Study confirms benefits of transcatheter aortic valve replacement over 3 years

Results of PARTNER Cohort B trial presented at TCT 2012

2012-10-25

(Press-News.org) MIAMI, FL – OCTOBER 24, 2012 – A study found that transcatheter aortic valve replacement (TAVR) yielded lower mortality rates after three years compared with medical therapy in patients deemed to be ineligible for conventional aortic valve surgery. Results of the PARTNER Cohort B trial were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine.

TAVR is the recommended treatment for patients with severe aortic stenosis who are not suitable candidates for surgery. Outcomes beyond two years in such patients have not yet been extensively studied.

Inoperable patients with severe symptomatic aortic stenosis (AS) were randomly assigned to transfemoral TAVR or to standard therapy (which often included balloon aortic valvuloplasty) in the PARTNER trial. Data on three-year outcomes were analyzed according to intention to treat (ITT).

A total of 358 patients underwent randomization at 21 centers. The Kaplan Meier estimated rates of death at three years were 54.1 percent in the TAVR group and 80.9 percent in the standard-therapy group (P END

ELSE PRESS RELEASES FROM THIS DATE:

Results of the ISAR-LEFT MAIN 2 trial presented at TCT 2012

2012-10-25

MIAMI, FL – OCTOBER 24, 2012 – A study found that second-generation drug-eluting stents are safe and effective in the treatment of left main coronary artery lesions. Results of the ISAR-LEFT MAIN 2 trial were presented at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. Patients undergoing invasive treatment of unprotected left main coronary artery (uLMCA) lesions are often ...

Scientists target bacterial transfer of resistance genes

2012-10-25

CHAMPAIGN, Ill. — The bacterium Streptococcus pneumoniae – which can cause pneumonia, meningitis, bacteremia and sepsis – likes to share its antibiotic-defeating weaponry with its neighbors. Individual cells can pass resistance genes to one another through a process called horizontal gene transfer, or by "transformation," the uptake of DNA from the environment. Now researchers report that they can interrupt the cascade of cellular events that allows S. pneumoniae to swap or suck up DNA. The new findings, reported in the journal PLoS ONE, advance the effort to develop ...

Research findings breathe new life into lung disease

2012-10-25

TORONTO, Oct. 24, 2012--It turns out the muscle cells on the outside of blood vessels have been wrongly accused for instigating lung disease. New research shows that while these muscle cells are responsible for constricting or dilating the blood vessels, they are not responsible for sensing the amount of oxygen that gets to the lungs. That message comes from the endothelial cells – special cells that line the blood vessels – along a "signalling pathway." When a person is low on oxygen, blood vessels throughout the body expand to improve the delivery of this vital molecule ...

Is obesity irreversible? Timing is key in weight loss, U-M research shows

2012-10-25

ANN ARBOR, Mich. — Joint research between the University of Michigan and the Argentina-based National Council of Science and Technology (CONICET) has shed light on one of the most frustrating mysteries of weight loss – why the weight inevitably comes back. A novel animal model showed that the longer mice remained overweight, the more "irreversible" obesity became, according to the new study that appeared online ahead of print Oct.24 in the Journal of Clinical Investigation. Over time, the static, obese state of the mice reset the "normal," body weight set point to ...

Mesh-covered stent helps restoration of blood flow in heart attack patients undergoing PCI

2012-10-25

MIAMI, FL – OCTOBER 24, 2012 – A clinical trial found that the use of a next generation, micronet, mesh-covered stent demonstrated improved restoration of blood flow to heart tissue, compared to the use of either bare-metal or drug-eluting stents in heart attack patients undergoing angioplasty. Results of the MASTER trial were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium and will appear in the November 6th issue of the Journal of the American College of Cardiology. Sponsored by the Cardiovascular Research Foundation, ...

Knee replacement not an 'easy solution' for obese patients

2012-10-25

ROSEMONT, IL–Obese patients have a greater risk of complications following total knee replacement surgery, including post-surgical infections, according to a new literature review recently published in the Journal of Bone and Joint Surgery (JBJS). Because of complications, obese patients are more likely to require follow-up surgery (revision). Obesity is reaching epidemic proportions, particularly in the United States, and is a well-documented risk factor for the development of osteoarthritis. Arthritis is initially treated nonsurgically, but total joint replacement often ...

Ghost busting

2012-10-25

The fourth installment of the Paranormal Activity films topped the box office last week. Television channel SyFy's hit show Ghost Hunters scares up big ratings, and has spawned copycat series on networks ranging from Biography to Animal Planet. The omnipresence of paranormal entertainment piqued the interest of Paul Brewer, professor of communication, who wondered what makes viewers believe—or disbelieve— what they see on the screen. His resulting study, recently published in the journal Science Communication, examines the influence of media messages about paranormal ...

Measuring Table-Top Accelerators’ State-of-the-Art Beams

2012-10-25

Part Two: Slicing through the electron beam Wim Leemans of Berkeley Lab's Accelerator and Fusion Research Division heads LOASIS, the Laser and Optical Accelerator Systems Integrated Studies, an oasis indeed for students pursuing graduate studies in laser plasma acceleration (LPA). Among the most promising applications of future table-top accelerators are new kinds of light sources, in which their electron beams power free electron lasers. "If our LPA electron bunches had good enough quality for free electron lasers – and were really only femtoseconds long – we should ...

NASA sees Tropical Storm Sandy approaching Jamaica

2012-10-25

NASA satellites are closely monitoring Tropical Storm Sandy in visible and infrared light as it approaches Jamaica. Sandy is now responsible for hurricane and tropical storm warnings and watches from Jamaica to Cuba, the Bahamas and southern Florida. Sandy is expected to become a hurricane before it reaches Jamaica and Cuba. On Oct. 23, 2012 at 1545 UTC (11:45 a.m. EDT), the Moderate Resolution Imaging Spectroradiometer (MODIS) instrument captured a visible image of Tropical Storm Sandy when its center was a couple of hundred miles south of Jamaica. Sandy's clouds filled ...

Challenging Parkinson's dogma

2012-10-25

Scientists may have discovered why the standard treatment for Parkinson's disease is often effective for only a limited period of time. Their research could lead to a better understanding of many brain disorders, from drug addiction to depression, that share certain signaling molecules involved in modulating brain activity. A team led by Bernardo Sabatini, Takeda Professor of Neurobiology at Harvard Medical School, used mouse models to study dopamine neurons in the striatum, a region of the brain involved in both movement and learning. In people, these neurons release ...

University of Maryland School of Medicine launches groundbreaking study on THC/CBD therapy for dementia-related agitation at end of life

Targeting stem-property and vasculogenic mimicry for sensitizing paclitaxel therapy of triple-negative breast cancer by biomimetic codelivery

SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts

Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis

An anti-complement homogeneous polysaccharide from Houttuynia cordata ameliorates acute pneumonia with H1N1 and MRSA coinfection through rectifying Treg/Th17 imbalance in the gut–lung axis and NLRP3 i

ALKBH3-regulated m1A of ALDOA potentiates glycolysis and doxorubicin resistance of triple negative breast cancer cells

A photodynamic nanohybrid system reverses hypoxia and augment anti-primary and metastatic tumor efficacy of immunotherapy

[Press-News.org] Study confirms benefits of transcatheter aortic valve replacement over 3 years
Results of PARTNER Cohort B trial presented at TCT 2012

Study confirms benefits of transcatheter aortic valve replacement over 3 years

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: