Acid reflux, functional dyspepsia have significant impact on disordered sleep
Baclofen, esomeprazole investigated as treatments
2010-10-19
(Press-News.org) San Antonio, Texas (October 18, 2010) – The impact of upper GI conditions, like gastroesophageal reflux disease (GERD) and functional dyspepsia, on sleep—and treatments aimed at providing relief to heartburn/acid reflux patients who suffer from disordered sleep—were explored in three new studies related to sleep dysfunction presented today at the American College of Gastroenterology's (ACG) 75th Annual Scientific meeting in San Antonio, Texas.
Functional dyspepsia is a common, but poorly understood, upper GI condition affecting approximately 10 percent of U.S. adults. The condition is described as chronic abdominal pain and a sensation of fullness, pressure or discomfort in the upper abdomen. This sensation is associated with eating as symptoms usually worsen after meals.
While the prevalence of disordered sleep in patients with functional dyspepsia is unknown, a new study unveiled today found that disordered sleep is significantly more common in functional dyspepsia patients than in healthy controls.
Patients with functional dyspepsia were 3.25 times more likely to have disordered sleep compared to healthy controls, according to the study, "Functional Dyspepsia: A Risk Factor for Disordered Sleep," which also found that women with functional dyspepsia were 2.3 times more likely to have disordered sleep than men with this same condition. While gender tended to be associated with disordered sleep, age, tobacco and alcohol use was not a factor. The study also found that mental and physical factors were related to disordered sleep in patients with functional dyspepsia.
Routine exercise, for instance, appeared to decrease the likelihood of a patient suffering from sleep disorders. Functional dyspepsia patients also had higher scores for anxiety and depression, according to the study, suggesting that depression may be a contributing factor to functional dyspepsia symptom generation.
"Fatigue changes the sensation for pain, said Brian Lacy, M.D., Ph.D., associate professor of medicine, Dartmouth Medical School who presented the results of the study. "The key finding here is that disordered sleep may affect nerve function in upper GI tract which could lead to worsening dyspepsia, creating a vicious cycle leading to more pain and more insomnia," said Dr. Lacy. He added that, "future clinical trials for functional dyspepsia should include validated measures of sleep, as improvements in functional dyspepsia symptoms may be mirrored by improvements in sleep."
Esomeprazole Reverses Driving Impairment in GERD Induced Sleep Disorders
GERD‐induced sleep dysfunction has a previously unrecognized and significantly adverse affect on simulated driving performance, which improved with esomeprazole, according to the results of another study, "GERD‐Induced Sleep Disorders and a Reversible Driving Impairment with Esomeprazole‐A Prospective Pilot Study."
Dr. David A. Johnson, Chief of Gastroenterology and Professor of Medicine at Eastern Virginia Medical School in Norfolk, Va., presented the findings from this prospective‐pilot study that evaluated 11 healthy patients with well‐established GERD with nocturnal symptoms.
Testing was done in a validated commercial driving simulator that responds to driver inputs (steering, throttle, brake) and generates realistic roadway images. Driving performance (standard deviation of lane variation SDLP) was compared across six consecutive 10‐minute driving periods while subjects were on and off the drug.
According to the study, SDLP increased over time (p=0.0002) and improved with esomeprazole. Patients on esomeprazole had an overall average 62.5 percent decrease in the number of sleep disordered nights vs. a 9.5 percent decrease without the drug. The Epworth Sleepiness Scale, used to determine the level of daytime sleepiness, decreased to 5.9 and 3.5 from 7.9 and 2.5 and GERD symptom score decreased from 2.10 to 0.33.
"The improved ESS score suggests that reduced sleepiness contributed to improved performance," said Dr. Johnson. "We know that GERD impairs sleep quality and next day function as measured by quality of life and work productivity assessments. Furthermore, sleep dysfunction (such as sleep apnea) has been linked to impaired psychomotor function including worsening driving simulator performance.
Therefore, appropriate treatment for patients with GERD and nocturnal symptoms may have potentially new and life‐saving implications."
Dr. Johnson also noted that further prospective blinded controlled trials are warranted to validate these findings.
Baclofen Decreases Reflux, Improving Sleep Quality for Nighttime Heartburn Sufferers
Nighttime heartburn sufferers also may get relief —and better sleep quality, from the muscle‐relaxant and antispastic drug, baclofen, according to results of another new study unveiled today, "Baclofen Decreases Reflux and Improves Sleep Quality in Individuals with Nighttime Heartburn."
While baclofen has been shown to reduce episodes of GERD, this new study found that in addition to reducing the number of reflux events during sleep, baclofen significantly improved several measures of sleep in patients with documented GERD and sleep disturbances.
"About 70 percent of individuals who have GERD also suffer from nighttime heartburn, and 40 percent of those people say they experience disturbed sleep at night," said study co‐author Dr. William Orr, president and CEO of the Lynn Health Science Institute and a clinical professor of medicine at the University of Oklahoma Health Sciences Center. "They don't feel good the next day and they don't perform as well."
Approved by the FDA in 1977, bacolfen is typically used by neurologists to treat uncontrolled movements, such as shakes and tremors. The drug inhibits nerve activity within the part of the brain that controls the contraction and relaxation of skeletal muscles.
"In this study, we found that bacolfen significantly reduces the amount of waking which occurs after the onset of sleep," said Dr. Orr. "Baclofen addresses the physiological causes of reflux, by preventing the relaxation of the lower esophageal sphincter and preventing the stomach acid from entering the esophagus. Few drugs inhibit the occurrence of reflux and 40 to 50 percent of those taking PPIs don't get satisfactory relief, especially at nighttime,"
Baclofen reduced the number of reflux events compared to a placebo (4 events vs. 1.3). Patients on baclofen also had more sleep time (434 minutes vs. 379 minutes) and greater sleep efficiency (91 percent vs. 79 percent), according to the study. "The results of this study suggest that baclofen could be a useful adjunct therapy to proton pump inhibitors in patients with nighttime heartburn and sleep disturbance," said Dr. Orr.
INFORMATION:
About the American College of Gastroenterology
Founded in 1932, the American College of Gastroenterology (ACG) is an organization with an international membership of more than 11,000 individuals from 80 countries. The College is committed to serving the clinically oriented digestive disease specialist through its emphasis on scholarly practice, teaching and research. The mission of the College is to serve the evolving needs of physicians in the delivery of high quality, scientifically sound, humanistic, ethical, and cost‐effective health care to gastroenterology patients. www.acg.gi.org View releases on other research breaking at the ACG meeting at www.acg.gi.org/media/press.asp
ELSE PRESS RELEASES FROM THIS DATE:
Notable racial disparities in diagnosis, treatment and outcomes of colorectal cancer
2010-10-19
San Antonio, Texas (October 18, 2010) – The latest colorectal cancer research presented at the American College of Gastroenterology's (ACG) 75th Annual Scientific meeting in San Antonio this week strengthens the growing body of evidence that suggests significant disparity in colorectal cancer (CRC) demographics and outcomes between various races.
In the first in a series of studies investigating colorectal cancer disparities that exist between various races, researchers conducted a retrospective analysis of colonoscopies performed in young patients from July 2003 to December ...
Encouraging findings suggest new avenues for treating liver disease in overweight Americans
2010-10-19
San Antonio, Texas, October 18, 2010 – Estimates of the prevalence of liver disease suggest that one‐third of the United States population has non‐alcoholic fatty liver disease (NAFLD). NAFLD is now the most common cause for elevated liver function tests in the United States, a trend related to the obesity epidemic in this country. Non‐alcoholic steatohepatitis (NASH), the progressive form of NAFLD, can lead to cirrhosis and all its complications. Two studies presented at the 75th Annual Scientific Meeting of the American College of Gastroenterology investigated ...
New studies highlight obesity's impact on gastrointestinal health
2010-10-19
San Antonio, Texas (October 18, 2010) – The association between obesity and gastrointestinal-related cancers and coronary artery disease; the link between an overweight or obese body mass index and the severity of Crohn's disease; and whether inflammatory bowel disease is an independent risk factor for coronary artery disease, were among the highlights of new research that was presented this week at the American College of Gastroenterology's (ACG) 75th Annual Scientific meeting in San Antonio.
Obesity Linked to Increased Liver Cancer Risk, Adenoma Recurrence
Although ...
Investment in CRC screening targeting pre-medicare population could cut medicare treatment costs
2010-10-19
San Antonio, Texas (October 18, 2010) – Investment in screening programs that target the pre-Medicare population, individuals aged between 50 and 64, is needed to reduce the costs of colorectal cancer in the Medicare program, according to the results of a new study, "Cost-Savings to Medicare from Increased Colorectal Cancer Screening in the Pre-Medicare Population," unveiled today at the American College of Gastroenterology's (ACG) 75th Annual Scientific meeting in San Antonio, Texas.
"With rising chemotherapy costs and aging of the population, the Medicare program will ...
National Stroke Association survey reveals more than half of stroke survivors suffer added burden of little known neurologic condition
2010-10-19
CENTENNIAL, CO – October 18, 2010 – A survey released today by National Stroke Association shows that 53 percent of stroke survivor respondents suffer from symptoms of another neurologic condition called pseudobulbar affect (PBA), a condition thought to be caused by structural damage in the brain due to injury or disease. PBA causes involuntary and unpredictable outbursts of laughing or crying, often in socially inappropriate situations. Even though a significant proportion of stroke survivors suffer from PBA, fewer than one in five are familiar with the condition.
Survey ...
Colonoscopy technique increases polyp detection in far reaches of right colon
2010-10-19
San Antonio, Texas, October 18, 2010 – Research exploring the progression of colon polyps to colorectal cancer and evaluating techniques to improve polyp detection was among the clinical science presented at the 75th Annual Scientific Meeting of the American College of Gastroenterology in San Antonio today.
The Progression to Colorectal Cancer in Flat Polyps
Precancerous growths in the colon known as sessile serrated adenomas (SSA) are found in approximately 1 percent of colonoscopy exams. A sessile serrated ademona is a premalignant flat lesion in the colon thought ...
100-million-year-old mistake provides snapshot of evolution
2010-10-19
Research by University of Leeds plant scientists has uncovered a snapshot of evolution in progress, by tracing how a gene mutation over 100 million years ago led flowers to make male and female parts in different ways.
The findings – published this week in the Proceedings of the National Academy of Sciences (PNAS) Online Early Edition – provide a perfect example of how diversity stems from such genetic 'mistakes'. The research also opens the door to further investigation into how plants make flowers – the origins of the seeds and fruits that we eat.
In a number of plants, ...
When vertebrae cross dress: How sloths got their long neck
2010-10-19
By examining the development of bones in the vertebral column, limbs, and ribcage, scientists at the University of Cambridge have discovered how sloths evolved their unique neck skeleton.
From mice to giraffes, mammals are remarkable in that all but a handful of their 5000 species have exactly seven vertebrae in the neck. Among the few that deviate from this number are three-toed sloths, which may have up to ten ribless vertebrae in the neck.
Traditionally, vertebrae above the shoulders that lack ribs are known as cervical or neck vertebrae. Animals such as birds and ...
Removing 2mm around breast cancer tumors prevents residual disease in 98 percent of patients
2010-10-19
Removing an extra two millimetres around an area of invasive breast cancer is sufficient to minimise any residual disease in 98 per cent of patients, according to research published in the November issue of IJCP, the International Journal of Clinical Practice.
Surgeons from the Department of Breast Surgery at Good Hope Hospital, Sutton Coldfield, UK, studied 303 women who had undergone breast conserving surgery at the hospital between 2002 and 2008.
"Breast conserving surgery followed by radiotherapy is a well-established alternative to breast removal and studies have ...
Drivel on Facebook more valuable than we think
2010-10-19
Superficial contacts on Facebook, apparently unnecessary comments, and banal status updates may be more worthwhile than we think. This is shown in a new report from the National IT User Center. The report also predicts the new social media will ultimately lead to more individual entrepreneurs.
Many people are critical of those who collect hundreds of so-called friends on Facebook. Often the majority of these "friends" are old classmates, acquaintances of acquaintances, and the like, relationships that are fundamentally weak. The comments and updates of relatively banal ...
LAST 30 PRESS RELEASES:
Researchers show complex relationship between Arctic warming and Arctic dust
Brain test shows that crabs process pain
Social fish with low status are so stressed out it impacts their brains
Predicting the weather: New meteorology estimation method aids building efficiency
Inside the ‘swat team’ – how insects react to virtual reality gaming
Oil spill still contaminating sensitive Mauritius mangroves three years on
Unmasking the voices of experience in healthcare studies
Pandemic raised food, housing insecurity in Oregon despite surge in spending
OU College of Medicine professor earns prestigious pancreatology award
Sub-Saharan Africa leads global HIV decline: Progress made but UNAIDS 2030 goals hang in balance, new IHME study finds
Popular diabetes and obesity drugs also protect kidneys, study shows
Stevens INI receives funding to expand research on the neural underpinnings of bipolar disorder
Protecting nature can safeguard cities from floods
NCSA receives honors in 2024 HPCwire Readers’ and Editors’ Choice Awards
Warning: Don’t miss Thanksgiving dinner, it’s more meaningful than you think
Expanding HPV vaccination to all adults aged 27-45 years unlikely to be cost-effective or efficient for HPV-related cancer prevention
Trauma care and mental health interventions training help family physicians prepare for times of war
Adapted nominal group technique effectively builds consensus on health care priorities for older adults
Single-visit first-trimester care with point-of-care ultrasound cuts emergency visits by 81% for non-miscarrying patients
Study reveals impact of trauma on health care professionals in Israel following 2023 terror attack
Primary care settings face barriers to screening for early detection of cognitive impairment
November/December Annals of Family Medicine Tip Sheet
Antibiotics initiated for suspected community-acquired pneumonia even when chest radiography results are negative
COVID-19 stay-at-home order increased reporting of food, housing, and other health-related social needs in Oregon
UW-led research links wildfire smoke exposure with increased dementia risk
Most U.S. adults surveyed trust store-bought turkey is free of contaminants, despite research finding fecal bacteria in ground turkey
New therapy from UI Health offers FDA-approved treatment option for brittle type 1 diabetes
Alzheimer's: A new strategy to prevent neurodegeneration
A clue to what lies beneath the bland surfaces of Uranus and Neptune
Researchers uncover what makes large numbers of “squishy” grains start flowing
[Press-News.org] Acid reflux, functional dyspepsia have significant impact on disordered sleepBaclofen, esomeprazole investigated as treatments