Mesh-covered stent helps restoration of blood flow in heart attack patients undergoing PCI

Results of the MASTER trial reported at TCT 2012 and published in JACC

2012-10-25

(Press-News.org) MIAMI, FL – OCTOBER 24, 2012 – A clinical trial found that the use of a next generation, micronet, mesh-covered stent demonstrated improved restoration of blood flow to heart tissue, compared to the use of either bare-metal or drug-eluting stents in heart attack patients undergoing angioplasty. Results of the MASTER trial were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium and will appear in the November 6th issue of the Journal of the American College of Cardiology. Sponsored by the Cardiovascular Research Foundation, TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine.

The lack of sufficient restoration of blood flow after an angioplasty (percutaneous coronary intervention) in heart attack patients is a common issue, and can result in increased size of the affected heart tissue, as well as death. The MASTER trial tested a new stent, the MGuard stent that uses a stent covered in a micronet mesh that is designed to prevent or reduce downstream embolization by holding plaque or thrombus in place against the wall of the blocked artery.

Between July 22, 2011 and May 29, 2012, 433 heart attack patients were enrolled and randomized at 50 sites in nine countries. The median age was 59; 24 percent were female. 217 patients received the new stent and 216 patients receiving either a drug-eluting stent (DES) or bare-metal stent (BMS) were in the control group.

The primary endpoint was the rate of complete (≥70 percent) ST-segment resolution (STR) at 60-90 minutes following the procedure. In the group of patients with the mesh-covered stent, the rate of compete ST-segment resolution was 57.8 percent; in the control group, the rate was 44.7 percent.

"Among heart attack patients undergoing primary percutaneous coronary intervention, the micronet, mesh-covered stent compared to conventional bare-metal and drug-eluting stents resulted in superior rates of epicardial coronary flow and complete ST-segment resolution," said study chairman, Gregg W. Stone, MD. Dr Stone is Professor of Medicine at Columbia University College of Physicians and Surgeons and Director of Cardiovascular Research and Education at the Center for Interventional Vascular Therapy at NewYork-Presbyterian Hospital/Columbia University Medical Center.

"A larger randomized trial is warranted to verify these findings, and determine whether these benefits result in reduced infarct size and/or improved clinical outcomes," said Dr. Stone.

###The results of the MASTER trial will be presented on Wednesday, October 24 at 11:39 AM EST in the Main Arena (Hall D) of the Miami Beach Convention Center.

The MASTER trial was funded by InspireMD. Dr. Stone reported consulting fees from Abbott Vascular, Atrium, Boston Scientific, InspireMD and Medtronic.

About CRF The Cardiovascular Research Foundation (CRF) is an independent, academically focused nonprofit organization dedicated to improving the survival and quality of life for people with cardiovascular disease through research and education. Since its inception in 1991, CRF has played a major role in realizing dramatic improvements in the lives of countless numbers of patients by establishing the safe use of new technologies and therapies in interventional cardiovascular medicine.

Transcatheter Cardiovascular Therapeutics (TCT) is the annual scientific symposium of the Cardiovascular Research Foundation. TCT gathers leading medical researchers and clinicians from around the world to present and discuss the latest developments in the field.

For more information, visit www.crf.org.

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Mesh-covered stent helps restoration of blood flow in heart attack patients undergoing PCI

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