causes of ...

Tampa, FL (Oct. 8, 2012) -- The chaperone protein Grp94 can interfere with the clearance of another protein known to cause the glaucoma when mutated, a new study led by researchers at the University of South Florida has found. Using a cell model, the researchers also demonstrated that a new specific inhibitor of Grp94 facilitates clearance of the genetically-defective protein, called myocilin, from cells. Reported online this month in JBC (The Journal of Biological Chemistry), the discoveries could lead to a new treatment for some hereditary cases of glaucoma, an eye ...

If quantum computers are ever going to perform all those expected feats of code-breaking and number crunching, then their component qubits---tiny ephemeral quantum cells held in a superposition of internal states---will have to be protected from intervention by the outside world. In other words, decoherence, the loss of the qubits' quantum integrity, has to be postponed. Now theoretical physicists at the Joint Quantum Institute (JQI) and the University of Maryland have done an important step forward to understand qubits in a real-world setup. In a new study they show, ...

Biofuels are going to save us from climate threats and the oil crisis, while at the same time providing an opportunity to the smallholder farmers of the world. Hopes are high, but completely unrealistic. It is like trying to push a square peg into a round hole, according to a current thesis at Linköping University. Bioenergy could replace fossil fuels and solve the looming energy crisis. Into the bargain, we will benefit from reduced greenhouse gas emissions. A further bonus could be that demand for biofuels gives a lift to smallholder farmers in poor countries, who would ...

A newly discovered function of PARP-1 could be the key to more effective therapeutics to treat advanced prostate cancer patients, a recent preclinical study published in Cancer Discovery by Jefferson's Kimmel Cancer Center researchers suggests. The team, led by Karen E. Knudsen, Ph.D., Professor in the Departments of Cancer Biology, Urology, & Radiation Oncology at Thomas Jefferson University, found that functions of PARP-1 not only include DNA damage repair but also androgen receptor (AR) regulation in advanced prostate cancer growth and progression. PARP inhibition ...

Irvine, Calif., Oct. 9, 2012 – Chronic kidney disease changes the composition of intestinal bacterial microbes that normally play a crucial role in staving off disease-causing pathogens and maintaining micronutrient balance, according to UC Irvine researchers. This profound alteration of the gut microbial population may contribute to the production of uremic toxins, systemic and local inflammation, and nutritional abnormalities present in patients with advanced renal disease, they said. Study leader Dr. N.D. Vaziri of the UCI School of Medicine's Division of Nephrology ...

CAMBRIDGE, Mass. -- Carbon nanotubes offer a powerful new way to detect harmful gases in the environment. However, the methods typically used to build carbon nanotube sensors are hazardous and not suited for large-scale production. A new fabrication method created by MIT chemists — as simple as drawing a line on a sheet of paper — may overcome that obstacle. MIT postdoc Katherine Mirica has designed a new type of pencil lead in which graphite is replaced with a compressed powder of carbon nanotubes. The lead, which can be used with a regular mechanical pencil, can inscribe ...